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Showing 1–24 of 87 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: HIV, Depression Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

NCT06627764
View directory record Official record
Conditions
Substance Abuse, Intimate Partner Violence (IPV), HIV Infections, Depression, Anxiety
Interventions
SER Familia
Behavioral
Lead sponsor
Duke University
Other
Eligibility
12 Years to 100 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Results available

Treating Chronic Pain and Depression in HIV+ Patients in Primary Care Settings

NCT01735708
View directory record Official record
Conditions
Pain Interference, Depression, Antiretroviral Adherence
Interventions
HIVPASS, Health Education
Behavioral · Other
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional

Effectiveness of Nurse-delivered Care for Adherence/Mood in HIV in South Africa

NCT02696824
View directory record Official record
Conditions
Immunodeficiency Virus, Human, Depressive Symptoms
Interventions
Cognitive Behavioral Therapy for Adherence and Depression
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Miami, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 18, 2021 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Results available

Depression Therapy to Improve Cardiovascular Risk in HIV

NCT02309372
View directory record Official record
Conditions
Depression, HIV
Interventions
Beating the Blues
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Results available

Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use

NCT03864653
View directory record Official record
Conditions
HIV/AIDS, Methamphetamine Abuse, Depression
Interventions
MoodGym
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
Male only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2020 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects

NCT03581305
View directory record Official record
Conditions
Depression, HIV Infections, HIV-Associated Cognitive Motor Complex
Interventions
18F-FDOPA, 11C-DASB
Drug
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 70 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Jun 10, 2026, 1:27 PM EDT
Recruiting Not applicable Interventional

Implementing Depression and Adherence Treatment

NCT07032363
View directory record Official record
Conditions
Depression, HIV, Adherence, Treatment, AIDS
Interventions
Core Implementation Strategies, Enhanced Implementation Strategies
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
Miami, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Results available

Support for Perinatal Adherence and Depression

NCT03069417
View directory record Official record
Conditions
Human Immunodeficiency Virus, Depression
Interventions
Integrating Nuanced Support for Perinatal adherence and Depression
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Jun 10, 2026, 1:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Stress and Pain in People Living With HIV

NCT06784908
View directory record Official record
Conditions
HIV, Depression, Cannabis Use Disorder, Stress, Pain
Interventions
Yale Pain Stress Task (YPST)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 68 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Jun 10, 2026, 1:27 PM EDT
Terminated Phase 1 Interventional

Cognitive Behavioral Therapy to Help HIV Infected Adults With Depression to Adhere to Antiretroviral Therapy

NCT00509340
View directory record Official record
Conditions
Depression, HIV Infection
Interventions
Cognitive behavioral therapy (CBT)
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Jun 20, 2013 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effectiveness of the Screen, Test, Immunize, Reduce Risk, and Refer (STIRR) Intervention for People With Both a Mental and Substance Abuse Disorder

NCT00316303
View directory record Official record
Conditions
HIV Infections, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depression, Substance Abuse
Interventions
Twinrix, Enhanced treatment as usual
Drug · Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 21, 2013 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Phase 1 Interventional Results available

Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)

NCT00285584
View directory record Official record
Conditions
HIV Infections, Depression
Interventions
Bupropion, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older · Male only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Results available

Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1

NCT00218634
View directory record Official record
Conditions
Adherence, Depression, Heroin Dependence, Methadone, Motivational Interviewing, Substance-Related Disorders
Interventions
CBT-AD, ETAU
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 1, 2018 · Synced Jun 10, 2026, 1:27 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Transgender Cohort Study of Gender Affirmation and HIV-related Health

NCT03595956
View directory record Official record
Conditions
HIV/AIDS, STI, Gender Dysphoria, Transsexualism, Gender Identity, Depression, Anxiety
Interventions
Medical gender affirmation
Other
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older
Enrollment
4,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2020 · Synced Jun 10, 2026, 1:27 PM EDT
Completed No phase listed Observational

Psychosocial Correlates and Coping Strategies Associated With Long-Term Survival of HIV-Infected Children

NCT00001435
View directory record Official record
Conditions
Acquired Immunodeficiency Syndrome, Depressive Disorder, HIV Infections
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow

NCT00634608
View directory record Official record
Conditions
Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy, Bursitis, Depression, Anxiety, Diabetes Mellitus, Esophageal Reflux, HIV Infections, Hyperlipidemia, Hypertension, Insomnia, Irritable Bowel Syndrome, Obesity, Osteoporosis (Senile), Shoulder Pain, Sinusitis, Symptomatic Menopause, Urinary Incontinence, Urinary Tract Infection, Vaginitis
Interventions
Health Information Prescription
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Jun 10, 2026, 1:27 PM EDT
Completed No phase listed Observational

Project BEST: Buprenorphine Entry Into Substance Abuse Treatment

NCT02583243
View directory record Official record
Conditions
Opioid-related Disorders, HIV Infections, Hepatitis C, Chronic, Depression
Interventions
MET/CBT based individualized counseling, Buprenorphine
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Phase 3 Interventional

Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users

NCT00183768
View directory record Official record
Conditions
HIV Infections, Depression, Substance-Related Disorders
Interventions
Cognitive Behavioral Therapy, Psychopharmacology
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 21, 2013 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional

Behavioral Depression Treatment for African American HIV-infected Substance Users

NCT01351454
View directory record Official record
Conditions
Depression, Substance Use
Interventions
ACT HEALTHY, Nondirective Therapy (NDT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia • College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional

Optimizing Resilience and Coping in HIV Via Internet Delivery

NCT01997008
View directory record Official record
Conditions
HIV Disease, Depression, Affect, Psychological Stress
Interventions
Intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2020 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Results available

IMPAACT 2002: Cognitive Behavioral Therapy and Medication Management for Treatment of Depression in US Youth With HIV

NCT02939131
View directory record Official record
Conditions
HIV, Depression
Interventions
Health and Wellness Combined Cognitive Behavioral Therapy and a Medication Management Algorithm, Enhanced Standard of Care
Behavioral
Lead sponsor
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Network
Eligibility
12 Years to 24 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
13
States / cities
Alhambra, California • La Jolla, California • Los Angeles, California + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ADHOC Mindfulness-Based Research

NCT04580082
View directory record Official record
Conditions
Hiv, Loneliness, Depression, Anxiety
Interventions
Mindfulness lessons
Behavioral
Lead sponsor
Mazonson & Santas Inc.
Industry
Eligibility
50 Years and older
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Larkspur, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Jun 10, 2026, 1:27 PM EDT
Completed Phase 4 Interventional Results available

SSRI Effects on Depression and Immunity in HIV/AIDS

NCT02620150
View directory record Official record
Conditions
Depression, HIV, AIDS
Interventions
Escitalopram, Placebo
Drug · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Jun 10, 2026, 1:27 PM EDT
Withdrawn Not applicable Interventional

Writing to Alleviate Violence Exposure for Transgender Women (WAVE-TW)

NCT04305977
View directory record Official record
Conditions
PTSD, Depression, Virus, Human Immunodeficiency
Interventions
WAVE-TW
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced Jun 10, 2026, 1:27 PM EDT