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ClinicalTrials.gov public records Last synced Nov 10, 2026, 2:04 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 55 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Functional Mitral Regurgitation Clear all

Conditions: Mitral Regurgitation, Mitral Valve Regurgitation, Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects, Heart Failure
Interventions: MitraClip System; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 776 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2024
U.S. locations: 81
States / cities: Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 65 more

Conditions: Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Interventions: Edwards PASCAL System, Abbott Mitraclip System; Device
Lead sponsor: Edwards Lifesciences; Industry
Eligibility: 18 Years and older
Enrollment: 1,247 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2031
U.S. locations: 63
States / cities: Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 50 more

Conditions: Depression, Depression Bipolar
Interventions: Not listed
Lead sponsor: Emory University; Other
Eligibility: 35 Years to 65 Years
Enrollment: 169 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Visual Snow Syndrome, Migraine, Healthy
Interventions: Visual Adaptation, Assessments and Questionnaires, Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Imaging (MRS); Behavioral · Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 60 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cardiomyopathy, Cardiovascular Diseases, Congestive Heart Failure, Coronary Artery Disease, Heart Disease, Valvular Heart Disease, Mitral Valve Disease
Interventions: Undersizing Mitral Annuloplasty, Papillary Muscle Approximation; Procedure
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Non-invasive Neuromodulation in Healthy Subjects
Interventions: Inhibitory rTMS (1 Hz), Excitatory rTMS (5 Hz); Device
Lead sponsor: University of Minnesota; Other
Eligibility: 21 Years to 40 Years · Male only
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Aortic Valve Insufficiency, Mitral Valve Insufficiency
Interventions: Not listed
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: Not listed
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1992 – 2001
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
Interventions: Edwards Cardioband System, Guideline Directed Medical Therapy; Device · Drug
Lead sponsor: Edwards Lifesciences; Industry
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 24
States / cities: Los Angeles, California • Palo Alto, California • Aurora, Colorado + 18 more

Conditions: Mitral Valve Regurgitation, Congestive Heart Failure, Cardiomyopathy
Interventions: 3 dimensional echocardiography; Procedure
Lead sponsor: Juan Crestanello, MD; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Atrial Functional Mitral Regurgitation, Mitral Insufficiency
Interventions: Not listed
Lead sponsor: University Hospital of Cologne; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2035
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Functional Mitral Regurgitation, Heart Failure
Interventions: Mitral Loop Cerclage Annuloplasty; Device
Lead sponsor: Tau-MEDICAL Co., Ltd.; Industry
Eligibility: 20 Years to 85 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Major Depressive Disorder
Interventions: 5-Hydroxytryptophan 100 MG, Creatine monohydrate, placebo matched to 5-HTP, Placebo; Drug
Lead sponsor: University of Utah; Other
Eligibility: 25 Years to 40 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Mitral Valve Regurgitation (Degenerative or Functional)
Interventions: INNOVALVE system; Device
Lead sponsor: Edwards Lifesciences; Industry
Eligibility: 18 Years and older
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2034
U.S. locations: 21
States / cities: Los Angeles, California • Palo Alto, California • Naples, Florida + 15 more

Conditions: Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions: Percutaneous mitral valve repair using MitraClip implant; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 2
States / cities: Evanston, Illinois • Indianapolis, Indiana

Conditions: Cardiac Resynchronization Therapy, Heart Failure
Interventions: Postero-lateral, Antero-Lateral; Procedure
Lead sponsor: Sergio Thal, M.D.; Federal
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 2
States / cities: Tucson, Arizona • Lexington, Kentucky

Conditions: Elderly, Pre-diabetic
Interventions: Acute Exercise; Other
Lead sponsor: Duke University; Other
Eligibility: 60 Years to 80 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Functional Mitral Regurgitation
Interventions: Transcatheter mitral valve repair; Device
Lead sponsor: Polares Medical SA; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Healthy
Interventions: Not listed
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2012
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Failure, Mitral Disease, Valve Heart Disease, Valve Disease, Heart
Interventions: Transcatheter Mitral Valve Replacement; Device
Lead sponsor: Caisson Interventional LLC; Industry
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Stenosis, Aortic Valve Regurgitation, Mitral Valve Stenosis, Coronary Artery Bypass Graft Triple Vessel
Interventions: Ambulation orderly; Procedure
Lead sponsor: Baystate Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Springfield, Massachusetts

Conditions: HIV Associated Neurocognitive Disorder
Interventions: Fluconazole, Paroxetine, Paroxetine and Fluconazole, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
Interventions: AltaValve; Device
Lead sponsor: 4C Medical Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 12
States / cities: Tucson, Arizona • Thousand Oaks, California • Washington D.C., District of Columbia + 9 more

Conditions: Brain Hypoxia
Interventions: Mild Hypoxia; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 40 Years · Male only
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Symptomatic Functional MR 3 or Greater
Interventions: This study will evaluate the safety and functionality of the AMEND™ Trans-Septal System for annuloplasty as a therapy for mitral regurgitation.; Device
Lead sponsor: Valcare Medical Ltd.; Industry
Eligibility: 21 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 11
States / cities: Phoenix, Arizona • La Jolla, California • Atlanta, Georgia + 8 more

Search by objective public record fields.

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS

Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial

Magnetic Resonance Spectroscopy (MRS) in Midlife Depression

Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

Improving Mitral Repair for Functional Mitral Regurgitation

Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity

Investigation of Heart Function in Patients With Heart Valve Defects

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy

Assessment of Transcatheter Edge-to-Edge Repair in Atrial Functional Mitral Regurgitation (ATRIAL-MR)

Mitral Loop Cerclage(MLC) for Reducing Functional Mitral Regurgitation

5-HTP and Creatine for Depression

TVMR With the INNOVALVE System Trial - Early Feasibility Study

EVEREST II Pivotal Study High Risk Registry (HRR)

POsition of Leads in Advanced heaRt Failure: the POLAR Study

The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function

Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation ( EXPLORE FMR )

Study of New Magnetic Resonance Methods

Caisson Transcatheter Mitral Valve Replacement (TMVR)

Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study

Study of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive Disorder

AltaValve Early Feasibility Study Protocol

Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

AMEND TS Early Feasibility Study