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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:23 AM EST

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Showing 1–24 of 72 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Gut Permeability Clear all

Conditions: Inflammatory Disease, Permeability; Increased, Crohn Disease, Inflammatory Bowel Diseases, Environmental Enteropathy
Interventions: IPD Probe via TNIT; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Prediabetes
Interventions: Cocoa, Placebo; Other
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 40 Years to 75 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Blacksburg, Virginia

Conditions: Colorectal Inflammation
Interventions: Western style diet (high fat and low in calcium), Prudent-style diet (low fat and high in calcium); Dietary Supplement
Lead sponsor: Rockefeller University; Other
Eligibility: 50 Years to 72 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Low-grade Chronic Inflammation, Intestinal Permeability, Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
Interventions: Fructose-sweetened beverages, Glucose-sweetened beverages, High-fructose corn syrup-sweetened beverages; Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Gastrointestinal Tract
Interventions: MRE; Other
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 18 Years to 62 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Irritable Bowel Syndrome
Interventions: Not listed
Lead sponsor: Metabolic Solutions Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Diarrhea, Diarrhea Predominant Irritable Bowel Syndrome
Interventions: Gluten free diet, Gluten rich diet; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: HIV
Interventions: Teduglutide, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 21 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Autism
Interventions: Gluten and dry milk, Placebo; Dietary Supplement
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 3 Years to 12 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Short Bowel Syndrome
Interventions: Somatropin, Seven Day Food Diary, Blood Tests (standard of care), Fasting, Sugar Permeability Test, Urine Collection; Drug · Procedure · Other
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2015
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Impaired Small Intestinal Permeability
Interventions: 12C mannitol, Indomethacin, 13C mannitol, Lactulose; Dietary Supplement · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
Interventions: Whole Wheat Bread, White Bread (control); Other
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Irritable Bowel Syndrome-bile Acid Diarrhea
Interventions: BB01; Dietary Supplement
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Intestinal Barrier Function
Interventions: Probiotic, Placebo; Dietary Supplement
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 50 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Intestinal Permeability
Interventions: plant derived phenolics, Microcrystaline cellulose (MCC); Dietary Supplement · Other
Lead sponsor: Brightseed; Industry
Eligibility: 30 Years to 69 Years
Enrollment: 126 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Addison, Illinois

Conditions: Alcoholic Liver Disease
Interventions: Sugar test, Aspirin Challenge; Other · Drug
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 195 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2015
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Normal-weight Obesity, Obesity
Interventions: Exercise tests (VO2 max test and 45-minute exercise session at 65% VO2 max); Other
Lead sponsor: Oklahoma State University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Stillwater, Oklahoma

Conditions: Inflammation, Vaccine, Intestinal Permeability, Typhoid Fever
Interventions: Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine; Dietary Supplement · Biological
Lead sponsor: USDA, Western Human Nutrition Research Center; Federal
Eligibility: 18 Years to 59 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Davis, California

Conditions: Gastrointestinal Injury, Acute Mountain Sickness
Interventions: FP, Placebo, High altitude, Sea level; Dietary Supplement · Other
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 17 Years to 39 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Intestinal Diseases, Irritable Bowel Syndrome, Constipation
Interventions: Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy; Diagnostic Test · Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Gut Permeability, Gut Health
Interventions: human lactoferrin, Placebo; Dietary Supplement
Lead sponsor: Helaina Inc.; Industry
Eligibility: 18 Years to 40 Years
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Addison, Illinois

Conditions: Crohn Disease
Interventions: Lactulose/Rhamnose solution, MB-102; Drug
Lead sponsor: MediBeacon; Industry
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Crohn's Disease
Interventions: VSL#3, Placebo; Dietary Supplement
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 11 Years to 17 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Inflammatory Bowel Diseases
Interventions: Stool collection, Biopsy collection; Diagnostic Test
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: Up to 65 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: The Bronx, New York

Search by objective public record fields.

Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe

Cocoa and Metabolic Health in Prediabetes

Effects of a Western-type Diet on Colorectal Inflammation

Diet and Systemic Inflammation

MRE Consumption and Gut Health

Sucrose Breath Test to Determine Intestinal Permeability in IBS

Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome

A Study of the Gut Barrier and Blood Vessel Inflammation in Individuals With and Without HIV

Pilot Study of Diet and Behavior in Children With Autism

rHGH and Intestinal Permeability in Intestinal Failure

Performance of 13C Mannitol for in Vivo Measurement of Small Intestinal Permeability

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

A Study of Hemp Hull WFI for IBS Diarrhea

The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults

Dietary Supplementation on Gastrointestinal Barrier Function

Alcohol, Gut Leakiness, & Liver Disease

Exercise-Induced Gut Permeability in Normal-weight Obesity

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude

Biomarkers for Intestinal Permeability in Patients With Constipation

Effects of Effera Human Lactoferrin at One Dose Compared to Placebo on Gut Permeability

Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability

Effect of VSL#3 on Intestinal Permeability in Pediatric Crohn's Disease

The Role of the Pregnane X Receptor (PXR) in Indole Signaling and Intestinal Permeability in Inflammatory Bowel Disease