Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results come from ClinicalTrials.gov. When the live registry is unavailable, a clearly labeled stored copy may be shown.

Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 20, 2026, 2:30 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 125 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Harm Reduction Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention

NCT06852170
View directory record Official record
Conditions
Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making, Organizations, Substance-related Disorders, Policy
Interventions
Co-Design Sessions (CDS), Data products
Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
341 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System

NCT07879638
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
FT25614, FT25615, FT25616
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
4
States / cities
Atlanta, Georgia • Chicago, Illinois • Iselin, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

NCT06526286
View directory record Official record
Conditions
Medication Abuse, Harm Reduction, Opioid Use Disorder, Supportive Care
Interventions
Medications for Opioid Use Disorder Pathway Clinical Decision Support (CDS)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 89 Years
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers

NCT07710820
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
31237616, 31237617, 31237571, 31237581
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
1,060 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
9
States / cities
Brandon, Florida • Coral Springs, Florida • Aurora, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Phase 2 Interventional Results available

Harm Reduction With Pharmacotherapy (HaRP)

NCT01932801
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
XR-NTX, Placebo, HRC
Drug · Other · Behavioral
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 65 Years
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting No phase listed Observational

Shelter HArm Reduction Evaluation

NCT07170072
View directory record Official record
Conditions
Overdose, Harm Reduction
Interventions
Not listed
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Active, not recruiting Not applicable Interventional

Peer Engagement in Methamphetamine Harm-Reduction With Contingency Management (PEER-CM)

NCT05700994
View directory record Official record
Conditions
Methamphetamine Abuse
Interventions
Peer Contingency Management, Standard of Care Contingency Management
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 105 Years
Enrollment
1,283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional

The OPT-IN Project

NCT03526380
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Behavioral: the OPT-IN Intervention
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Usability Assessment of Naloxone Administration by Untrained Community Members

NCT04025671
View directory record Official record
Conditions
Harm Reduction, Opioid-use Disorder, Naloxone
Interventions
Nasal Spray Naloxone, Intramuscular Naloxone, Improvised Nasal Atomizer
Device
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years and older
Enrollment
208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jul 19, 2019 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine

NCT00777569
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 16, 2017 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NCT06372899
View directory record Official record
Conditions
E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions
E-cigarettes, Oral nicotine pouches
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Opioid Overdose Mortality in the United States

NCT03924505
View directory record Official record
Conditions
Opioid Overdose
Interventions
Organize and Mobilize for Implementation Effectiveness, Dissemination
Other
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine

NCT05994703
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
d-cycloserine, Juul e-cigarette
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine

NCT00710034
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Oral tobacco, Nicotine Gum
Other · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
391 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
2
States / cities
Minneapolis, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 6, 2017 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

THRIVE: Culturally AdapTed Harm Reduction Intervention

NCT06609278
View directory record Official record
Conditions
Opioid Use, Stimulant Use
Interventions
harm reduction intervention
Behavioral
Lead sponsor
Brittany Miller-Roenigk
Other
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
3
States / cities
Louisville, Kentucky • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy

NCT06859710
View directory record Official record
Conditions
Abuse, Drug, Pain
Interventions
Placebo, THC, CBD 20 mg, CBD 40 mg, CBD 80 mg
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

Open Trial of a Behavioral Activation Telepsychology Intervention for People Who Inject Drugs

NCT04943432
View directory record Official record
Conditions
Intravenous Drug Usage
Interventions
Behavioral Activation
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

NCT05815199
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco

NCT03860077
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes, Uncomplicated
Interventions
Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Drug
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 19, 2023 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

NCT07698470
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Oral Nicotine Pouch, Smoking Cue Reactivity Task
Other · Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Video-Based Intervention in Reducing Anxiety in Patients Undergoing Lung Cancer Screening

NCT02288416
View directory record Official record
Conditions
Anxiety, No Evidence of Disease, Lung Carcinoma
Interventions
educational intervention, questionnaire administration, quality-of-life assessment, Best Practice
Other
Lead sponsor
City of Hope Medical Center
Other
Eligibility
55 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

Switching to Potential Reduced Exposure Products in Adult Smokers

NCT04250727
View directory record Official record
Conditions
Tobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm Reduction, Toxic Effect of Tobacco and Nicotine, Carcinogenesis
Interventions
ZYN
Device
Lead sponsor
Yale University
Other
Eligibility
21 Years to 77 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional

Novel Approaches to Reducing Tobacco Related Harm

NCT02600273
View directory record Official record
Conditions
Smoking, Tobacco Smoking Behavior, Cigarette Smoking
Interventions
Usual brand cigarettes, Lower nicotine content cigarettes, Electronic cigarettes 1, Electronic cigarettes 2
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

NCT06678789
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence, Smoking Cessation
Interventions
High Nicotine Dose, Low Nicotine Dose
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 20, 2026, 2:30 PM EDT