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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gum Disease Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bone Augmentation Techniques in Extraction Sockets

NCT01836783
View directory record Official record
Conditions
Tooth Loss
Interventions
Amnion Allograft, Allograft
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 9, 2024 · Synced Jun 26, 2026, 4:13 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis

NCT02710903
View directory record Official record
Conditions
Periodontitis
Interventions
Stent-induced biofilm overgrowth
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Jun 26, 2026, 4:13 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Comparison of Inflammatory Mediators Surrounding Titanium or Zirconium Implant Abutments

NCT01870349
View directory record Official record
Conditions
Peri-implantitis
Interventions
Gingival Crevicular Fluid Sampling
Procedure
Lead sponsor
Christopher Barwacz
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Jun 26, 2026, 4:13 AM EDT
Withdrawn Not applicable Interventional

Efficacy of Methods to Treat Multiple Gingival Recession Defects

NCT03124329
View directory record Official record
Conditions
Gingival Recession
Interventions
Coronally Advanced Flap, Intrasulcular Tunneling, Vestibular Incision Subperiosteal Tunnel Access (VISTA), Leukocyte-Platelet Rich Fibrin (L-PRF)
Procedure · Biological · Device
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Post Tooth Extraction Healing Using Different Xenograft Materials

NCT03149172
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
Equimatrix®, Bio-Oss®, Endobon®
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 24, 2020 · Synced Jun 26, 2026, 4:13 AM EDT
Terminated No phase listed Observational

Study of Periodontitis and Blood Stream Infection in AML Patients Receiving Chemotherapy

NCT04858594
View directory record Official record
Conditions
Acute Myeloid Leukemia
Interventions
Planned Chemotherapy
Other
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 10, 2022 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ridge Preservation With Putty Allografts

NCT03956251
View directory record Official record
Conditions
Tooth Loss
Interventions
Combined Mineralized/Demineralized Putty Allograft, Demineralized Putty Allograft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mineralized and Partial Demineralized Dentin Graft Compared to FDBA

NCT05311735
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
Freeze-Dried Bone Allograft control, Mineralized Dentin Graft, Partial-Demineralized Dentin Graft
Procedure
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Jun 26, 2026, 4:13 AM EDT
Recruiting Phase 4 Interventional

Clinical Performance of Nobel N1 System

NCT07280260
View directory record Official record
Conditions
Tooth Loss, Dental Implant
Interventions
Nobel N1 implant
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional

Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes

NCT02914743
View directory record Official record
Conditions
Type II Diabetes, Periodontal Disease
Interventions
Motivational Interviewing, Dental cleaning
Behavioral · Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Oral Gut Liver Axis in Cirrhosis

NCT03030820
View directory record Official record
Conditions
Cirrhosis, Periodontitis, Gingivitis
Interventions
Dental Cleaning
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Phase 3 Interventional

Control of Periodontal Infections

NCT01098448
View directory record Official record
Conditions
Periodontitis
Interventions
scaling and root planing, local tetracycline, systemic metronidazole and amoxicillin, surgery, local antibiotics and systemic metronidazole and amoxicillin, local tetracycline and periodontal surgery, periodontal surgery and systemic metronidazole and amoxicillin, surgery, local tetracycline, systemic metronidazole and amoxicillin
Other · Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
20 Years and older
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2010 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Exploratory Study of Iocide Oral Rinse in a Diabetic Population

NCT00801164
View directory record Official record
Conditions
Diabetes Type 2, Periodontitis
Interventions
Frio Mouth Rinse Placebo, Frio Mouth Rinse
Drug
Lead sponsor
Biomedical Development Corporation
Industry
Eligibility
35 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Jun 26, 2026, 4:13 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Ridge Preservation Comparing Simultaneous vs. Delayed Grafting

NCT03580798
View directory record Official record
Conditions
Tooth Loss
Interventions
Delayed graft, Simultaneous graft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria Saliva and Bioaerosol Contamination Phase 2

NCT04717063
View directory record Official record
Conditions
Healthy
Interventions
Peroxyl Oral Product, Placebo
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2021 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ridge Preservation Following Tooth Extraction Using Porcine and Bovine Xenograft Materials

NCT02802319
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
Porcine Xenograft (Zcore), Bovine Xenograft (Bio-Oss)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Jun 26, 2026, 4:13 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

An Observational Study of the T3 Pro Dental Implant System

NCT05498662
View directory record Official record
Conditions
Tooth Loss
Interventions
T3 Pro dental implant system
Device
Lead sponsor
ZimVie
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
2
States / cities
New Orleans, Louisiana • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 26, 2026, 4:13 AM EDT
Not listed Not applicable Interventional

Clinical Trial of PeriZone PerioPatch in Subjects With Chronic Periodontitis

NCT01808703
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
PeriZone PerioPatch, Scaling and root planing alone
Device · Procedure
Lead sponsor
MIS Implant Technologies, Ltd
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 10, 2013 · Synced Jun 26, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

4-day Plaque Accumulation Model Evaluating Compound Containing Gum

NCT06984744
View directory record Official record
Conditions
Dental Plaque Accumulation
Interventions
MIIP-E2 containing gum, placebo gum without MIIP-E2
Device
Lead sponsor
Lactea Therapeutics, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Chewing Gum on a Computer Task and Liking Ratings of Ice Cream

NCT02198911
View directory record Official record
Conditions
Habituation
Interventions
NO GUM, MCC (Mint Chocolate Chip gum), C (Cinnamon gum)
Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Thick vs. Thin Acellular Dermal Matrix (ADM)

NCT03392038
View directory record Official record
Conditions
Gingival Recession
Interventions
Thin ADM, Thick ADM
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Jun 26, 2026, 4:13 AM EDT
Completed Not applicable Interventional

Platelet Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain

NCT01530126
View directory record Official record
Conditions
Periodontitis
Interventions
B-TCP + 0.3 mg/ml rhPDGF-BB in buffer, B-TCP + 1.0 mg/ml rhPDGF-BB in buffer, B-TCP +buffer
Biological
Lead sponsor
University of Michigan
Other
Eligibility
25 Years to 75 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2007
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Jun 26, 2026, 4:13 AM EDT
Active, not recruiting No phase listed Observational

Effectiveness of Scaling and Root Planing in Deeper Pockets

NCT06890689
View directory record Official record
Conditions
Periodontal Disease, Periodontitis
Interventions
Scaling and root planing
Procedure
Lead sponsor
Texas A&M University
Other
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Jun 26, 2026, 4:13 AM EDT