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ClinicalTrials.gov public records Last synced Oct 22, 2026, 8:12 PM EDT

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Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Gender Identity Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Peer-Oriented HIV Prevention Outreach Program for Individuals at High Risk for HIV and Other STIs

NCT00183456
View directory record Official record
Conditions
HIV Infections, Sexually Transmitted Diseases
Interventions
Peer-oriented intervention, Group cognitive behavioral therapy (CBT)
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 74 Years
Enrollment
746 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 28, 2013 · Synced Oct 22, 2026, 8:12 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty

NCT05607303
View directory record Official record
Conditions
Headache, Gender Identity
Interventions
Clinical estrogen therapy
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
9 Years to 20 Years
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 22, 2026, 8:12 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Transgender Cohort Study of Gender Affirmation and HIV-related Health

NCT03595956
View directory record Official record
Conditions
HIV/AIDS, STI, Gender Dysphoria, Transsexualism, Gender Identity, Depression, Anxiety
Interventions
Medical gender affirmation
Other
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older
Enrollment
4,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Oct 22, 2026, 8:12 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Transgender Post-reassignment Urogynecologic Measures and Perceptions

NCT03293771
View directory record Official record
Conditions
Gender Identity Disorder of Adult, Voiding Disorders, Sexual Dysfunction
Interventions
Focus group interviews, Questionnaire packet
Other · Diagnostic Test
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 22, 2026, 8:12 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population

NCT06247267
View directory record Official record
Conditions
Hypogonadism, Gender Identity Dysphoria
Interventions
Fortesta, Estradiol
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 22, 2026, 8:12 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Efficacy of a Chronic Pain Treatment Prior to Gender-affirming Surgery

NCT06443164
View directory record Official record
Conditions
Pain Catastrophizing, Pain, Chronic, Gender Identity
Interventions
Empowered Relief, Standard of Care
Behavioral · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 22, 2026, 8:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sexual Orientation and Gender Identity (SOGI) Data Collection Program Implementation and Evaluation

NCT05845476
View directory record Official record
Conditions
Cancer Surveillance
Interventions
Patient SOGI Self-Report, SOGI Resource for Clinical Care Education (SORCE), Cancer Center Care Environment
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Oct 22, 2026, 8:12 PM EDT
Terminated No phase listed Observational

The Relation of GnRH Treatment to QTc Interval in Transgender Females

NCT03078829
View directory record Official record
Conditions
Gender Dysphoria
Interventions
Treatment with a GnRh agonists
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
10 Years and older · Male only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 26, 2018 · Synced Oct 22, 2026, 8:12 PM EDT
Suspended Not applicable Interventional

SmokefreeSGM Español Pilot, Beta Testing a Text-based Smoking Cessation Intervention for Sexual and Gender Minority(SGM) Groups Preferring Spanish Language

NCT06487806
View directory record Official record
Conditions
Smoking Cessation
Interventions
SmokefreeSGM
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 22, 2026, 8:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effects of Orchiectomy and Age on Vascular and Metabolic Health in Older Versus Younger Transgender Women

NCT05195164
View directory record Official record
Conditions
Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation, Insulin Sensitivity, Blood Pressure, Lipid Disorder, Appetitive Behavior
Interventions
No intervention
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 99 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 8:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men

NCT04237467
View directory record Official record
Conditions
Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation, Blood Pressure, Lipid Disorder, Appetitive Behavior
Interventions
No intervention
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Facebook Intervention for Young Sexual and Gender Minority Smokers

NCT03259360
View directory record Official record
Conditions
Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation, Tobacco Smoking, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco
Interventions
POP:, TSP:
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 22, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effectiveness Research to Improve the Health of Sexual and Gender Minority Patients Through Cultural Competence and Skill Training of Community Health Center Providers and Non-clinical Staff

NCT03554785
View directory record Official record
Conditions
LGBT Health, Cultural Competency, Education, Sexual Orientation, Gender Identity
Interventions
Clinician and Non-clinician staff training
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2023 · Synced Oct 22, 2026, 8:12 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

THE GUIDE: Transforming Health for Young Adults Using Interventions to Drive Engagement

NCT06177600
View directory record Official record
Conditions
Transgender Persons, Health Services for Transgender Persons, Gender Identity
Interventions
Interactive educational digital platform for transgender and gender-diverse (TGD) young adults and caregivers
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 29 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 22, 2026, 8:12 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Increasing Effective Mental Health Care for LGBT Clients

NCT05352659
View directory record Official record
Conditions
Sexual Orientation, Gender Identity
Interventions
Face-to-face and online LGBTQ+ training, On-line training
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Oct 22, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sexual and Gender Minority Emerging Adults Eliciting Narratives

NCT05899218
View directory record Official record
Conditions
Mental Health Wellness 1, Sexual Orientation, Gender Identity
Interventions
Critical Narrative Development
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 24 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Oct 22, 2026, 8:12 PM EDT
Completed Not applicable Interventional

Evaluating the Efficacy of the Parent Support Program

NCT04531761
View directory record Official record
Conditions
Prejudice, Gender Identity, Knowledge, Attitudes, Practice
Interventions
Parent Support Program
Behavioral
Lead sponsor
Palo Alto University
Other
Eligibility
18 Years and older
Enrollment
570 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 22, 2026, 8:12 PM EDT
Recruiting No phase listed Observational

Puberty, Testosterone, and Brain Development

NCT06670053
View directory record Official record
Conditions
Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
Interventions
Testosterone
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 20 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 22, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers

NCT03553992
View directory record Official record
Conditions
Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation, Tobacco Smoking, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco
Interventions
POP-6:, TSP-6:
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 22, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

TRANSLATE: Transgender and Gender Nonconforming Individuals' Access to Healthcare

NCT03808883
View directory record Official record
Conditions
Gender Identity
Interventions
TGNC Directed Advocacy Meetings, Facilitated Dialogues between TGNC Cohort and Healthcare Participants
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
14 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Oct 22, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre: Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre

NCT04515654
View directory record Official record
Conditions
Transgenderism, Stigma, Social
Interventions
IDEAS (Identity Evolution and Sharing) Performance
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Oct 22, 2026, 8:12 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

State of Hormones Impact Nociceptive Expression

NCT05787470
View directory record Official record
Conditions
Pain, Gender Identity
Interventions
Quantative sensory testing, Blood Draw
Behavioral · Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 22, 2026, 8:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women

NCT04066283
View directory record Official record
Conditions
Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation, Insulin Sensitivity, Blood Pressure, Lipid Disorder, Appetitive Behavior
Interventions
No intervention
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 8:12 PM EDT
Completed No phase listed Observational

Pubertal Blockade and Hormone Therapy in Transgender Youth

NCT03557268
View directory record Official record
Conditions
Gender Identity, Gender Dysphoria, Gender Identity Disorder in Adolescence and Adulthood
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
13 Years to 16 Years · Female only
Enrollment
19 participants
Timeline
2018 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 29, 2020 · Synced Oct 22, 2026, 8:12 PM EDT