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ClinicalTrials.gov public records Last synced Oct 18, 2026, 2:40 PM EDT

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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Harmful Use Clear all
Completed Phase 2 Interventional Results available

N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI

NCT02791945
View directory record Official record
Conditions
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Interventions
Medical Management Counseling, N-acetylcysteine, Placebo
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 11, 2021 · Synced Oct 18, 2026, 2:40 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Preventing Alcohol Use Disorders and Alcohol-Related Harms in Pacific Islander Young Adults

NCT06337721
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol; Harmful Use
Interventions
SPEAR (Strategies for Pacific Empowerment and Alcohol Reduction)
Behavioral
Lead sponsor
University of California, Riverside
Other
Eligibility
18 Years to 30 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2024 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A PPG Sensor-Based Feedback Intervention for Heavy Drinking Young Adults

NCT05090995
View directory record Official record
Conditions
Heavy Drinking, Harmful; Use, Alcohol
Interventions
Behavioral Self-Management and Feedback, Behavioral Self-Management
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 25 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Game Plan: Efficacy of a Brief, Web-based Intervention on Alcohol Use and Sexually-transmitted Infections

NCT04552171
View directory record Official record
Conditions
Sexually Transmitted Diseases, Bacterial, Alcohol; Harmful Use
Interventions
Access to Game Plan app and 24-hour helpline
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional

Testing A Couple-based Program for Alcohol Risk Reduction in the National Guard

NCT03589508
View directory record Official record
Conditions
Alcohol; Harmful Use
Interventions
In-person sessions: ABCP_P, Video conference sessions: ABCP_T
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional

Recovery Housing and Drug Abuse Treatment Outcome

NCT03278496
View directory record Official record
Conditions
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Interventions
Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Oct 18, 2026, 2:40 PM EDT
Active, not recruiting Not applicable Interventional

Pain and Opioids: Integrated Treatment In Veterans

NCT04648228
View directory record Official record
Conditions
Chronic Pain, Opioid-use Disorder, Opioids; Harmful Use
Interventions
ACT+MBRP, Education control
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years to 75 Years
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
San Francisco, California • Albuquerque, New Mexico • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Insomnia Treatment and Problems (the iTAP Study)

NCT03627832
View directory record Official record
Conditions
Insomnia, Alcohol; Harmful Use
Interventions
Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep Hygiene
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 30 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional

Adapting CBT-I for Hazardous Alcohol Users

NCT05973955
View directory record Official record
Conditions
Insomnia, Harmful; Use, Alcohol
Interventions
Insomnia Treatment, Education Control
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
25 Years to 64 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Results available

Social Support Intervention for Addiction Recovery

NCT06022107
View directory record Official record
Conditions
Alcohol; Harmful Use, Alcohol
Interventions
LDART
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

MI With Text Messaging to Reduce Sexual Risk and Hazardous Drinking Among MSM

NCT03755661
View directory record Official record
Conditions
Alcohol; Harmful Use, Sex, Unsafe
Interventions
MI&TXT4MSM
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2021 · Synced Oct 18, 2026, 2:40 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study

NCT06687525
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use, Alcoholism, Binge Drinking
Interventions
Not listed
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 30 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Computerized Brief Alcohol Intervention (BI) for Binge Drinking HIV At-Risk and Infected Women

NCT01125371
View directory record Official record
Conditions
Alcohol; Harmful Use, Binge Drinking, Risk Behavior, HIV Infection
Interventions
Computerized brief alcohol intervention + IVR booster calls, Computerized brief alcohol intervention, Attention Control
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
439 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 24, 2022 · Synced Oct 18, 2026, 2:40 PM EDT
Not listed Not applicable Interventional

Patient Education Video to Reduce OTC NSAIDs

NCT06575205
View directory record Official record
Conditions
Chronic Kidney Diseases, Heart Failure, Hypertension
Interventions
Educational video
Behavioral
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
1,452 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Game Plan for PrEP

NCT04973267
View directory record Official record
Conditions
Human Immunodeficiency Virus Exposure, Alcohol; Harmful Use
Interventions
Game Plan for PrEP, Attention-Matched Control Lifestyle Habits Videos
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Oct 18, 2026, 2:40 PM EDT
Not yet recruiting Not applicable Interventional

Integrated Digital Health Approach to Reduce Hazardous Alcohol Use and Chronic Pain Among Rural Populations

NCT07804914
View directory record Official record
Conditions
Chronic Pain, Unhealthy Alcohol Use
Interventions
Mobile Intervention for Alcohol and Pain, Control Intervention
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Phase 4 Interventional Results available

Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI

NCT01750268
View directory record Official record
Conditions
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Interventions
Medical Management Counseling, Topiramate, Placebo
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Summative Assessment of the BurntOut 3D Simulation With Medical Students

NCT04494633
View directory record Official record
Conditions
Burnout, Student, Alcohol; Harmful Use, Quality of Life, Depression, Resilience, Drug Use, Burnout, Professional
Interventions
Clinical Encounters Medical School 3D Simulation
Other
Lead sponsor
Clinical Tools, Inc.
Industry
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 15, 2023 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement

NCT05283980
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute, Pain, Chest, Pain, Satisfaction, Patient, Opioid Use, Unspecified, Opioids; Harmful Use
Interventions
0.25% Bupivacaine
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Insomnia Treatment and Problems Study for Veterans

NCT03804788
View directory record Official record
Conditions
Insomnia, Alcohol; Harmful Use
Interventions
Cognitive Behavioral Therapy for Insomnia, Sleep Hygeine
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Results available

Acceptability of Less Harmful Alternatives to Cigarettes

NCT00957424
View directory record Official record
Conditions
Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions
telephone-based intervention, nicotine replacement therapy, informational intervention, internet-based intervention, questionnaire administration
Behavioral · Drug · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 120 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 7, 2017 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches

NCT05664672
View directory record Official record
Conditions
Tobacco Use
Interventions
OTDN Product 1, OTDN Product 2, OTDN Product 3, No Tobacco
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
3
States / cities
Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Oct 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Understanding Alcohol Reward in Social Context

NCT03449095
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use, Alcoholism, Binge Drinking
Interventions
Alcohol
Drug
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 30 Years
Enrollment
640 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Oct 18, 2026, 2:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Piloting a Naloxone Intervention in Philadelphia

NCT03305497
View directory record Official record
Conditions
Opioids; Harmful Use
Interventions
Mobile Phone Application
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Oct 18, 2026, 2:40 PM EDT