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ClinicalTrials.gov public records Last synced Nov 10, 2026, 3:39 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Gastrointestinal Discomfort Clear all

Conditions: Upper Gastrointestinal Discomfort
Interventions: Mānuka Honey Active Product 1, Mānuka Honey Active Product 2, Placebo Control; Other
Lead sponsor: Radicle Science; Industry
Eligibility: 21 Years to 105 Years
Enrollment: 775 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Del Mar, California

Conditions: Gastrointestinal Discomfort, Bloating
Interventions: Active: Multi-strain probiotic dietary supplement, Placebo: Placebo; Dietary Supplement
Lead sponsor: Daily Nouri; Industry
Eligibility: 25 Years to 45 Years · Female only
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Gastrointestinal Disorders (FGIDs), Gastrointestinal and Digestive Disorder, Abdominal Pain/ Discomfort, Pain, Functional Dyspepsia
Interventions: Guided Imagery Therapy; Behavioral
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 7 Years to 12 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Austin, Texas • Houston, Texas

Conditions: Gut Health
Interventions: Butyrate Formulation, Butyrate + Polyphenol Formulation, Placebo; Dietary Supplement
Lead sponsor: Supplement Formulators, Inc.; Industry
Eligibility: 21 Years to 70 Years
Enrollment: 143 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Gut Health
Interventions: Butyrate + Polyphenol Formulation, Placebo; Dietary Supplement
Lead sponsor: Supplement Formulators, Inc.; Industry
Eligibility: 25 Years to 70 Years
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: General Wellbeing, Gastrointestinal Health, Physical Discomfort, Sleep, Mood
Interventions: Not listed
Lead sponsor: Thorne HealthTech, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 201 participants
Timeline: 2020
U.S. locations: 1
States / cities: Summerville, South Carolina

Conditions: Pain, Anal Cancer
Interventions: Perianal Exam, high-resolution anoscopy (HRA) with biopsy; Procedure
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Abdominal Pain/ Discomfort, Irritable Bowel Syndrome
Interventions: Music intervention; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Bloating, Digestive Discomfort, Irritable Bowel Syndrome (IBS), Flatulence, Constipation, Gut Health
Interventions: Intervention, Placebo; Dietary Supplement
Lead sponsor: JS Health & Vitamins; Industry
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Crohn's Disease (CD), Dysmenorrhea Primary
Interventions: Acetaminophen, Ibuprofen; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Gastrointestinal Discomfort, Gastrointestinal Side Effects of GLP-1 Receptor Agonist Use, Nausea, Abdominal Pain, Bloating, Diarrhea, Constipation
Interventions: Placebo, Oxxynea® Supplement; Dietary Supplement
Lead sponsor: AB Mauri (UK) Limited,; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Gastrointestinal Disorders, Functional Colonic Disease, Gastrointestinal Disease, Digestive System Diseases, Neurological Manifestations, Signs and Symptoms, Digestive, Pain, Abdominal Pain/ Discomfort
Interventions: Guided Imagery Therapy; Behavioral
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 7 Years to 12 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Lactose Intolerants, Lactose Malabsorption, Caseins
Interventions: A1/A2 milk with oral naloxone, A1PF milk with oral naloxone; Other
Lead sponsor: Purdue University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: West Lafayette, Indiana

Conditions: Gastrointestinal Symptoms, Bloating, Digestive Discomfort, Low Energy Levels, Brain Fog, Mood Instability, Sleep Quality, Skin Clarity, Facial Puffiness, Bad Breath
Interventions: Super Liver; Dietary Supplement
Lead sponsor: SuperBonsai Inc.; Industry
Eligibility: 30 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Healthy
Interventions: Mushroom blend, Placebo; Dietary Supplement · Other
Lead sponsor: University of South Carolina; Other
Eligibility: 30 Years to 60 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Diabetic Gastroparesis
Interventions: TEA, Sham-TEA; Device
Lead sponsor: Transtimulation Research, Inc; Other
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 2
States / cities: Jackson, Mississippi • El Paso, Texas

Conditions: Gastrointestinal Discomfort, Digestive Well Being, Gut-related Symptoms
Interventions: Food ingredient of oyster mushroom mycelium (Pleurotus pulmonarius) and microalgae (Chlorella vulgaris); Dietary Supplement
Lead sponsor: Koralo GmbH; Industry
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Healthy, Gastrointestinal Discomfort
Interventions: Encapsulated Calcium Butyrate; Dietary Supplement
Lead sponsor: Kemin Foods LC; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Addison, Illinois

Conditions: Moderate Gastrointestinal Discomfort
Interventions: BIOHM FX Probiotic Blend; Dietary Supplement
Lead sponsor: Biohm Technologies; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 141 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Dyspepsia
Interventions: dexloxiglumide, Nexium (esomeprazole); Drug
Lead sponsor: Forest Laboratories; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Gastrointestinal Discomfort
Interventions: I3.1, Placebo treatment; Dietary Supplement
Lead sponsor: University of Memphis; Other
Eligibility: 20 Years to 50 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Menstrual Discomfort
Interventions: Probiotic, Placebo; Dietary Supplement
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 35 Years · Female only
Enrollment: 187 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Healthy Participants, Upper Gastrointestinal Discomfort
Interventions: Limosilactobacillus reuteri DSM 17648, Placebo; Dietary Supplement
Lead sponsor: Novozymes A/S; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 324 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Digestive Discomfort
Interventions: Dietary Supplement: conventional cow's milk consumption, and then A1PF milk consumption, Dietary Supplement: A1PF milk consumption, and then conventional cow's milk consumption; Other
Lead sponsor: a2 Milk Company Ltd.; Industry
Eligibility: 18 Years to 68 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Search by objective public record fields.

Impact of Lepteridine™ Mānuka Honey in Adults With Gastrointestinal Discomfort

Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women

Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children

Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

A Study to Evaluate the Effects of a Butyrate-Polyphenol Formulation on Gut Health and Associated Symptoms

Hemp Oil + User Experience Study

High-Resolution Anoscopy Perceived Discomfort Study

The Mechanism Underlying the Analgesic Effect of the Music of IBS Pain

A Clinical Trial to Examine the Effects of Gut Health Supplements to Improve Gut and Digestive Health and Function

Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)

A Study to Evaluate the Effects of a Supplement on Gut Comfort in GLP-1 Receptor Agonist Users

Efficacy of Guided Imagery Therapy Mobile Application for Functional Abdominal Pain

Milk Beta Caseins on Digestive Discomfort, Gastric Emptying

A Clinical Trial to Evaluate the Effects of Super Liver Liquid Drops on Gut Health, Digestive Comfort, and Daily Energy Levels

Effects of a Mushroom Blend on Gastrointestinal Symptoms and the Microbiome

Transcutaneous Electroacupuncture for Gastroparesis

Evaluation of Gut-Related Well-Being and Mood Effects of a Daily Nutritional Food Ingredient From the Co-Fermentation of Fungal Mycelium (Pleurotus Pulmonarius) and Microalgae (Chlorella Vulgaris)

Effects of an Encapsulated Calcium Butyrate Dietary Supplement on Gut Health

Investigating the Effectiveness of 2 Different Doses of BIOHM FX Probiotic Blend in Improving Digestive Symptoms

The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.

Safety and Efficacy of a Probiotic Supplement

Probiotic and Gastrointestinal Symptoms Due to Menstruation in Healthy Women

Effect of Limosilactobacillus Reuteri DSM 17648 in Healthy Adults Reporting Upper Gastrointestinal Discomfort

A1 Beta-casein-free Milk in Milk-intolerant Participants