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Showing 1–24 of 249 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Gingival Diseases Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model

NCT00779909
View directory record Official record
Conditions
Gingivitis
Interventions
vitamin D3, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 64 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2017 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks

NCT04050722
View directory record Official record
Conditions
Gingivitis
Interventions
Sensodyne Repair and Protect, Colgate Cavity Protection
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 9, 2026, 4:11 PM EDT
Terminated Not applicable Interventional

Does Chewing Gum After Elective Laparoscopic Colectomy Surgery Decrease Ileus?

NCT00632801
View directory record Official record
Conditions
Ileus
Interventions
chewing gum
Other
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 89 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Plaque Removal of a Novel Brushing Device

NCT05038293
View directory record Official record
Conditions
Dental Plaque
Interventions
Automated mouthpiece-based toothbrush, Manual toothbrush
Device
Lead sponsor
University of Washington
Other
Eligibility
5 Years to 17 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Sep 9, 2026, 4:11 PM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Topical 10% Povidone-Iodine in Preventing White Spots

NCT06616207
View directory record Official record
Conditions
White Spot Lesions, Gingival Inflammation and Bleeding
Interventions
Placebo, Povidone-iodine solution
Drug
Lead sponsor
University of Washington
Other
Eligibility
10 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Gum Chewing on Energy Intake and Expenditure

NCT01043471
View directory record Official record
Conditions
Obesity
Interventions
Chewing gum, Water
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 38 Years · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Results available

Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis

NCT02883244
View directory record Official record
Conditions
Gingivitis
Interventions
Soft-Picks Advanced, Floss
Device
Lead sponsor
Sunstar Americas
Industry
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Results available

A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen

NCT01419626
View directory record Official record
Conditions
Gingivitis
Interventions
Interdental cleaning device with water, Interdental cleaning device with essential-oil mouthrinse
Device
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites

NCT03570333
View directory record Official record
Conditions
Gingival Recession, Lack of Keratinized Gingiva (Disorder)
Interventions
progenitor potential of Gingival Mesenchymal cells
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Phase 4 Interventional Results available

Long-term Safety of Minocycline in Patients With Gum Disease

NCT00668746
View directory record Official record
Conditions
Periodontitis
Interventions
Minocycline HCl microspheres
Drug
Lead sponsor
OraPharma
Industry
Eligibility
25 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 11, 2011 · Synced Sep 9, 2026, 4:11 PM EDT
Recruiting Not applicable Interventional

Effects of Hard Gum Chewing on Facial Soft Tissue Morphology

NCT07726511
View directory record Official record
Conditions
Face
Interventions
Hard Gum Chewing
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
20 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

To Measure Pain Perception Following De-Epithelized Free Gingival Graft Harvesting

NCT03895476
View directory record Official record
Conditions
Gingival Recession, Palate; Wound
Interventions
palatal wound will be cover with collagen and sutures, palatal wound covered with platelet rich fibrin, palatal wound covered with a collagen sponge and cyanoacrylate, palatal wound covered with a stent
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Phase 2 Interventional Results available

Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP

NCT05258721
View directory record Official record
Conditions
Gingivitis, Periodontitis
Interventions
ClōSYS® Sensitive Fluoride Toothpaste, ClōSYS® Sensitive Rinse
Drug · Other
Lead sponsor
Rowpar Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 9, 2026, 4:11 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sonographic Imaging of Oral and Dental Anatomical Structures (A Pilot Study)

NCT03657589
View directory record Official record
Conditions
Ultrasound, Oral Mucosa, Gingival Recession, Alveolar Bone Loss
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 4, 2018 · Synced Sep 9, 2026, 4:11 PM EDT
Completed No phase listed Observational

A Clinical and Imaging Study to Evaluate a Novel Dentifrice

NCT02271815
View directory record Official record
Conditions
Gingivitis, Periodontitis, Dental Plaque
Interventions
Oral Hygiene
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional

Evaluating the Efficacy of a Gum Health Formulation on Teeth Whitening in Patients With Gingivitis and Periodontitis

NCT02906982
View directory record Official record
Conditions
Tooth Discoloration, Periodontal Diseases
Interventions
Gum health formulation in intra-oral device, Gum health formulation on toothbrush
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2016 · Synced Sep 9, 2026, 4:11 PM EDT
Not yet recruiting Not applicable Interventional

Free Soft Tissue Grafts FSTG) Using Autograft Palatal Donor Tissue vs. Xenograft Collagen Matrix (Zderm™)

NCT07713199
View directory record Official record
Conditions
Gingival Recession Localized Moderate, Dental Implant
Interventions
Zderm
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional

Dental Plaque Removal Study

NCT01559987
View directory record Official record
Conditions
Gingivitis, Gum Disease
Interventions
Manual Toothbrush only, MTB + Waterpik Ultra Water Flosser 'High', MTB + Floss (MTB+Floss)
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Chewing Gum for Weight Loss

NCT00971347
View directory record Official record
Conditions
Obesity, Overweight, Weight Loss
Interventions
Extra sugar-free chewing gum sticks, nutrition brochure
Other · Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 22, 2010 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional

Effect of Gum Arabic on Gastrointestinal Transit and Permeability

NCT03742076
View directory record Official record
Conditions
Diverticulitis
Interventions
High-dose prebiotic, Low-dose prebiotic, Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implant Placement With Simultaneous Gum Grafting

NCT01431144
View directory record Official record
Conditions
Edentulous
Interventions
connective tissue autograft, connective tissue allograft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Phase 4 Interventional

Pilot Study for Healing and Safety Outcomes in Gingival Recession

NCT04614350
View directory record Official record
Conditions
Gingival Recession
Interventions
Markman Biologics Microsurfaced ADM, AlloDerm
Biological
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Compare Anti-inflammatory Dentifrices

NCT00762528
View directory record Official record
Conditions
Gingivitis
Interventions
Triclosan/Copolymer/fluoride toothpaste, Sodium monofluorophosphate toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 9, 2015 · Synced Sep 9, 2026, 4:11 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.

NCT00966953
View directory record Official record
Conditions
Gingival Diseases
Interventions
Fluoride, Triclosan/Fluoride toothpaste, antibacterial plant extract
Drug · Other
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2009 · Synced Sep 9, 2026, 4:11 PM EDT