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Showing 1–24 of 654 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gut -Microbiota Clear all
Active, not recruiting Not applicable Interventional Results available

Early Protein Supplementation in Extremely Preterm Infants Fed Human Milk

NCT04325308
View directory record Official record
Conditions
Prematurity; Extreme, Feeding Disorder Neonatal, Breast Milk Expression, Growth Failure, Microbial Colonization
Interventions
Protein-enriched human milk diet, Usual human milk diet
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Day to 4 Days
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 2, 2026, 11:04 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults

NCT05387876
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Vitamin D intervention, Placebo intervention
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 79 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated May 23, 2022 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Phase 2 Interventional Results available

Effects of the Probiotic Visbiome Extra Strength on Gut Microbiome & Immune Activation Markers

NCT02706717
View directory record Official record
Conditions
HIV-1 Infection
Interventions
Visbiome Extra Strength, Placebo
Drug
Lead sponsor
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Network
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
24
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2020 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Acetate and Age-associated Arterial Dysfunction

NCT05424263
View directory record Official record
Conditions
Aging, Vascular Stiffness, Vascular Dilation
Interventions
Calcium Acetate Oral Solution, Calcium Carbonate Oral Suspension
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Resistant Maltodextrin Supplementation: Gastrointestinal Health

NCT02733263
View directory record Official record
Conditions
Healthy
Interventions
15 g RMD, 25 g RMD, 0 g RMD
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 1, 2018 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ergogenic Properties of Magnesium Supplementation

NCT05282693
View directory record Official record
Conditions
Exercise Performance, Gut -Microbiota, Mitochondrial Function
Interventions
ReMag, Placebo
Dietary Supplement
Lead sponsor
Christopher Bell
Other
Eligibility
18 Years to 40 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 2, 2026, 11:04 AM EDT
Completed No phase listed Observational

Environmental Health Effects on Your Physiology

NCT03986814
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 25 Years
Enrollment
92 participants
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Small Bowel Microbiota Characterization in Healthy Individuals Before and After Consumption of a Western Diet

NCT03266536
View directory record Official record
Conditions
Small Intestine Bacteria
Interventions
Western diet
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional

Effect of Daily Consumption of Glycomacropeptide on Gut Microbiome and Blood Functional Proteome of Subjects With Irritable Bowel Syndrome

NCT05482464
View directory record Official record
Conditions
Inflammatory Bowel Syndrome
Interventions
Casein glycomacropeptide (CGMP)
Dietary Supplement
Lead sponsor
Oregon State University
Other
Eligibility
18 Years to 30 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Sep 2, 2026, 11:04 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Early Avocado Exposure on Development and the Gut Microbiome in American Hispanic Infants

NCT06876935
View directory record Official record
Conditions
Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infant Growth
Interventions
Daily avocado
Other
Lead sponsor
Arizona State University
Other
Eligibility
3 Months to 6 Months
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Sep 2, 2026, 11:04 AM EDT
Withdrawn Phase 2 Interventional

Healthy-donor Microbiome MTP-101-C in Steroid Relapse/Refractory Immune-related Cutaneous Adverse Events (irCAEs) and Immune-mediated Colitis (IMC)

NCT06499896
View directory record Official record
Conditions
Immune-mediated Colitis (IMC), Immune-related Dermatitis
Interventions
MTP-101-C
Biological
Lead sponsor
Diwakar Davar
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 2, 2026, 11:04 AM EDT
Recruiting No phase listed Observational

Evaluating the Association Among Changes in Gut Microbiome, Fatigue, and Chemotherapy-Induced Nausea in Early Stage Breast Cancer

NCT05417867
View directory record Official record
Conditions
Chemotherapy-Related Nausea and/or Vomiting, Early Stage Breast Carcinoma, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Interventions
Biospecimen Collection, Questionnaire Administration
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
5
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Albert Lea, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Dietary Fructose on Gut Microbiota and Fecal Metabolites in Obese Men and Postmenopausal Women: A Pilot Study

NCT03339245
View directory record Official record
Conditions
Non-Alcoholic Fatty Liver Disease, Obesity
Interventions
Fructose Solution (75 Grams), Glucose Solution (75 grams)
Other
Lead sponsor
Rockefeller University
Other
Eligibility
45 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Traumatic Brain Injury and the Gut Microbiome

NCT04949607
View directory record Official record
Conditions
Brain Injury, Chronic, Brain Injuries, Traumatic
Interventions
Inulin fructooligosaccharide
Dietary Supplement
Lead sponsor
Centre for Neuro Skills
Industry
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Bakersfield, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Sep 2, 2026, 11:04 AM EDT
Not listed No phase listed Observational

Composition and Collection Feasibility of Gut Microbiota in Children With and Without Obesity

NCT03149601
View directory record Official record
Conditions
Childhood Obesity
Interventions
Not listed
Lead sponsor
University of Illinois College of Medicine at Peoria
Other
Eligibility
5 Years to 12 Years
Enrollment
150 participants
Timeline
2017 – 2019
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Sep 2, 2026, 11:04 AM EDT
Withdrawn Phase 2 Interventional

Fecal Microbiota Transplantation For The Treatment Of Gastro-Intestinal Acute GVHD

NCT04059757
View directory record Official record
Conditions
Gastro-Intestinal Acute Graft Versus Host Disease (GI-aGVHD)
Interventions
Fecal Microbiota Transplantation (FMT)
Biological
Lead sponsor
Leland Metheny
Other
Eligibility
19 Years to 74 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 6, 2022 · Synced Sep 2, 2026, 11:04 AM EDT
Not yet recruiting Not applicable Interventional

Isocaloric Navy-Bean Substitution in Adults With MASLD

NCT07730853
View directory record Official record
Conditions
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Liver Fibrosis, Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Interventions
Dietary Supplement/Behavioral: Navy Bean-Rich Diet, Habitual Diet (Control)
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Human Milk and Infant Intestinal Microbiome Study

NCT03181269
View directory record Official record
Conditions
Breast Feeding, Human Microbiome
Interventions
Intervention education, Placebo Education
Other
Lead sponsor
University of Virginia
Other
Eligibility
Not listed
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 20, 2018 · Synced Sep 2, 2026, 11:04 AM EDT
Active, not recruiting Not applicable Interventional

Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors

NCT04088708
View directory record Official record
Conditions
Breast Cancer, Gut Microbiome, Exercise, Fatigue
Interventions
Aerobic Exercise Training, Attention Control
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 74 Years · Female only
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Sep 2, 2026, 11:04 AM EDT
Recruiting Not applicable Interventional

Dietary Wild Blueberries and Joint Health

NCT06828159
View directory record Official record
Conditions
Gut -Microbiota, Inflammation Biomarkers, Pain Assessment, Joint Pain
Interventions
Wild blueberry, Placebo
Dietary Supplement
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
40 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

What's Hopping? Cricket Protein and Human Gut Microbiota

NCT03383341
View directory record Official record
Conditions
Healthy
Interventions
Cricket Protein Powder, Placebo control
Dietary Supplement · Other
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Sep 2, 2026, 11:04 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human

NCT04267705
View directory record Official record
Conditions
Insulin Sensitivity, Overweight or Obesity, Inflammatory Response
Interventions
Control, Black bean, Chickpea
Other
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 2, 2026, 11:04 AM EDT
Completed Not applicable Interventional

Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children

NCT03414775
View directory record Official record
Conditions
Critical Illness, Dysbiosis, Pediatric ALL
Interventions
Nourish, Pediasure
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
1 Year to 17 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 2, 2026, 11:04 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Developmental Impacts of Microplastics Exposure in Early Life

NCT06107933
View directory record Official record
Conditions
Infant Development, Breast Feeding, Environmental Exposure
Interventions
Observational only
Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 2, 2026, 11:04 AM EDT