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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:58 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 882 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Headache Disorder Clear all

Conditions: Migraine
Interventions: Telehealth Behavioral Migraine Management, Education Modules; Behavioral
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Migraine
Interventions: dihydroergotamine mesylate; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Concussion, Headache
Interventions: Lidocaine in SphenoCath device, Saline Solution in SphenoCath device; Combination Product
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 60 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Headache, Migraine
Interventions: ethosuximide, placebo comparator; Drug · Other
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Migraine
Interventions: MBCT for Migraine; Behavioral
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Migraine
Interventions: Melatonin, Placebo oral capsule; Drug
Lead sponsor: Amy Gelfand; Other
Eligibility: 10 Years to 17 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: Los Angeles, California • San Francisco, California

Conditions: Migraine
Interventions: Acupuncture; Device
Lead sponsor: Mike O'Callaghan Military Hospital; Federal
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Nellis Air Force Base, Nevada

Conditions: Headache, Migraine
Interventions: Ropivacaine, Normal saline; Drug
Lead sponsor: Robert Hickey; Other
Eligibility: 7 Years to 17 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Migraine
Interventions: Ubrogepant 100 mg, Placebo; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 518 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 73
States / cities: Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 65 more

Conditions: Migraine
Interventions: HIT-6 Questionnaire, Avulux Spectacles, Sham Spectacles; Other · Device
Lead sponsor: Avulux, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Post-Traumatic Headaches
Interventions: Occipital Nerve Block (ONB) using lidocaine and dexamethosone, Cervical Medial Branch Block (CMBB) using lidocaine and dexamethosone; Drug
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 14 Years to 45 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Tinnitus
Interventions: Nortriptyline, Topiramate, Paroxetine, Verapamil; Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 25 Years to 85 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Orange, California

Conditions: Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes, Headache, Traumatic Brain Injury, Post Concussion Symptoms
Interventions: HIRREM; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 11 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Chronic Migraine
Interventions: IONIS-PKKRx (ISIS 546254), Placebo; Drug · Other
Lead sponsor: Smith, Timothy R., M.D.; Individual
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: City of Saint Peters, Missouri • Springfield, Missouri

Conditions: Cluster Headache
Interventions: Depacon IV and Depakote ER; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Postdural Puncture Headache
Interventions: Morphine, Sterile normal saline; Drug
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 4
States / cities: Newark, New Jersey • New York, New York

Conditions: Migraine Headache, Aura
Interventions: Inhaled Placebo, Inhaled PCZ 5 mg, Inhaled PCZ 7.5 mg, Inhaled PCZ 10 mg; Drug
Lead sponsor: Alexza Pharmaceuticals, Inc.; Other
Eligibility: 18 Years to 70 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 25
States / cities: Scottsdale, Arizona • San Francisco, California • Santa Monica, California + 22 more

Conditions: Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache, Mild Traumatic Brain Injury, Posttraumatic Migraine
Interventions: prazosin hydrochloride, placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Migraine Disorders, Aphasia
Interventions: Language treatment; Behavioral
Lead sponsor: Quality Living, Inc.; Other
Eligibility: 19 Years to 65 Years
Enrollment: 1 participant
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Obesity, Rhinitis, Rhinitis, Allergic, Respiratory Sounds, Dyspnea, Headache, Migraine Disorders, Arthritis, Arthralgia, Anxiety, Sleep Initiation and Maintenance Disorders, Sleep Deprivation
Interventions: Vitamin A, Vitamin B6, Vitamin C, Nicotinamide, Vitamin D3, Vitamin E, Broccoli, Spinach, Caffeine, Coffee, Axon Eyewear, Chocolate; Dietary Supplement · Other · Device
Lead sponsor: Verifomics LLC; Industry
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Brain Injuries, Traumatic, Chronic Pain, Post-Traumatic Headache
Interventions: Collaborative Care; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 2
States / cities: Seattle, Washington

Conditions: Migraine Headache
Interventions: Placebo, LY2300559; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 11
States / cities: Phoenix, Arizona • Long Beach, California • Fairfield, Connecticut + 8 more

Conditions: Migraine Disorders
Interventions: Emotional Awareness and Expression Therapy (EAET); Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Facet Joints; Degeneration, Neuropathy, Neuralgia
Interventions: Cryoablation under image guidance, MRI Seednet Cryotherapy System (Galil Medical); Procedure · Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Search by objective public record fields.

Telehealth Behavioral Migraine Management

A Study Examining the Use of a Migraine Medicine in the Treatment of Two Migraine Attacks in Patients Who Have Increased Skin Sensitivity

Sphenopalatine Ganglion Block for Headache After Concussion

Comparison of a Drug and Placebo in the Prevention of Migraine Headaches

Bronx MBCT-Migraine

Melatonin for Adolescent Migraine Prevention Study

An Exploratory Prospective Trial of Rescue Acupuncture for the Treatment of Acute Migraine

Study of Intramuscular Ropivacaine Injections for Treatment of Pediatric Headache

Study to Evaluate Oral Ubrogepant in the Acute Treatment of Migraine During the Prodrome in Adult Participants

Optical Treatment of Migraines Using the Avulux™ Optical Filter in the Form of Spectacle Lenses.

A Prospective Controlled Treatment Trial for Post-Traumatic Headaches

Management of Acute Tinnitus With Migraine Medications

HIRREM Developmental Study

Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine

An Open Label Study Using Consecutive Intravenous Depacon With Oral Depakote ER for the Treatment of Cluster Headaches.

2 Dose Neuraxial Morphine for Prevention of PDPH

Staccato Prochlorperazine in Migraine (Out Patient)

Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application

TBI Care: Collaborative Care for Pain After Traumatic Brain Injury (TBI)

A Study in Migraine Prevention

Emotional Awareness and Expression Therapy (EAET) as a Novel Migraine Treatment

MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine