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ClinicalTrials.gov public records Last synced Oct 29, 2026, 11:23 AM EDT

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Showing 1–24 of 613 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Gastrointestinal Microbiota Clear all
Not listed Early Phase 1 Interventional

Fecal Microbiota Transplant in the Treatment of Ulcerative Colitis

NCT02390726
View directory record Official record
Conditions
Ulcerative Colitis, Active Moderate
Interventions
Fecal Microbiota Transplant, Placebo
Biological
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Influence of Oral Probiotics on the Microbiome and Lipidome

NCT03605108
View directory record Official record
Conditions
Gut Microbiome, Skin Microbiome, Gut Lipidome, Skin Lipidome, Blood Lipidome
Interventions
Probiotic, Placebo
Dietary Supplement · Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 12, 2019 · Synced Oct 29, 2026, 11:23 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults

NCT05387876
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Vitamin D intervention, Placebo intervention
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 79 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Oct 29, 2026, 11:23 AM EDT
Active, not recruiting Phase 2 Interventional

Resistant Maltodextrin for Gut Microbiome in Parkinson's Disease: Safety and Tolerability Study

NCT03667404
View directory record Official record
Conditions
Parkinson Disease, Intestinal Bacteria Flora Disturbance, Dietary Modification
Interventions
Resistant maltodextrin, maltodextrin
Dietary Supplement
Lead sponsor
Northwestern University
Other
Eligibility
60 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 29, 2026, 11:23 AM EDT
Withdrawn Phase 2 Interventional

OMega-3 Fatty Acid for the Immune Modulation of Colorectal Cancer

NCT03661047
View directory record Official record
Conditions
Colon Cancer
Interventions
AMR101 (VASCEPA, icosapent ethyl)
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2021 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sucralose, Stevia, Gut Microbiome and Glucose Metabolism

NCT02800707
View directory record Official record
Conditions
Impaired Glucose Tolerance
Interventions
Sucralose, Stevia
Other
Lead sponsor
University of Minnesota
Other
Eligibility
35 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Role of Dietary Intake and Host Genetics in Gut Microbiome Response to Resistant Starch Consumption

NCT05743790
View directory record Official record
Conditions
Healthy Volunteers
Interventions
RS2-control-RS4, RS4-control-RS2
Dietary Supplement
Lead sponsor
Cornell University
Other
Eligibility
18 Years and older
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Oral Probiotics and Herbal Supplementation on the Gut Microbiome and Sebum Excretion Rate in Non-Cystic Acne

NCT05919810
View directory record Official record
Conditions
Acne Vulgaris, Acneiform Eruptions, Skin Diseases, Sebaceous Gland Diseases
Interventions
Probiotic, Oral herbal powder supplement
Other · Dietary Supplement
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
12 Years to 45 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Oct 29, 2026, 11:23 AM EDT
Recruiting Not applicable Interventional

Effect of Watermelon on Gut and Cardiometabolic Health

NCT06588218
View directory record Official record
Conditions
Obesity and Overweight, Dysbiosis
Interventions
Watermelon, Belvita Breakfast Sandwich + 12 oz Water
Other
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 30 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional

Response of the Gut Microbiome and Circulating Metabolome to Diet in Children: Ancillary Study to KIDFIT (NCT03405246)

NCT03612479
View directory record Official record
Conditions
Gastrointestinal Microbiome, Metabolome, Pediatric Obesity, Dietary Approaches to Stop Hypertension
Interventions
KIDFIT Healthy, KIDFIT Safe
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
3 Years to 5 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Oct 29, 2026, 11:23 AM EDT
Not yet recruiting Not applicable Interventional

Open-Label Clinical Trial Evaluating the Impact of a Multi-Strain Commensal Probiotic Dietary Supplement on Gastrointestinal Microbiota Composition, Functional Gastrointestinal Markers, and Gastrointestinal Symptoms

NCT07720362
View directory record Official record
Conditions
Gastrointestinal, Microbiota
Interventions
Complete Commensal Probiotic
Dietary Supplement
Lead sponsor
OvationLab
Network
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional

A Pilot Proof of Concept Study of the Effects of Administration of SCFA in Rheumatoid Arthritis (EASi-RA)

NCT05152615
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Short Chain Fatty Acids (SCFA) Dietary Supplement
Dietary Supplement
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Oct 29, 2026, 11:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Examining the Distal Gut Microbiome After Spinal Cord Injury

NCT03319225
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional

Microbiome, Exercise Tracking Study: Among Individuals at High Risk for Colorectal Cancer

NCT02780284
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Physical activity intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 69 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Oct 29, 2026, 11:23 AM EDT
Recruiting No phase listed Observational

Role of Gut Microbiome in Cancer Therapy

NCT05112614
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Biospecimen Collection, Electronic Health Record Review
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2030
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Phase 2 Interventional Results available

Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans

NCT02037295
View directory record Official record
Conditions
Obesity
Interventions
Vancomycin, Placebo oral tablet, Overfeeding diet (OF), Underfeeding diet (UF)
Drug · Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 45 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 31, 2020 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional

Prebiotics in Peritoneal Dialysis

NCT03265639
View directory record Official record
Conditions
End Stage Renal Disease, Gut Microbiome Dysbiosis
Interventions
P-inulin
Dietary Supplement
Lead sponsor
Ali Ramezani
Other
Eligibility
21 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

First Complementary Foods and the Infant Gastrointestinal Microbiota

NCT05492253
View directory record Official record
Conditions
Healthy Participants, Infants, Gastrointestinal Microbiota
Interventions
Infant fruit, Infant vegetable, Infant meat, Infant grain
Other
Lead sponsor
University of Delaware
Other
Eligibility
5 Months to 7 Months
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 17, 2024 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Dietary Fiber on Fecal Microbiota and Metabolism

NCT01518088
View directory record Official record
Conditions
Focus of the Study is on Gut Health
Interventions
Dietary Fiber
Dietary Supplement
Lead sponsor
Ingredion Incorporated
Industry
Eligibility
20 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2016 · Synced Oct 29, 2026, 11:23 AM EDT
Recruiting No phase listed Observational

Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury

NCT05670288
View directory record Official record
Conditions
Spinal Cord Injuries, Gut Microbiome
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Human Pilot Study - HA35 (Hyaluronan Molecular Weight 35) Dietary Supplement for Promoting Intestinal Health

NCT02867605
View directory record Official record
Conditions
Gastrointestinal Microbiome
Interventions
Hyaluronan
Dietary Supplement
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Fermented Vegetables on Gut Microflora and Inflammation in Women

NCT03407794
View directory record Official record
Conditions
Inflammation, Women's Health, Gastrointestinal Microbiome
Interventions
Fermented vegetable, Non-fermented vegetable
Other
Lead sponsor
University of North Florida
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 11, 2023 · Synced Oct 29, 2026, 11:23 AM EDT
Completed Early Phase 1 Interventional

Impact of Probiotics on Oral Microbiota in Older Adults With Dysphagia

NCT03682094
View directory record Official record
Conditions
Dysphagia
Interventions
VSL#3
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
65 Years to 99 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Oct 29, 2026, 11:23 AM EDT