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ClinicalTrials.gov public records Last synced Oct 28, 2026, 11:30 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 352 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Functional Colonic Diseases Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Study to Evaluate the Efficacy of Poppi Apple Cider Vinegar Prebiotic Soda to Improve Gut Health In Participants

NCT05418439
View directory record Official record
Conditions
IBS - Irritable Bowel Syndrome
Interventions
Drink Poppi Soda
Dietary Supplement
Lead sponsor
Drink Poppi
Industry
Eligibility
18 Years to 45 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 28, 2026, 11:30 AM EDT
Active, not recruiting Phase 3 Interventional

Neostigmine and Glycopyrrolate by Iontophoresis

NCT06351995
View directory record Official record
Conditions
Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
Interventions
Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
Drug · Device
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Phase 3 Interventional

Study In Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy

NCT00067457
View directory record Official record
Conditions
Irritable Colon, Irritable Bowel Syndrome (IBS)
Interventions
alosetron
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older · Female only
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
190
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 166 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Oct 28, 2026, 11:30 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Ileocecal Sphincter Reflex by Cecal Distension During Colonoscopy

NCT01413945
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
20 Years to 80 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2019 · Synced Oct 28, 2026, 11:30 AM EDT
Not listed Phase 2Phase 3 Interventional

A Study of the Safety and Effectiveness of DDP733 in Treating IBS With Constipation in Females

NCT00547469
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
DDP733
Drug
Lead sponsor
Dynogen Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
62
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 53 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2008 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional Results available

Percutaneous Electrical Nerve Field Stimulation for Adults With Irritable Bowel Syndrome

NCT04428619
View directory record Official record
Conditions
Irritable Bowel Syndrome, Abdominal Pain, Autonomic Nervous System Imbalance
Interventions
Peripheral Electrical Nerve Field Stimulation (PENFS) Device, Sham Device
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 28, 2026, 11:30 AM EDT
Recruiting Phase 2 Interventional

Fecal Microbiota Transplantation for IBS

NCT05776914
View directory record Official record
Conditions
Irritable Bowel Syndrome, Diarrhea
Interventions
Donor Fecal Microbiota Transplantation, Autologous Fecal Microbiota Transplantation
Biological
Lead sponsor
Madhusudan (Madhu) Grover, MBBS
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 28, 2026, 11:30 AM EDT
Recruiting Not applicable Interventional

A Prospective Trial of a Variable Compression System for Moderate to Severe Irritable Bowel Syndrome

NCT07540312
View directory record Official record
Conditions
IBS (Irritable Bowel Syndrome)
Interventions
Variable Compression System
Device
Lead sponsor
PGP Health
Industry
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Kissimmee, Florida • Bolingbrook, Illinois • Southhaven, Mississippi
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 28, 2026, 11:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characterizing Protein Biomarkers of Post-infection Irritable Bowel Syndrome

NCT06032117
View directory record Official record
Conditions
Post-infectious Irritable Bowel Syndrome, Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years to 100 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 28, 2026, 11:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

BÜHLMANN fCAL™ ELISA - Aid in Differentiation of IBD From IBS

NCT02351635
View directory record Official record
Conditions
Inflammatory Bowel Disease, Irritable Bowel Syndrome
Interventions
fecal calprotectin level
Other
Lead sponsor
Bühlmann Laboratories AG
Industry
Eligibility
22 Years and older
Enrollment
478 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
7
States / cities
Palo Alto, California • Miami, Florida • Macon, Georgia + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2019 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome

NCT00100425
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Viceral Perception Testing
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 72 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2000
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 28, 2026, 11:30 AM EDT
Recruiting Early Phase 1 Interventional

Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

NCT06684470
View directory record Official record
Conditions
IBS - Irritable Bowel Syndrome, Diarrhea
Interventions
Mirtazapine, Placebo
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Phase 4 Interventional Results available

A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children

NCT02435069
View directory record Official record
Conditions
Fecal Incontinence, Neurogenic Bowel
Interventions
Dose Response - NS and USP Glycerin - First Intervention, Effectiveness - NS and USP Glycerin - Second Intervention
Drug
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
3 Years to 12 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional Results available

Open Label Seroquel (Quetiapine) Study for Treatment Resistant Functional Bowel Disorder

NCT00617396
View directory record Official record
Conditions
Functional Bowel Disorders
Interventions
Quetiapine (50 mg/day-100mg/day)
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 60 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2017 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Phase 3 Interventional Results available

Long Term Safety Study of Plecanatide

NCT02706483
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Plecanatide
Drug
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
2,272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
204
States / cities
Athens, Alabama • Birmingham, Alabama • Dothan, Alabama + 200 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Oct 28, 2026, 11:30 AM EDT
Terminated Phase 1 Interventional

Pilot Study to Assess the Effects of AV608 on Irritable Bowel Syndrome

NCT00316550
View directory record Official record
Conditions
Irritable Bowel Syndrome (IBS)
Interventions
AV608
Drug
Lead sponsor
Avera Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 25, 2008 · Synced Oct 28, 2026, 11:30 AM EDT
Completed No phase listed Observational

Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer

NCT00410618
View directory record Official record
Conditions
Cognitive/Functional Effects, Colorectal Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Interventions
cognitive assessment, magnetic resonance imaging, management of therapy complications
Procedure
Lead sponsor
University of Arizona
Other
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 6, 2018 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mediterranean Diet and the Gut Microbiome

NCT03269032
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
American Diet, Mediterranean-style Diet
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional Results available

Safety, Efficacy, and Dosing of Stereotactic Radiosurgery for Hepato-cellular Carc/Colo-rectal Liver Metastases

NCT01528878
View directory record Official record
Conditions
Liver Neoplasms, Colonic Neoplasms, Metastatic Cancer to Liver
Interventions
Stereotactic Radiosurgery using the CyberKnife System.
Radiation
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional

Harnessing Placebo Effects: Non-Deceptive Use of Placebo in Irritable Bowel Syndrome (IBS)

NCT01010191
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Sugar pill
Other
Lead sponsor
Harvard University Faculty of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2011 · Synced Oct 28, 2026, 11:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

AcuGraph and Digestive Symptoms

NCT00846794
View directory record Official record
Conditions
Digestive Disorders, Irritable Bowel Syndrome, Constipation, Diarrhea
Interventions
Not listed
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study On The Effect Of GW876008 On Cerebral Blood Flow In Irritable Bowel Syndrome (IBS) Patients And Healthy Volunteers

NCT00376896
View directory record Official record
Conditions
Irritable Colon, Irritable Bowel Syndrome (IBS)
Interventions
GW876008 200mcg, GW876008 20mcg, Placebo
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing Uniqueness of Inflammatory Bowel Disease Related Microbiome-derived Biomarkers

NCT05640583
View directory record Official record
Conditions
Irritable Bowel Disease
Interventions
Hygieacare System
Device
Lead sponsor
HyGIeaCare, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 28, 2026, 11:30 AM EDT
Completed Not applicable Interventional Results available

Irritable Bowel Syndrome Hypnotherapy

NCT01248013
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
gut focused hypnotherapy
Behavioral
Lead sponsor
Mind-Body Digestive Center
Other
Eligibility
20 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2011 · Synced Oct 28, 2026, 11:30 AM EDT