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Showing 1–24 of 205 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Harm Clear all
Recruiting No phase listed Observational Accepts healthy volunteers

Harm Reduction in HIV Primary Care for PLWH Who Use Drugs

NCT05404750
View directory record Official record
Conditions
Human Immunodeficiency Virus, Substance Use, Stigma, Social
Interventions
Harm Reduction
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
768 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
3
States / cities
Birmingham, Alabama • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cannabis Edibles Packaging Descriptors Experiment

NCT06171399
View directory record Official record
Conditions
Cannabis Use
Interventions
"All Natural" descriptor, "Gluten-free" descriptor, "Vegan" descriptor, "100% Organic" descriptor, "Handcrafted" descriptor, "Made with live resin" descriptor, "Fast-acting" descriptor, "Relax" descriptor, "Energy Boost" descriptor, No descriptor (control)
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 65 Years
Enrollment
2,521 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Healthy Living as You Age

NCT00379093
View directory record Official record
Conditions
Alcohol Related Disorders, Alcohol Drug Interactions
Interventions
Brief advice
Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
55 Years and older
Enrollment
631 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2009 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional Results available

Open Trial of a Behavioral Activation Telepsychology Intervention for People Who Inject Drugs

NCT04943432
View directory record Official record
Conditions
Intravenous Drug Usage
Interventions
Behavioral Activation
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Recruiting Not applicable Interventional

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

NCT06948058
View directory record Official record
Conditions
Smoking Cessation, Obesity and Obesity-related Medical Conditions
Interventions
Electronic Cigarettes (EC), Nicotine replacement therapy (NRT)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Terminated Not applicable Interventional Results available

Analysis of Aldehyde Biomarkers of Exposure and Host Response

NCT00482690
View directory record Official record
Conditions
Smoking Cessation
Interventions
nicotine polacrilex, nicotine transdermal system, nicotine inhaler
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Group-based Intervention for Club Patrons

NCT03652688
View directory record Official record
Conditions
Drink Too Much, Drinking, Binge, Drunk, Drug Use, Aggression, Aggression Sexual, Peer Group, Safety Issues, Harm Reduction
Interventions
Nightlife Safety Plans (NSP), Fire Safety
Behavioral
Lead sponsor
Pacific Institute for Research and Evaluation
Other
Eligibility
21 Years and older
Enrollment
959 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Switching to E-cigarettes in Smokers Not Interested in Quitting

NCT05703672
View directory record Official record
Conditions
Smoking Reduction
Interventions
Varenicline Tartrate, Placebo, Electronic cigarette
Drug · Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 28, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Active, not recruiting Not applicable Interventional

Peer Engagement in Methamphetamine Harm-Reduction With Contingency Management (PEER-CM)

NCT05700994
View directory record Official record
Conditions
Methamphetamine Abuse
Interventions
Peer Contingency Management, Standard of Care Contingency Management
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 105 Years
Enrollment
1,283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Withdrawn Not applicable Interventional

Warrior CARE: Naturalistic Observation and Harm Reduction

NCT05386862
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Cannabis Use, Suicide
Interventions
Reduce THC Use
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
19 Years to 69 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional Results available

Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

NCT06472869
View directory record Official record
Conditions
Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions
NJOY ACE e-cigarette
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Recruiting Not applicable Interventional

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

NCT06768814
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Use
Interventions
Sub-acute stabilization
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Not listed No phase listed Observational

Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder

NCT05209217
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Ketamine
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
14 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 26, 2022 · Synced Jun 26, 2026, 4:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cannabis Observational Study on Mood, Inflammation, and Cognition

NCT03522103
View directory record Official record
Conditions
Inflammation, Inflammatory Response, Mood, Cognitive Change
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 70 Years
Enrollment
421 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 11, 2021 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 1Phase 2 Interventional

Stonewall Treatment Evaluation Project

NCT01129401
View directory record Official record
Conditions
Substance Abuse, HIV Infections
Interventions
Stonewall Project
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Male only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 26, 2014 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 2 Interventional Results available

Harm Reduction With Pharmacotherapy (HaRP)

NCT01932801
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
XR-NTX, Placebo, HRC
Drug · Other · Behavioral
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 65 Years
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Terminated Phase 2 Interventional Results available

Complement Regulation to Undo Systemic Harm in Preeclampsia

NCT04725812
View directory record Official record
Conditions
Preeclampsia, Severe Preeclampsia, Eculizumab, HELLP, HELLP Syndrome, HELLP Syndrome Second Trimester, Pregnancy Related, AHUS, PNH, Complement Regulatory Factor Defect, Complement Abnormality, HELLP Syndrome Third Trimester
Interventions
Eculizumab
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
13 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional

Patient Navigation-based Tobacco Harm Reduction Program Among Cancer Patients

NCT04972916
View directory record Official record
Conditions
Tobacco Use
Interventions
Patient navigation-based tobacco harm reduction intervention
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Jun 26, 2026, 4:06 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Implementing a Brief Suicide Intervention for High Risk Youth With Front-Line Juvenile Justice Staff

NCT02981420
View directory record Official record
Conditions
Suicide and Self Harm
Interventions
Safety planning
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
12 Years to 17 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 5, 2017 · Synced Jun 26, 2026, 4:06 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Innovating Technology Solutions for Residents in Support Housing Communities w SUD Through Community-Engaged Research

NCT07001020
View directory record Official record
Conditions
Housing Problems, Household Substance Abuse, Substance Use Disorders, Harm Reduction
Interventions
Technology-based Intervention
Behavioral
Lead sponsor
Oregon Research Behavioral Intervention Strategies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Springfield, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jun 26, 2026, 4:06 PM EDT
Recruiting Phase 2 Interventional

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

NCT05304065
View directory record Official record
Conditions
Suicide, Suicidal, Self-Harm
Interventions
SAFETY-A within usual ED Care, Combined SAFETY-A within usual ED Care + CLASP Therapeutic Follow-Up Contacts
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 24 Years
Enrollment
1,600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
5
States / cities
Los Angeles, California • Sylmar, California • Durham, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Jun 26, 2026, 4:06 PM EDT
Not listed Not applicable Interventional

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

NCT05327439
View directory record Official record
Conditions
Smoking, Cigarette, Nicotine Dependence
Interventions
Nicotine (electronic cigarette), Nicotine (nicotine pouch)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Not applicable Interventional

CAMS-G Group Therapy for Suicidal Veterans

NCT03682406
View directory record Official record
Conditions
Suicide and Self-harm
Interventions
CAMS-G
Behavioral
Lead sponsor
Louisville VA Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Jun 26, 2026, 4:06 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Treatment for Non-Suicidal Self-Injury in Young Adults

NCT01018433
View directory record Official record
Conditions
Non-suicidal Self-injury
Interventions
T-SIB, Treatment as usual
Behavioral · Other
Lead sponsor
Fordham University
Other
Eligibility
18 Years to 29 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Jun 26, 2026, 4:06 PM EDT