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Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Head and Neck Lymphedema Clear all
Recruiting Not applicable Interventional

Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients

NCT06708754
View directory record Official record
Conditions
Radiation Lymphedema, Radiation Fibrosis, Head and Neck Cancer
Interventions
Photobiomodulation (PBM) Therapy, Sham PBM
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Response to Intermittent Pneumatic Compression Therapy in Head and Neck Cancer-Related Lymphedema

NCT02946021
View directory record Official record
Conditions
Head and Neck Neoplasms, Head and Neck Lymphedema, Head and Neck Cancer
Interventions
Head and neck garments for pneumatic compression device, NIRFLI with ICG
Device · Drug
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Jul 22, 2026, 5:50 AM EDT
Recruiting Not applicable Interventional

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

NCT06837480
View directory record Official record
Conditions
Head and Neck Cancer, Lymphedema of the Head and Neck
Interventions
LTU-904 Portable Laser Therapy Unit (active laser device), LTU-904 Portable Laser Therapy Unit (sham/inactive laser device)
Device
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 22, 2026, 5:50 AM EDT
Completed No phase listed Observational

The Fibrosis-Lymphedema Continuum in Head and Neck Cancer

NCT01187173
View directory record Official record
Conditions
Head and Neck Neoplasms, Fibrosis, Lymphedema, Biomarkers, Polymorphism, Genetic, Depression
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 9, 2017 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Not applicable Interventional Results available

Self-Care for Head and Neck Cancer Survivors With Lymphedema and Fibrosis

NCT03030859
View directory record Official record
Conditions
Head and Neck Cancer, Lymphedema, Fibrosis
Interventions
Usual Care, Usual Care plus LEF-SCP, Usual Care plus LEF-SCP plus Follow-up
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study to Evaluate the Feasibility and Potential Effectiveness of the Flexitouch System Head and Neck Treatment

NCT03332160
View directory record Official record
Conditions
Head and Neck Neoplasms, Head and Neck Cancer, Head and Neck Lymphedema
Interventions
Flexitouch head and neck lymphedema treatment system, Standard home lymphedema care
Device · Other
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Springfield, Illinois • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Not applicable Interventional

Complete Decongestive Therapy on Head and Neck Lymphedema

NCT04045860
View directory record Official record
Conditions
Lymphedema of Face, Secondary Lymphedema
Interventions
Complete Decongestive Therapy, Observation
Procedure · Other
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 7, 2021 · Synced Jul 22, 2026, 5:50 AM EDT
Terminated Not applicable Interventional

Determining Swallow Outcomes in Head & Neck Lymphedema Subjects Receiving Early Intervention With Pneumatic Compression

NCT04335981
View directory record Official record
Conditions
Head and Neck Lymphedema
Interventions
FT-CC and Swallow Exercises, Swallow Exercises
Device · Other
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Jul 22, 2026, 5:50 AM EDT
Terminated No phase listed Observational Results available

A Registry to Evaluate the Flexitouch System and Flexitouch Plus for Treatment of Head and Neck Lymphedema

NCT03558672
View directory record Official record
Conditions
Head and Neck Lymphedema
Interventions
Flexitouch system with Head and Neck Garments
Device
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
West Des Moines, Iowa • Asheville, North Carolina • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Jul 22, 2026, 5:50 AM EDT
Active, not recruiting Not applicable Interventional

Comparing Two Ways to Manage Head and Neck Lymphedema

NCT05182229
View directory record Official record
Conditions
Head and Neck Cancer, Lymphedema
Interventions
Home-based (a hybrid model) CDT, Clinic-based CDT
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
6
States / cities
Cherry Hill, New Jersey • Philadelphia, Pennsylvania • Willow Grove, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 22, 2026, 5:50 AM EDT
Recruiting Phase 2 Interventional

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

NCT06912763
View directory record Official record
Conditions
Fibrosis Syndrome, Lymphedema, Head &Amp; Neck Cancer, Fibrosis
Interventions
Pravastatin (drug), Pentoxifylline, ketoprofen, Pirfenidoneone, Standard of Care (SOC), tocopherol
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2033
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Jul 22, 2026, 5:50 AM EDT
Withdrawn Not applicable Interventional

Lymphedema Treatment in Head and Neck Cancer Patients

NCT04276454
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Flexitouch Plus system
Device
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Not applicable Interventional Results available

A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema

NCT04797390
View directory record Official record
Conditions
Lymphedema, Lymphedema of Face, Lymphedema, Secondary, Lymphedema Due to Radiation, Lymphedema; Surgical
Interventions
Advanced Pneumatic Compression Device (APCD), Usual Care
Device · Other
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
10
States / cities
Birmingham, Alabama • Chicago, Illinois • Louisville, Kentucky + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jul 22, 2026, 5:50 AM EDT
Completed No phase listed Observational

Impact of Secondary Lymphedema on Symptoms, Functional Status, and Quality of Life After Treatment in Patients With Head and Neck Cancer

NCT01098669
View directory record Official record
Conditions
Cancer Survivor, Head and Neck Cancer, Lymphedema
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Not applicable Interventional Results available

Low-Level Laser in Treatment of Head and Neck Lymphedema: A Pilot Study

NCT03738332
View directory record Official record
Conditions
Head and Neck Cancer, Lymphedema, Fibrosis
Interventions
Low-Level Laser
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 31, 2022 · Synced Jul 22, 2026, 5:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Developing a Checklist of Lymphedema Symptoms in Patients With Head and Neck Cancer

NCT00840814
View directory record Official record
Conditions
Head and Neck Cancer, Lymphedema
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
20 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
3
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Jul 22, 2026, 5:50 AM EDT
Recruiting Not applicable Interventional

Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

NCT06125743
View directory record Official record
Conditions
Lymphedema of the Head and Neck
Interventions
Usual Care, In-Person LEF-SMP, Telehealth LEF-SMP
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 22, 2026, 5:50 AM EDT
Completed No phase listed Observational

Skin/Soft Tissue Elasticity in Head and Neck Cancer Survivors With Lymphedema and Fibrosis

NCT02676752
View directory record Official record
Conditions
Lymphedema
Interventions
Medical Examination, Questionnaire Administration, Shear Wave Elastography
Procedure · Other
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
22 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 8, 2022 · Synced Jul 22, 2026, 5:50 AM EDT
Not yet recruiting Not applicable Interventional

Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction

NCT07694726
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Facial Vein Reconstruction
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Not applicable Interventional Results available

Low-Level Laser in Head and Neck Chronic Lymphedema

NCT04482855
View directory record Official record
Conditions
Head and Neck Cancer, Lymphedema, Fibrosis
Interventions
Low-level laser
Device
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Jul 22, 2026, 5:50 AM EDT
Enrolling by invitation Phase 1 Interventional

Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship

NCT05937269
View directory record Official record
Conditions
Lymphedema of Face, Head and Neck Cancer
Interventions
Near-infrared fluorescence lymphatic imaging, advanced pneumatic compression therapy
Combination Product · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Jul 22, 2026, 5:50 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Home-Based Lymphedema Care Program (HBLCP) in Improving Lymphedema Self-Care in Head and Neck Cancer Survivors

NCT02170272
View directory record Official record
Conditions
Head and Neck Cancer, Lymphedema
Interventions
Home-based Lymphedema Care Program
Behavioral
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Jul 22, 2026, 5:50 AM EDT
Completed Not applicable Interventional

Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients

NCT02412241
View directory record Official record
Conditions
Oral Cavity Cancer, Oropharyngeal Cancer, Lymphedema, Fibrosis
Interventions
LEF measures, Technical measure
Other · Procedure
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
21 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Jul 22, 2026, 5:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Skin Biophysical Measures for Assessing Head and Neck Cancer-Related External Lymphedema

NCT04457375
View directory record Official record
Conditions
Lymphedema, Secondary
Interventions
TDC
Diagnostic Test
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Jul 22, 2026, 5:50 AM EDT