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Showing 1–24 of 593 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: GI Tract Disorders Clear all
Completed No phase listed Observational

Comparison of Gut Microbiota, Inflammation and Symptoms Following Allogeneic HSCT

NCT02398708
View directory record Official record
Conditions
Graft vs Host Disease, Graft Versus Host Disease, Hematopoietic Stem Cell Transplantation, Peripheral Blood Stem Cell Transplantation
Interventions
Questionnaires, Blood Sample, Stool Sample, Clinical data
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 24, 2019 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors

NCT03032640
View directory record Official record
Conditions
Obesity
Interventions
Oral Glucose Tolerance Test (OGTT), Assessment of dietary compliance, Stool sampling, Sodium Saccharin, Placebo, Lactisole
Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 45 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Jun 27, 2026, 7:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

NCT06139224
View directory record Official record
Conditions
Alcohol Use Disorder, Human Immunodeficiency Virus
Interventions
4 week prebiotic consumption, 4 week placebo consumption
Dietary Supplement · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Defining Adolescent Nausea Through Brain Imaging and Neurostimulation Response

NCT03675321
View directory record Official record
Conditions
Functional Gastrointestinal Disorders
Interventions
Active Auricular Neurostimulation, Sham Auricular Neurostimulation
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
11 Years to 18 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jun 27, 2026, 7:22 AM EDT
Completed No phase listed Observational

Environmental Health Effects on Your Physiology

NCT03986814
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 25 Years
Enrollment
92 participants
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Phase 1Phase 2 Interventional

Effect of TU-100 on Rectal Compliance, Rectal Sensation and Small Bowel and Colonic Transit in Females With Constipation

NCT01139216
View directory record Official record
Conditions
Functional Constipation, Gastric Emptying, Whole Gut Transit, Small Bowel Transit, Colonic Transit, Rectal Compliance, Rectal Sensation
Interventions
Daikenchuto (TU-100), Placebo
Drug
Lead sponsor
Tsumura USA
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2013 · Synced Jun 27, 2026, 7:22 AM EDT
Withdrawn Phase 1 Interventional

Fecal Microbiota Transplantation for the Treatment of Severe Acute Gut Graft-Versus-Host Disease

NCT04280471
View directory record Official record
Conditions
Acute Graft Versus Host Disease, Gastrointestinal Tract Acute Graft Versus Host Disease, Severe Gastrointestinal Tract Acute Graft Versus Host Disease, Steroid Resistant Gastrointestinal Tract Acute Graft Versus Host Disease
Interventions
Fecal Microbiota Transplantation Capsule
Drug
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Jun 27, 2026, 7:22 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.

NCT07505212
View directory record Official record
Conditions
Obesity (Disorder)
Interventions
Gallotannin-rich mango, Lactiplantibacillus pentosus (probiotic), No Treatment Added
Dietary Supplement · Other
Lead sponsor
Prairie View A&M University
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Prairie View, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jun 27, 2026, 7:22 AM EDT
Terminated Phase 2 Interventional Results available

Pembrolizumab and EDP1503 in Advanced Melanoma

NCT03595683
View directory record Official record
Conditions
Melanoma (Skin), Melanoma
Interventions
Pembrolizumab, EDP1503
Drug · Biological
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Jun 27, 2026, 7:22 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Brain-Gut Interactions in Overweight and Normal Weight Patients With Chronic Abdominal Pain

NCT00824941
View directory record Official record
Conditions
Obesity, Stress, Irritable Bowel Syndrome, Women, Abdominal Pain
Interventions
Not listed
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
13 Years to 45 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2019 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Not applicable Interventional

The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients

NCT04111471
View directory record Official record
Conditions
Microbial Colonization
Interventions
Prebiotics, Placebos
Dietary Supplement
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
2 Years to 18 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Not applicable Interventional

A Clinical Study to Assess the Physiologic Effects of KB109 in Patients With COVID-19 on Gut Microbiota Structure and Function

NCT04486482
View directory record Official record
Conditions
Mild-to-Moderate COVID-19
Interventions
KB109 + Self Supportive Care (SSC), Self Supportive Care (SSC) Alone
Other
Lead sponsor
Kaleido Biosciences
Industry
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
12
States / cities
Cullman, Alabama • Los Angeles, California • Rancho Cucamonga, California + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2021 · Synced Jun 27, 2026, 7:22 AM EDT
Not yet recruiting Early Phase 1 Interventional

Use of A Complex Gut Bacterial Consortium (MITI 001) for the Treatment of Irritable Bowel Syndrome With Diarrhea

NCT07238790
View directory record Official record
Conditions
IBS (Irritable Bowel Syndrome), Diarrhea
Interventions
MITI-001 administration
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
Redwood City, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jun 27, 2026, 7:22 AM EDT
Recruiting Phase 2 Interventional

Trial Targeting Gut Bacterial Androgen Production to Reverse Therapeutic Resistance to Abiraterone in Patients With Metastatic Prostate Cancer

NCT06616597
View directory record Official record
Conditions
Prostate Cancer (Adenocarcinoma), Metastatic Prostate Cancer
Interventions
Abiraterone acetate, Dexamethasone, Metronidazole
Drug
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older · Male only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Jun 27, 2026, 7:22 AM EDT
Not listed Phase 1Phase 2 Interventional

A Study of the Efficacy of Cannabidiol in Patients With Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies

NCT03607643
View directory record Official record
Conditions
Cancer of Pancreas, Cancer of Liver, Cancer of Rectum, Cancer of Colon, Cancer, Gall Bladder, Myeloma Multiple, Glioblastoma Multiforme
Interventions
Cannabidiol, Bortezomib, Leucovorin, 5-FU, Oxaliplatin, Bevacizumab, Irinotecan, Gemcitabine, Temozolomide
Drug
Lead sponsor
Leaf Vertical Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Autologous Fecal Therapy

NCT02046525
View directory record Official record
Conditions
Infectious Disease of Digestive Tract
Interventions
Autologous fecal microbiota therapy, Placebo
Biological · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Evaluation of a PillCam Colon Bowel Preparation Regimen in Crohn's Disease Patients

NCT01576120
View directory record Official record
Conditions
Crohn's Disease
Interventions
bowel prep regimen first boost 6 oz. and second boost 3 oz., bowel prep regimen first boost 3 oz. and second boost 6 oz.
Other
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Atlanta, Georgia • Beavercreek, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Jun 27, 2026, 7:22 AM EDT
Recruiting Phase 1 Interventional

A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors

NCT07229313
View directory record Official record
Conditions
Advance Solid Tumors
Interventions
KIVU-107
Drug
Lead sponsor
Kivu Bioscience Inc.
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Happy Gut Study - Fermented Vegetables and Cardiovascular Biomarkers

NCT04887662
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
Fermented vegetable
Other
Lead sponsor
University of North Florida
Other
Eligibility
35 Years to 64 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 21, 2024 · Synced Jun 27, 2026, 7:22 AM EDT
Terminated No phase listed Observational

Gut and Tumor Microbiome in Patients With Early Stage (II-III), Locally Advanced or Advanced ER-positive and HER2-negative Breast Cancer.

NCT06126003
View directory record Official record
Conditions
Breast Cancer
Interventions
Observation
Other
Lead sponsor
BioCorteX Inc
Industry
Eligibility
18 Years to 85 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
6
States / cities
Decatur, Illinois • Las Vegas, Nevada • Belleville, New Jersey + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2024 · Synced Jun 27, 2026, 7:22 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Personalized Immunotherapy in Adults With Upper Gastrointestinal Tract Cancers

NCT05153304
View directory record Official record
Conditions
Cancer of Gastrointestinal Tract
Interventions
personalized vaccine, Nivolumab
Biological · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 9, 2024 · Synced Jun 27, 2026, 7:22 AM EDT
Completed Phase 2 Interventional Results available

NBT-NM108 as an Early Treatment for Suspected or Confirmed Symptomatic COVID-19 Patients

NCT04540406
View directory record Official record
Conditions
Suspected or Confirmed COVID-19
Interventions
NBT-NM108, Usual Care Only
Drug · Other
Lead sponsor
Notitia Biotechnologies Company
Industry
Eligibility
18 Years to 79 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Jun 27, 2026, 7:22 AM EDT
Terminated Not applicable Interventional

Human Breastmilk in Young Children With Norovirus Infection of the Gut

NCT02371538
View directory record Official record
Conditions
Norovirus Infections
Interventions
Donor Breastmilk
Dietary Supplement
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Not listed
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Jun 27, 2026, 7:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The COLIC Study: Colonization of the Infant Gut With B. Infantis EVC001 to Reduce Symptoms of Colic

NCT05129384
View directory record Official record
Conditions
Infantile Colic
Interventions
B. infantis EVC001 or Lactose Placebo
Dietary Supplement
Lead sponsor
Evolve BioSystems, Inc.
Industry
Eligibility
14 Days to 42 Days
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 28, 2022 · Synced Jun 27, 2026, 7:22 AM EDT