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Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gender Identity Clear all
Suspended Not applicable Interventional

SmokefreeSGM Español Pilot, Beta Testing a Text-based Smoking Cessation Intervention for Sexual and Gender Minority(SGM) Groups Preferring Spanish Language

NCT06487806
View directory record Official record
Conditions
Smoking Cessation
Interventions
SmokefreeSGM
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

TRANSLATE: Transgender and Gender Nonconforming Individuals' Access to Healthcare

NCT03808883
View directory record Official record
Conditions
Gender Identity
Interventions
TGNC Directed Advocacy Meetings, Facilitated Dialogues between TGNC Cohort and Healthcare Participants
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
14 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Sep 5, 2026, 9:06 AM EDT
Completed No phase listed Observational

Psychosocial Needs of YMSM

NCT00710671
View directory record Official record
Conditions
HIV+ YMSM
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 24 Years · Male only
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
14
States / cities
Los Angeles, California • San Francisco, California • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Sep 5, 2026, 9:06 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population

NCT06247267
View directory record Official record
Conditions
Hypogonadism, Gender Identity Dysphoria
Interventions
Fortesta, Estradiol
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Sep 5, 2026, 9:06 AM EDT
Completed No phase listed Observational

Pubertal Blockade and Hormone Therapy in Transgender Youth

NCT03557268
View directory record Official record
Conditions
Gender Identity, Gender Dysphoria, Gender Identity Disorder in Adolescence and Adulthood
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
13 Years to 16 Years · Female only
Enrollment
19 participants
Timeline
2018 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 28, 2020 · Synced Sep 5, 2026, 9:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sexual Orientation and Gender Identity (SOGI) Data Collection Program Implementation and Evaluation

NCT05845476
View directory record Official record
Conditions
Cancer Surveillance
Interventions
Patient SOGI Self-Report, SOGI Resource for Clinical Care Education (SORCE), Cancer Center Care Environment
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Facebook Intervention for Young Sexual and Gender Minority Smokers

NCT03259360
View directory record Official record
Conditions
Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation, Tobacco Smoking, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco
Interventions
POP:, TSP:
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Peer-Oriented HIV Prevention Outreach Program for Individuals at High Risk for HIV and Other STIs

NCT00183456
View directory record Official record
Conditions
HIV Infections, Sexually Transmitted Diseases
Interventions
Peer-oriented intervention, Group cognitive behavioral therapy (CBT)
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 74 Years
Enrollment
746 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 27, 2013 · Synced Sep 5, 2026, 9:06 AM EDT
Recruiting No phase listed Observational

Puberty, Testosterone, and Brain Development

NCT06670053
View directory record Official record
Conditions
Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
Interventions
Testosterone
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 20 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre: Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre

NCT04515654
View directory record Official record
Conditions
Transgenderism, Stigma, Social
Interventions
IDEAS (Identity Evolution and Sharing) Performance
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 16, 2020 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effectiveness Research to Improve the Health of Sexual and Gender Minority Patients Through Cultural Competence and Skill Training of Community Health Center Providers and Non-clinical Staff

NCT03554785
View directory record Official record
Conditions
LGBT Health, Cultural Competency, Education, Sexual Orientation, Gender Identity
Interventions
Clinician and Non-clinician staff training
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sexual and Gender Minority Emerging Adults Eliciting Narratives

NCT05899218
View directory record Official record
Conditions
Mental Health Wellness 1, Sexual Orientation, Gender Identity
Interventions
Critical Narrative Development
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 24 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 24, 2024 · Synced Sep 5, 2026, 9:06 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Transgender Post-reassignment Urogynecologic Measures and Perceptions

NCT03293771
View directory record Official record
Conditions
Gender Identity Disorder of Adult, Voiding Disorders, Sexual Dysfunction
Interventions
Focus group interviews, Questionnaire packet
Other · Diagnostic Test
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Sep 5, 2026, 9:06 AM EDT
Suspended Not applicable Interventional

Improving Alcohol Use Disorder Treatment for Gender Minority Populations

NCT05070793
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Culturally adapted interpersonal psychotherapy
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 5, 2026, 9:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women

NCT04066283
View directory record Official record
Conditions
Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation, Insulin Sensitivity, Blood Pressure, Lipid Disorder, Appetitive Behavior
Interventions
No intervention
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 5, 2026, 9:06 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty

NCT05607303
View directory record Official record
Conditions
Headache, Gender Identity
Interventions
Clinical estrogen therapy
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
9 Years to 20 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Sep 5, 2026, 9:06 AM EDT
Terminated No phase listed Observational

The Relation of GnRH Treatment to QTc Interval in Transgender Females

NCT03078829
View directory record Official record
Conditions
Gender Dysphoria
Interventions
Treatment with a GnRh agonists
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
10 Years and older · Male only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 25, 2018 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers

NCT03553992
View directory record Official record
Conditions
Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation, Tobacco Smoking, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco
Interventions
POP-6:, TSP-6:
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 5, 2026, 9:06 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Gender Identity and Own Body Perception

NCT04374708
View directory record Official record
Conditions
Gender Dysphoria
Interventions
fMRI
Diagnostic Test
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 40 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 5, 2026, 9:06 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Empowering Newcomer Voices: A Trauma-Informed, Gender-Responsive Group Intervention in Schools (VOCES-NUEVAS)

NCT07041931
View directory record Official record
Conditions
Mental Health
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years and older · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 5, 2026, 9:06 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Increasing Effective Mental Health Care for LGBT Clients

NCT05352659
View directory record Official record
Conditions
Sexual Orientation, Gender Identity
Interventions
Face-to-face and online LGBTQ+ training, On-line training
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Sep 5, 2026, 9:06 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Efficacy of a Chronic Pain Treatment Prior to Gender-affirming Surgery

NCT06443164
View directory record Official record
Conditions
Pain Catastrophizing, Pain, Chronic, Gender Identity
Interventions
Empowered Relief, Standard of Care
Behavioral · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Sep 5, 2026, 9:06 AM EDT
Completed Not applicable Interventional

Evaluating the Efficacy of the Parent Support Program

NCT04531761
View directory record Official record
Conditions
Prejudice, Gender Identity, Knowledge, Attitudes, Practice
Interventions
Parent Support Program
Behavioral
Lead sponsor
Palo Alto University
Other
Eligibility
18 Years and older
Enrollment
570 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 5, 2026, 9:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Intervention to Collect and Utilize Sexual Orientation and Gender Identity (SOGI) Information in Hospice

NCT05877391
View directory record Official record
Conditions
Sexual and Gender Minorities, Hospice, Alzheimer's Disease and Related Dementias
Interventions
SGM Communication Intervention
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 23, 2024 · Synced Sep 5, 2026, 9:06 AM EDT