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ClinicalTrials.gov public records Last synced Oct 9, 2026, 4:51 PM EDT

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Showing 49–72 of 451 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: GERD Gastroesophageal Reflux Disease Clear all
Completed Not applicable Interventional

Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children

NCT00382850
View directory record Official record
Conditions
Gastroesophageal Reflux
Interventions
Nissen fundoplication
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 24 Months
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 1, 2018 · Synced Oct 9, 2026, 4:51 PM EDT
Not yet recruiting Not applicable Interventional

EPX-HTG for Structural Heart Procedures

NCT07705425
View directory record Official record
Conditions
Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation
Interventions
Left Atrial Appendage Occlusion, Mitral Valve Transcatheter Edge to Edge Repair
Device
Lead sponsor
EchoPixel, Inc.
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 9, 2026, 4:51 PM EDT
Withdrawn Not applicable Interventional

In Infants With Laryngomalacia, Does Acid-Blocking Medication Improve Respiratory Symptoms?

NCT02700087
View directory record Official record
Conditions
Laryngomalacia, Acid Reflux, Stridor
Interventions
ranitidine or famotidine, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
Up to 4 Months
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2017 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Phase 1 Interventional Results available

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Vonoprazan in Adolescents With Symptomatic Gastroesophageal Reflux Disease

NCT05343364
View directory record Official record
Conditions
Gastroesophageal Reflux
Interventions
Vonoprazan
Drug
Lead sponsor
Phathom Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
10
States / cities
Mobile, Alabama • Little Rock, Arkansas • Anaheim, California + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Oct 9, 2026, 4:51 PM EDT
Not listed Phase 1Phase 2 Interventional

Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2

NCT04846010
View directory record Official record
Conditions
Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder), Post-Infectious Arthritis, Post-Infectious Polyneuritis, Post-Infectious Parkinsonism, Post-Infectious Hypothyroidism, Post Infectious Osteoarthritis, Anxiety Disorders, Depression, Depression, Anxiety, Depression, Bipolar, Insomnia, GERD, Gastro Esophageal Reflux, Hepatitis, Glomerulonephritis
Interventions
PurWet, FurFat, PurApo, PurPhl, PurClo, PurInf, Smoliv
Combination Product
Lead sponsor
All Natural Medicine Clinic, LLC
Other
Eligibility
Not listed
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated May 26, 2021 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Extraesophageal Reflux With the Reza Band UES Assist Device

NCT01857713
View directory record Official record
Conditions
Laryngopharyngeal Reflux
Interventions
Reza Band UES Assist Device
Device
Lead sponsor
Somna Therapeutics, L.L.C.
Industry
Eligibility
18 Years and older
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
5
States / cities
New York, New York • Nashville, Tennessee • Milwaukee, Wisconsin + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2015 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Phase 1 Interventional

Twice Daily Prevacid for the Treatment of Laryngopharyngeal Reflux

NCT00864396
View directory record Official record
Conditions
Laryngopharyngeal Reflux
Interventions
Prevacid
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Oct 9, 2026, 4:51 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Fundoplication in Laparoscopic PEH Repair Based on FLIP

NCT05807763
View directory record Official record
Conditions
Paraesophageal Hernia
Interventions
Laparoscopic paraesophageal hernia repair without fundoplication
Procedure
Lead sponsor
The Foundation for Surgical Innovation and Education
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
2
States / cities
Evanston, Illinois • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Oct 9, 2026, 4:51 PM EDT
Withdrawn Phase 4 Interventional

Dexilant Treatment in Gastrointestinal Reflux Disease (GERD Related Non Cardiac Chest Pain

NCT01637571
View directory record Official record
Conditions
Chest Pain, Gastrointestinal Reflux Disease
Interventions
Dexilant, Dexilant Placebo
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 11, 2012 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Not applicable Interventional

Study to Evaluate the Effect of a Very Low Carbohydrate Diet on Gastroesophageal Reflux Disease

NCT00998244
View directory record Official record
Conditions
Gastroesophageal Reflux Disease, Overweight, Acid Reflux Disease
Interventions
Diet - very low carb or low fat
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 9, 2012 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Not applicable Interventional Results available

EndoMAXX Endoluminal Valve Technology (EVT) Compared to EndoMAXX

NCT02159898
View directory record Official record
Conditions
Malignant Esophageal Strictures
Interventions
EndoMAXX Endoluminal Valve Technology (EVT), EndoMAXX
Device
Lead sponsor
Merit Medical Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
7
States / cities
Aurora, Colorado • Gainesville, Florida • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Oct 9, 2026, 4:51 PM EDT
Recruiting No phase listed Observational

Indiana University Gastrointestinal Motility Diagnosis Registry

NCT04506593
View directory record Official record
Conditions
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting, Irritable Bowel Syndrome (IBS), Constipation, Chronic Intestinal Pseudo-obstruction, Fecal Incontinence, Small Intestinal Bacterial Overgrowth
Interventions
no intervention
Other
Lead sponsor
Indiana University
Other
Eligibility
Not listed
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Not applicable Interventional

Telehealth-Delivered Gut-Directed Hypnotherapy for Managing GI Health

NCT06890663
View directory record Official record
Conditions
Gastrointestinal Disease, Gastrointestinal Disorders, Nervous System
Interventions
Nonspecific Hypnotherapy for Relaxation, Gut-Directed Hypnotherapy (GDH), 3-month Follow-Up
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Dx-pH Probe in Diagnosing Extra-esophageal Reflux Disease

NCT00388453
View directory record Official record
Conditions
GERD, Larynx Disease
Interventions
Dx-pH Probe, Manometry
Device · Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Oct 9, 2026, 4:51 PM EDT
Completed No phase listed Observational

Proton Pump Inhibitor (PPI) Responsive Eosinophilic Esophagitis EoE: Gastroesophageal Reflux Disease (GERD) or Eosinophilic Esophagitis (EoE)?

NCT01865825
View directory record Official record
Conditions
Erosive Esophagitis
Interventions
Esophageal Barium Xray
Radiation
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 22, 2017 · Synced Oct 9, 2026, 4:51 PM EDT
Terminated Not applicable Interventional Results available

Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus

NCT01129778
View directory record Official record
Conditions
Barrett Esophagus, Gastroesophageal Reflux
Interventions
Zegerid (proton pump inhibitor), Bravo pH monitoring
Drug · Procedure
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 6, 2017 · Synced Oct 9, 2026, 4:51 PM EDT
Terminated No phase listed Observational

Gastroesophageal Reflux Disease Prospective Registry

NCT02479438
View directory record Official record
Conditions
GERD
Interventions
Diagnosed with GERD
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
744 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 9, 2026, 4:51 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Study of Tooth Erosion in People With Esophagogastric Cancer

NCT05612048
View directory record Official record
Conditions
Esophagogastric Cancer
Interventions
Survey, Intra-oral camera, Optional Salvia sample
Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 9, 2026, 4:51 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Rabeprazole in Infants With Gastroesophageal Erosive Reflux Disease (GERD)

NCT00992589
View directory record Official record
Conditions
Gastroesophageal Reflux
Interventions
Rabeprazole sodium 5 mg, Rabeprazole sodium 10 mg, Placebo
Drug
Lead sponsor
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Industry
Eligibility
1 Month to 11 Months
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
43
States / cities
Birmingham, Alabama • Columbiana, Alabama • Dothan, Alabama + 40 more
Source: ClinicalTrials.gov public record
Updated May 22, 2013 · Synced Oct 9, 2026, 4:51 PM EDT
Terminated Not applicable Interventional Results available

Retrospective TIF Study for Treatment of Gastroesophageal Reflux Disease (GERD). The RetroTIF Study

NCT01327963
View directory record Official record
Conditions
Gastroesophageal Reflux Disease (GERD)
Interventions
Transoral Incisionless Fundoplication
Device
Lead sponsor
EndoGastric Solutions
Industry
Eligibility
18 Years to 85 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Ocala, Florida • Salem, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Oct 9, 2026, 4:51 PM EDT
Completed No phase listed Observational

The Bronx-Valve Registry

NCT05453526
View directory record Official record
Conditions
Valvular Heart Disease
Interventions
Not listed
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
330,570 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Oct 9, 2026, 4:51 PM EDT
Recruiting Phase 4 Interventional

Famotidine and Antacids for Treatment of Dyspepsia

NCT06241183
View directory record Official record
Conditions
Dyspepsia, GERD, Acid Reflux
Interventions
Intravenous Famotidine, Oral Maalox/ Mylanta
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 9, 2026, 4:51 PM EDT
Terminated Not applicable Interventional Results available

Management of Reflux After Sleeve Using Stretta

NCT02637713
View directory record Official record
Conditions
GERD, Morbid Obesity
Interventions
Stretta, Radiofrequency (RF) Energy to the LES (Stretta Procedure)
Device · Procedure
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
13
States / cities
Los Angeles, California • Stanford, California • Norwalk, Connecticut + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Oct 9, 2026, 4:51 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Outcome Analysis of POEM and Endoluminal Therapies

NCT03123835
View directory record Official record
Conditions
Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer, Stenoses, Gastric Nec
Interventions
Endoscopic Intervention
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2031
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 9, 2026, 4:51 PM EDT