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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:22 PM EST

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Showing 145–168 of 253 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Gingival Diseases Clear all
Completed No phase listed Observational Accepts healthy volunteers

The Importance of Periostin in Periodontal Health and Disease

NCT01180920
View directory record Official record
Conditions
Periodontal Disease, Non-diseased Patients
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

To Compare Two Commonly Used Soft Tissue Grafting Techniques to Achieve Coronal Flap Advancement and Root Coverage

NCT03566108
View directory record Official record
Conditions
Gingival Recession
Interventions
VISTA, STA
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index

NCT05805865
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Toothpaste Tablet, Conventional Toothpaste
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for Visualization

NCT05932017
View directory record Official record
Conditions
Periodontal Diseases, Periodontal Pocket, Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss, Periodontal Bone Loss, Surgery
Interventions
Not listed
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Nov 15, 2026, 2:22 PM EST
Recruiting Not applicable Interventional

Oil Pulling Reduction

NCT07706647
View directory record Official record
Conditions
Good Health, Gingival Inflammation and Bleeding, Dental Plaque
Interventions
GuruNanda natural Oil Pulling oral rinse, TheraBreath Plaque Control Oral Rinse, GuruNanda water-based non-whitening mouthwash
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.

NCT06966492
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Stannous Fluoride Toothpaste (SnF)
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual Toothbrush

NCT07779564
View directory record Official record
Conditions
Gingivitis, Gingival Bleeding, Dental Plaque
Interventions
Electric Flosser, Manual Toothbrush
Device
Lead sponsor
Flaus, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Recruiting Not applicable Interventional

Effects of Hard Gum Chewing on Facial Soft Tissue Morphology

NCT07726511
View directory record Official record
Conditions
Face
Interventions
Hard Gum Chewing
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
20 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 1 Interventional

Treatment of Human Gingivitis With Amnion-derived Cellular Cytokine Solution (ACCS)

NCT02071199
View directory record Official record
Conditions
Gingivitis
Interventions
1X ACCS (Amnion-derived Cellular Cytokine Solution), Normal saline, 0.3X ACCS
Drug
Lead sponsor
Noveome Biotherapeutics, formerly Stemnion
Industry
Eligibility
18 Years to 70 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 29, 2016 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 2 Interventional Accepts healthy volunteers

Clinical Investigation to Assess the Efficacy of Manual Toothbrushes in the Reduction of Plaque and Gingivitis.

NCT06565897
View directory record Official record
Conditions
Plaque, Dental, Gingivitis
Interventions
Test regimen, Control regimen
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Completed No phase listed Observational Accepts healthy volunteers

A Follow-Up Survey of Oral Hygiene and Health Outcomes for Women Previously Enrolled in "OHMOM"

NCT02922010
View directory record Official record
Conditions
Gingivitis
Interventions
Not listed
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 19, 2017 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 4 Interventional Accepts healthy volunteers

A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice

NCT03936569
View directory record Official record
Conditions
Gingivitis
Interventions
Marketed Toothpaste, Marketed Cavity Protection Toothpaste
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional

Impact of Brief Motivational Interviewing on Periodontal Clinical Outcomes: a 3-year Post-trial Follow-up

NCT05336396
View directory record Official record
Conditions
Periodontal Diseases, Plaque Score, Bleeding on Probing, Gingival Index
Interventions
BMI
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

Pinhole Versus Tunnel for Soft Tissue Recession

NCT04513041
View directory record Official record
Conditions
Gingival Recession
Interventions
Pinhole surgical technique and tunnel technique in a split mouth design
Procedure
Lead sponsor
Mohanad Al-Sabbagh
Other
Eligibility
18 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Withdrawn Not applicable Interventional

The Effect of Gum Chewing on Postoperative Ileus

NCT00879294
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Motion sickness wristband, Chewing Gum
Device · Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
6 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Nov 15, 2026, 2:22 PM EST
Not yet recruiting Phase 1Phase 2 Interventional

Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus

NCT07877701
View directory record Official record
Conditions
Tinnitus, Chronic Subjective Tinnitus
Interventions
Nicotine polacrilex gum 4 mg, Placebo gum
Drug · Other
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 6, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 2 Interventional

Pilot Efficacy Study to Treat Gingivitis

NCT00391547
View directory record Official record
Conditions
Gingival Diseases
Interventions
Frio Oral Rinse
Drug
Lead sponsor
Biomedical Development Corporation
Industry
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 22, 2007 · Synced Nov 15, 2026, 2:22 PM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of Toothbrush Bristles

NCT07306026
View directory record Official record
Conditions
Gingivitis and Periodontal Diseases
Interventions
Toothbrush with tapered bristles, Toothbrush with end-rounded bristles
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Chewing Gum on a Computer Task and Liking Ratings of Ice Cream

NCT02198911
View directory record Official record
Conditions
Habituation
Interventions
NO GUM, MCC (Mint Chocolate Chip gum), C (Cinnamon gum)
Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implant Placement With Simultaneous Gum Grafting

NCT01431144
View directory record Official record
Conditions
Edentulous
Interventions
connective tissue autograft, connective tissue allograft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 1, 2017 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional

Dental Plaque Removal Study

NCT01559987
View directory record Official record
Conditions
Gingivitis, Gum Disease
Interventions
Manual Toothbrush only, MTB + Waterpik Ultra Water Flosser 'High', MTB + Floss (MTB+Floss)
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)

NCT05782348
View directory record Official record
Conditions
Adolescent Behavior, Dental Plaque, Gingivitis, Cognitive Change
Interventions
Cognitive behavioral intervention, Colgate smart toothbrush
Behavioral · Other
Lead sponsor
Howard University
Other
Eligibility
14 Years to 17 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

Oral Hygiene Intervention Pilot Study

NCT02668809
View directory record Official record
Conditions
Dental Caries, Gingivitis
Interventions
oral health assessment, Questionnaires, Clinical Exam, Microbiological sampling, Monitoring Adherence, Varnish application, Consent, Educational Program
Other
Lead sponsor
Leonardo Marchini
Other
Eligibility
21 Years to 120 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional

PD Study to Assess Phosphate Binding Characteristics of K2CG Chewing Gum

NCT01319578
View directory record Official record
Conditions
Hyperphosphatemia, Chronic Kidney Disease
Interventions
K2CG chewing gum
Other
Lead sponsor
Denver Nephrologists, P.C.
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 15, 2011 · Synced Nov 15, 2026, 2:22 PM EST