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Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hakim Syndrome Clear all
Recruiting No phase listed Observational

Diagnostic Accuracy of ShuntCheck Compared to Radionuclide Shunt: Patency in Patients With Normal Pressure Hydrocephalus

NCT04309487
View directory record Official record
Conditions
Hydrocephalus, Normal Pressure
Interventions
ShuntCheck
Diagnostic Test
Lead sponsor
University of South Florida
Other
Eligibility
40 Years and older
Enrollment
20 participants
Timeline
2020 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jun 26, 2026, 4:10 AM EDT
Active, not recruiting Not applicable Interventional

Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

NCT06498960
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
CereVasc eShunt System, VP Shunt
Device
Lead sponsor
CereVasc Inc
Industry
Eligibility
60 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
29
States / cities
Los Angeles, California • New Haven, Connecticut • Jacksonville, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jun 26, 2026, 4:10 AM EDT
Completed No phase listed Observational

Normal Pressure Hydrocephalus (NPH) Registry

NCT00233701
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Not listed
Lead sponsor
Codman & Shurtleff
Industry
Eligibility
18 Years and older
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
28
States / cities
Phoenix, Arizona • Los Angeles, California • Boulder, Colorado + 25 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2010 · Synced Jun 26, 2026, 4:10 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland

NCT06426004
View directory record Official record
Conditions
Normal Pressure Hydrocephalus, Hakim Syndrome
Interventions
patients will receive NPH education, primary care physicians (PCPs) will receive professional NPH education, A community health worker will assist PCP
Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
65 Years and older
Enrollment
660 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2032
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jun 26, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials

NCT07494812
View directory record Official record
Conditions
NPH (Normal Pressure Hydrocephalus)
Interventions
Intellidrop Automated CSF Drainage System
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
60 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jun 26, 2026, 4:10 AM EDT
Recruiting No phase listed Observational

Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Normal Pressure Hydrocephalus

NCT04011566
View directory record Official record
Conditions
Hydrocephalus, Normal Pressure
Interventions
ShuntCheck
Diagnostic Test
Lead sponsor
University of South Florida
Other
Eligibility
40 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jun 26, 2026, 4:10 AM EDT
Terminated No phase listed Observational

ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus

NCT00946127
View directory record Official record
Conditions
Hydrocephalus
Interventions
Ventriculoperitoneal Shunt Placement, Endoscopic Third Ventriculostomy(ETV)
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 2, 2012 · Synced Jun 26, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

A Randomized Cross-over Study for Normal Pressure Hydrocephalus

NCT01798641
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
MIETHKE proGAV® / MIETHKE proSA®
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years to 85 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
5
States / cities
Baltimore, Maryland • Detroit, Michigan • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2018 · Synced Jun 26, 2026, 4:10 AM EDT
Completed Phase 3 Interventional Results available

A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.

NCT00196196
View directory record Official record
Conditions
Hydrocephalus, Normal Pressure Hydrocephalus
Interventions
Codman VPV System
Device
Lead sponsor
Codman & Shurtleff
Industry
Eligibility
Not listed
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
8
States / cities
Phoenix, Arizona • Orlando, Florida • Boston, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated May 27, 2012 · Synced Jun 26, 2026, 4:10 AM EDT
Withdrawn Phase 4 Interventional

ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients

NCT00793416
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Shunt flow detection
Device
Lead sponsor
NeuroDx Development
Industry
Eligibility
35 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 28, 2013 · Synced Jun 26, 2026, 4:10 AM EDT
Active, not recruiting Not applicable Interventional

US Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

NCT05232838
View directory record Official record
Conditions
Hydrocephalus, Normal Pressure, Hydrocephalus
Interventions
eShunt Implant
Device
Lead sponsor
CereVasc Inc
Industry
Eligibility
65 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
11
States / cities
New Haven, Connecticut • Jacksonville, Florida • Kansas City, Kansas + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Jun 26, 2026, 4:10 AM EDT
Terminated Not applicable Interventional Results available

Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus

NCT00613886
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Programmable Shunt Insertion (Codman, Medtronic), Assessments in physical therapy, occupational therapy, and speech therapy
Device · Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Jun 26, 2026, 4:10 AM EDT
Active, not recruiting Not applicable Interventional

Efficacy in iNPH Shunting (PENS) Trial

NCT05081128
View directory record Official record
Conditions
Idiopathic Normal Pressure Hydrocephalus (INPH)
Interventions
programmable CSF shunt valve
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
14
States / cities
Davis, California • Los Angeles, California • Santa Monica, California + 10 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jun 26, 2026, 4:10 AM EDT
Terminated No phase listed Observational

CPT-3 in Normal Pressure Hydrocephalus

NCT03521518
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Conner's Continuous Performance Test-3
Diagnostic Test
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
8 participants
Timeline
2019 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jun 26, 2026, 4:10 AM EDT
Terminated Phase 3 Interventional Results available

Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus

NCT01092546
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
[18F]Flutemetamol
Drug
Lead sponsor
GE Healthcare
Industry
Eligibility
50 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 12, 2013 · Synced Jun 26, 2026, 4:10 AM EDT
Terminated Not applicable Interventional

Anterior Pituitary Function in Patients With Hydrocephalus

NCT00149721
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Ventriculo-peritonal shunting
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 1, 2010 · Synced Jun 26, 2026, 4:10 AM EDT
Completed Phase 3 Interventional Results available

PET Imaging of Brain Amyloid in Normal Pressure Hydrocephalus

NCT01053312
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
[18F] Flutemetamol
Drug
Lead sponsor
GE Healthcare
Industry
Eligibility
50 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 10, 2012 · Synced Jun 26, 2026, 4:10 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies

NCT04020198
View directory record Official record
Conditions
Parkinson Disease, Multiple System Atrophy, Rapid Eye Movement Sleep Behavior Disorder, Normal Pressure Hydrocephalus
Interventions
Biomarker assay
Other
Lead sponsor
Stony Brook University
Other
Eligibility
50 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Jun 26, 2026, 4:10 AM EDT
Terminated No phase listed Observational

Prognostic Value of Aβ Imaging in NPH Prior to Shunt Placement

NCT01834625
View directory record Official record
Conditions
Normal Pressure Hydrocephalus Patients
Interventions
PET scan
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 31, 2022 · Synced Jun 26, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial

NCT03350750
View directory record Official record
Conditions
Idiopathic Normal Pressure Hydrocephalus (INPH)
Interventions
programmable CSF shunt valve
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
4
States / cities
Baltimore, Maryland • Albuquerque, New Mexico • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Jun 26, 2026, 4:10 AM EDT
Completed Phase 4 Interventional

ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients

NCT01323764
View directory record Official record
Conditions
Hydrocephalus
Interventions
ShuntCheck test
Device
Lead sponsor
NeuroDx Development
Industry
Eligibility
35 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 19, 2015 · Synced Jun 26, 2026, 4:10 AM EDT
Completed No phase listed Observational

A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus

NCT01115270
View directory record Official record
Conditions
Hydrocephalus, Normal Pressure
Interventions
Non-invasive measures
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
40 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 8, 2016 · Synced Jun 26, 2026, 4:10 AM EDT
Completed No phase listed Observational

Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

NCT00600795
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
CSF collection
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Jun 26, 2026, 4:10 AM EDT
Completed Not applicable Interventional

Neurology Inpatient Clinical Education Trial

NCT03826056
View directory record Official record
Conditions
Myasthenia Gravis, Guillain-Barre Syndrome, Multiple Sclerosis, Seizures, Parkinsonism, Meningitis, Encephalitis, Headache, Vestibular Disorder, Spondylosis, Normal Pressure Hydrocephalus
Interventions
Current standard discharge educational intervention, Personalized discharge educational intervention
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 95 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Jun 26, 2026, 4:10 AM EDT