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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gum Disease Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Emdogain Minimally Invasive Surgical Technique

NCT02551770
View directory record Official record
Conditions
Periodontitis
Interventions
Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application
Procedure · Device
Lead sponsor
Institut Straumann AG
Industry
Eligibility
21 Years to 85 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Cullman, Alabama • Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 16, 2019 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pinhole Versus Tunnel for Soft Tissue Recession

NCT04513041
View directory record Official record
Conditions
Gingival Recession
Interventions
Pinhole surgical technique and tunnel technique in a split mouth design
Procedure
Lead sponsor
Mohanad Al-Sabbagh
Other
Eligibility
18 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of the ToothWave -12 Weeks Calculus Study

NCT04092075
View directory record Official record
Conditions
Gingivitis, Plaque, Calculus, Dental
Interventions
RF-utilizing powered toothbrush, Control placebo with no RF
Device
Lead sponsor
Home Skinovations Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Sep 28, 2026, 2:50 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis

NCT02710903
View directory record Official record
Conditions
Periodontitis
Interventions
Stent-induced biofilm overgrowth
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.

NCT07398846
View directory record Official record
Conditions
Plaque
Interventions
0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste, 0.022% Sodium Fluoride mouthwash
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 28, 2026, 2:50 PM EDT
Completed No phase listed Observational

Bacterial Arrangement on the Teeth

NCT01712672
View directory record Official record
Conditions
Dental Plaque, Oral Health, Periodontal Disease and Caries, Periodontal Disease
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Evaluate the Efficacy of a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation

NCT06933368
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Crest Cavity Protection Toothpaste, Experimental Mouthwash
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 28, 2026, 2:50 PM EDT
Completed No phase listed Observational

Periodontal Treatment Response in Type II Diabetic Patients

NCT01881074
View directory record Official record
Conditions
Type II Diabetes, Periodontal Disease
Interventions
Triclosan containing toothpaste, Non-triclosan containing toothpaste
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Sep 28, 2026, 2:50 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Dental Intervention Plan for Chronic Kidney Disease Patients Awaiting or With Kidney Transplant

NCT04020458
View directory record Official record
Conditions
Chronic Kidney Disease, Chronic Periodontitis, Generalized, Moderate
Interventions
dental intervention
Procedure
Lead sponsor
Augusta University
Other
Eligibility
21 Years to 75 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bone Regenerative Techniques in Endodontic Microsurgery

NCT04514991
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Foundation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

IFI16 is a Periodontitis Modulating Protein

NCT03513497
View directory record Official record
Conditions
Severe Periodontitis, Acute Inflammatory Response
Interventions
Customized acrylic mouthguard
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice

NCT06131021
View directory record Official record
Conditions
Periodontitis, Periodontal Diseases, Periodontal Pocket
Interventions
Amoxicillin, Metronidazole, Placebo
Drug · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
35 Years and older
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Gum Chewing on Energy Intake and Expenditure

NCT01043471
View directory record Official record
Conditions
Obesity
Interventions
Chewing gum, Water
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 38 Years · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Clinical Outcomes Between GentleWave® and Biolase®

NCT05555043
View directory record Official record
Conditions
Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
Interventions
Irrisafe ip, GentleWave System, Waterlase iPlus
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
14 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis

NCT07029438
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Mouthwash, Floss, Toothbrush, Toothpaste
Drug · Device
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional

Prevention of Ileus After Gynecologic Surgery Using Chewing Gum

NCT00831246
View directory record Official record
Conditions
Ileus
Interventions
chewing gum - Extra Winterfresh, Standard Post-Op Care
Other
Lead sponsor
Aultman Health Foundation
Other
Eligibility
18 Years and older · Female only
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 20, 2018 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Results available

Bone Level Tapered Multi-Center Study

NCT02569671
View directory record Official record
Conditions
Tooth Loss
Interventions
Straumann Bone Level Tapered Implant - Immediate Placement, Straumann Bone Level Tapered Implant - Delayed Placement
Device
Lead sponsor
Institut Straumann AG
Industry
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
3
States / cities
Los Angeles, California • Gainesville, Florida • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 28, 2026, 2:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarkers of Periodontal Disease Progression

NCT01489839
View directory record Official record
Conditions
Periodontal Disease
Interventions
Periodontal therapy
Other
Lead sponsor
The Forsyth Institute
Other
Eligibility
25 Years and older
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
5
States / cities
Edwardsville, Illinois • Cambridge, Massachusetts • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Sep 28, 2026, 2:50 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Use of a Non-Incised Minimally Invasive Flap Procedure in Conjunction With Emdogain® MI Compared to Traditional SRCP

NCT05964699
View directory record Official record
Conditions
Periodontitis, Attachment Loss, Periodontal
Interventions
Minimally invasive periodontal therapy with use of Emdogain, Minimally invasive periodontal therapy without the use of Emdogain
Procedure
Lead sponsor
Texas A&M University
Other
Eligibility
30 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Sep 28, 2026, 2:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stannous Fluoride and Gingivitis

NCT05326373
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous fluoride
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Sep 28, 2026, 2:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Periodontal Disease Prevention Study

NCT01584479
View directory record Official record
Conditions
Periodontitis
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
34 Years to 55 Years
Enrollment
5,117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Sep 28, 2026, 2:50 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Periodontal Disease and Preterm Birth

NCT00582374
View directory record Official record
Conditions
Periodontal Disease, Preterm Birth, Low Birth Weight
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
15 Years to 35 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Sep 28, 2026, 2:50 PM EDT
Completed No phase listed Observational

Facial Mucosal Level Determinants for Single Immediately Placed Implants Evaluated by Novel Ultrasonography

NCT03558282
View directory record Official record
Conditions
Gingival Recession
Interventions
Recession Observation, Crown Contour Observation
Other · Diagnostic Test
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Sep 28, 2026, 2:50 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Incidence of Bleeding on Probing as an Indicator of Peri-Implant Disease Progression

NCT06033859
View directory record Official record
Conditions
Peri-Implantitis, Bleeding of Subgingival Space
Interventions
Clinical measurements, Radiographic measurement, Dental prophylaxis or maintenance
Diagnostic Test · Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 80 Years
Enrollment
164 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 28, 2026, 2:50 PM EDT