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Showing 1–24 of 70 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gut Permeability Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Effera Human Lactoferrin at One Dose Compared to Placebo on Gut Permeability

NCT07035964
View directory record Official record
Conditions
Gut Permeability, Gut Health
Interventions
human lactoferrin, Placebo
Dietary Supplement
Lead sponsor
Helaina Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of an Encapsulated Calcium Butyrate Dietary Supplement on Gut Health

NCT06397482
View directory record Official record
Conditions
Healthy, Gastrointestinal Discomfort
Interventions
Encapsulated Calcium Butyrate
Dietary Supplement
Lead sponsor
Kemin Foods LC
Industry
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Phase 3 Interventional

Effect of VSL#3 on Intestinal Permeability in Pediatric Crohn's Disease

NCT00944736
View directory record Official record
Conditions
Crohn's Disease
Interventions
VSL#3, Placebo
Dietary Supplement
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
11 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 9, 2014 · Synced Jul 25, 2026, 9:21 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe

NCT04565821
View directory record Official record
Conditions
Inflammatory Disease, Permeability; Increased, Crohn Disease, Inflammatory Bowel Diseases, Environmental Enteropathy
Interventions
IPD Probe via TNIT
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Phase 1Phase 2 Interventional

A Study of Glutamine to Treat Intestinal Permeability in Functional Dyspepsia

NCT05655819
View directory record Official record
Conditions
Functional Dyspepsia
Interventions
Glutamine, Placebo
Drug
Lead sponsor
David J. Cangemi
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jul 25, 2026, 9:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Gut, Immune, and Vascular Health in Metabolically Healthy Obesity

NCT07559227
View directory record Official record
Conditions
Metabolically Healthy Obesity
Interventions
Inulin Supplementation, Maltodextrin (Placebo), High-fat meal
Dietary Supplement · Other
Lead sponsor
Ball State University
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jul 25, 2026, 9:21 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Standardizing Method and Development of Normal Values to Measure Human Small Intestinal and Colonic Permeability

NCT04262310
View directory record Official record
Conditions
Healthy
Interventions
Small Bowel and Colonic Permeability Test
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

A Study of Perturbation of Human Small Intestinal Colonic Permeability

NCT06033222
View directory record Official record
Conditions
Healthy
Interventions
Ricinoleic Acid 750 mg, Ricinoleic Acid 1500 mg, Ricinoleic Acid 3000 mg, Placebo
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Phase 2 Interventional Results available

A Study of the Gut Barrier and Blood Vessel Inflammation in Individuals With and Without HIV

NCT02431325
View directory record Official record
Conditions
HIV
Interventions
Teduglutide, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2023 · Synced Jul 25, 2026, 9:21 AM EDT
Not yet recruiting Not applicable Interventional

The Effects of Mango on Gut Health Markers

NCT07559604
View directory record Official record
Conditions
Gut Health, LBP, Short Chain Fatty Acids, sCD14
Interventions
Mango
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
40 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Phase 1 Interventional Results available

Intestinal Permeability in Preterm Infants

NCT01756040
View directory record Official record
Conditions
Prematurity, Intestinal Permeability
Interventions
Lactulose -rhamnose solution
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
Up to 4 Days
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vitamin D and Adipose Tissue Inflammation

NCT01477034
View directory record Official record
Conditions
Vitamin D Deficiency, Obesity, Type 2 Diabetes Mellitus, Intestinal Permeability
Interventions
Vitamin D3
Dietary Supplement
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 3, 2014 · Synced Jul 25, 2026, 9:21 AM EDT
Active, not recruiting Not applicable Interventional Results available

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

NCT05318183
View directory record Official record
Conditions
PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
Interventions
Whole Wheat Bread, White Bread (control)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 25, 2026, 9:21 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Intestinal Permeability in Children/Adolescents With Functional Dyspepsia

NCT00363597
View directory record Official record
Conditions
Functional Dyspepsia
Interventions
Not listed
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
8 Years to 17 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 18, 2020 · Synced Jul 25, 2026, 9:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Western Diet on Cardiometabolic and Immune Function

NCT06528977
View directory record Official record
Conditions
Aging, Diet, Healthy
Interventions
Western Diet
Other
Lead sponsor
University of Delaware
Other
Eligibility
50 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Not applicable Interventional

Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome

NCT01094041
View directory record Official record
Conditions
Diarrhea, Diarrhea Predominant Irritable Bowel Syndrome
Interventions
Gluten free diet, Gluten rich diet
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 9, 2013 · Synced Jul 25, 2026, 9:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents

NCT07125001
View directory record Official record
Conditions
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
Interventions
Ataulfo mango
Other
Lead sponsor
University of California, Davis
Other
Eligibility
12 Years to 19 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jul 25, 2026, 9:21 AM EDT
Not listed Not applicable Interventional

Intestinal Inflammation and Carbohydrate Digestion in Autistic Children

NCT00227487
View directory record Official record
Conditions
Autism, Inflammation
Interventions
Stool collection, Administration of carbohydrate solution during clinically indicated endoscopy, Questionnaires
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Months to 17 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts • Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Not applicable Interventional

A Study of Hemp Hull WFI for IBS Diarrhea

NCT06028035
View directory record Official record
Conditions
Irritable Bowel Syndrome-bile Acid Diarrhea
Interventions
BB01
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Phase 1 Interventional

Intestinal Permeability in Response to Treatment in Eosinophilic Esophagitis Patients

NCT01641913
View directory record Official record
Conditions
Eosinophilic Esophagitis
Interventions
Absorbable sugars
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 23, 2014 · Synced Jul 25, 2026, 9:21 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Microbiome in Colorectal Cancer Onset and Progression

NCT05368688
View directory record Official record
Conditions
Colorectal Cancer, Tumor, CRC, GI Cancer, Gastrointestinal Cancer
Interventions
Not listed
Lead sponsor
Viome
Industry
Eligibility
50 Years to 80 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Dec 26, 2022 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Phase 4 Interventional Results available

rHGH and Intestinal Permeability in Intestinal Failure

NCT01380366
View directory record Official record
Conditions
Short Bowel Syndrome
Interventions
Somatropin, Seven Day Food Diary, Blood Tests (standard of care), Fasting, Sugar Permeability Test, Urine Collection
Drug · Procedure · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Jul 25, 2026, 9:21 AM EDT
Completed No phase listed Observational

Intracellular Tight Junction Permeability in Schizophrenia: Focus on Zonulin

NCT01558570
View directory record Official record
Conditions
Schizophrenia, Celiac Disease
Interventions
Blood Draw
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Jul 25, 2026, 9:21 AM EDT
Completed Early Phase 1 Interventional

Effects of a Western-type Diet on Colorectal Inflammation

NCT00866450
View directory record Official record
Conditions
Colorectal Inflammation
Interventions
Western style diet (high fat and low in calcium), Prudent-style diet (low fat and high in calcium)
Dietary Supplement
Lead sponsor
Rockefeller University
Other
Eligibility
50 Years to 72 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2012 · Synced Jul 25, 2026, 9:21 AM EDT