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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Headache Disorders, Secondary Clear all
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache

NCT03112720
View directory record Official record
Conditions
Postdural Puncture Headache
Interventions
Epidural Blood Patch, Sphenopalatine Ganglion Block
Device · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
13 Years to 92 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Phase 2 Interventional Results available

A Study to Test if Fremanezumab Reduces Headache in Participants With Posttraumatic Headache (PTH)

NCT03347188
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Fremanezumab, Placebo
Drug
Lead sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
33
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 29 more
Source: ClinicalTrials.gov public record
Updated Dec 12, 2022 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Phase 4 Interventional Results available

A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache

NCT05452239
View directory record Official record
Conditions
Migraine, Medication Overuse Headache
Interventions
Eptinezumab, Placebo
Drug
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
18 Years to 75 Years
Enrollment
608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
6
States / cities
Winter Haven, Florida • Marrero, Louisiana • Springfield, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 28, 2026, 1:39 PM EDT
Terminated Phase 2 Interventional Results available

Pilot Study of DFN-11 Injection in Medication Overuse Headache

NCT02583425
View directory record Official record
Conditions
Medication Overuse Headache
Interventions
DFN-11 Injection
Drug
Lead sponsor
Dr. Reddy's Laboratories Limited
Industry
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Sep 28, 2026, 1:39 PM EDT
Terminated Not applicable Interventional

Brain Biomarkers w/Mind-Body Tx in Veterans With Post Traumatic Headache (PTH)

NCT02145117
View directory record Official record
Conditions
Post Traumatic Headache
Interventions
MBSR
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 28, 2026, 1:39 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Multi Cervical Unit Measures of Cervical Isometric Strength and Range of Motion: A Pilot Study

NCT00510757
View directory record Official record
Conditions
Cervicogenic Headache, Neck Pain, Whiplash, Kyphotic and Reversed Cervical Curves
Interventions
Not listed
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 16, 2008 · Synced Sep 28, 2026, 1:39 PM EDT
Recruiting Phase 1Phase 2 Interventional

Treating Chronic Cervicogenic Head and Neck Pain

NCT05617365
View directory record Official record
Conditions
Cervicogenic Headache, Neck Pain, Posterior
Interventions
Osteopathic Manipulative Therapy and Exercise Therapy
Combination Product
Lead sponsor
Michigan State University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 28, 2026, 1:39 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study to Evaluate Biomarker Signature to Predict the Persistence of Post-traumatic Headache

NCT06132529
View directory record Official record
Conditions
Post-Traumatic Headache, Healthy
Interventions
Brain Magnetic Resonance Imaging (MRI) Scan, Speech Sample, Electronic Daily Headache Diary
Diagnostic Test · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
2
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Early Phase 1 Interventional

The Effect of Botulinum Toxin A on Headache Attributed to TMD

NCT03346252
View directory record Official record
Conditions
Secondary Headache Disorder
Interventions
Botulinum Toxin type A
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 74 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 28, 2026, 1:39 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction

NCT00487578
View directory record Official record
Conditions
Post Traumatic Headache
Interventions
naratriptan HCl
Drug
Lead sponsor
Cady, Roger, M.D.
Individual
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
3
States / cities
Springfield, Missouri • Charlotte, North Carolina • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2013 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Not applicable Interventional

Mobilization Versus Manipulation for the Treatment of Cervicogenic Headaches

NCT03919630
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Thrust Mobilization, Non-Thrust Mobilizations
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Psychological Assessment and Treatment of Chronic Benign Headache

NCT00018811
View directory record Official record
Conditions
Headache, Migraine, Tension Headache, Stress Headache, Vascular Headache
Interventions
Relaxation training & thermal biofeedback, Surface EMG biofeedback
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2003
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Phase 4 Interventional Results available

Dexamethasone for Post Traumatic Headache

NCT04799015
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Dexamethasone, Metoclopramide 10mg
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
16 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Phase 4 Interventional

The Effect of Galcanezumab-gnlm on Post-Traumatic, Migrainous Headaches

NCT06901518
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Galcanezumab-Gnlm
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Sep 28, 2026, 1:39 PM EDT
Active, not recruiting Not applicable Interventional

The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain

NCT05491915
View directory record Official record
Conditions
Cervicogenic Headache, Occipital Neuralgia
Interventions
SPRINT Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
10
States / cities
Santa Rosa, California • Waltham, Massachusetts • Rochester, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Phase 1 Interventional

Efficacy of Percutaneous SPG Block in Aneurysmal SAH

NCT04331938
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Headache
Interventions
Regional anesthetic SPG block-bilateral
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Sep 28, 2026, 1:39 PM EDT
Terminated Phase 4 Interventional Results available

Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines

NCT02090998
View directory record Official record
Conditions
Transformed Migraine, Chronic Daily Headache
Interventions
SPG Block with 5% Lidocaine gel, Amitriptyline
Procedure · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 28, 2026, 1:39 PM EDT
Withdrawn Not applicable Interventional

Caffeine Versus Placebo for Spinal Headaches

NCT00809627
View directory record Official record
Conditions
Post Dural Puncture Headache
Interventions
Caffeine, saline
Drug
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
18 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Phase 4 Interventional Results available

Prazosin for Post-Concussive Headaches

NCT02965027
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Prazosin, Placebo
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Sep 28, 2026, 1:39 PM EDT
Terminated Phase 2 Interventional Results available

Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache

NCT03430531
View directory record Official record
Conditions
Post-Dural Puncture Headache, Sphenopalatine Ganglion Block
Interventions
Lidocaine
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 14, 2022 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Phase 1Phase 2 Interventional

Cervicogenic Headache Dose-Response

NCT01530321
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Spinal Manipulation, Light Massage
Other
Lead sponsor
University of Western States
Other
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Bloomington, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 28, 2026, 1:39 PM EDT
Recruiting Phase 2 Interventional

Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD

NCT06608277
View directory record Official record
Conditions
Posttraumatic Headache, Posttraumatic Stress Disorder
Interventions
Group A active comparator, Group B active comparator, Group C Experimental, Group D Placebo Comparator
Procedure · Drug · Combination Product + 1 more
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Chicago, Illinois • Bethesda, Maryland • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 28, 2026, 1:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology

NCT03674398
View directory record Official record
Conditions
Post-Concussion Syndrome, Post-Traumatic Headache, Post-Concussive Syndrome, Chronic, Head Injury, MTBI - Mild Traumatic Brain Injury, Acquired Brain Injury, Closed Head Injury
Interventions
Exercise+CT, Exercise only
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 28, 2026, 1:39 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Study of Gammacore Sapphire for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)

NCT04071743
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
gammaCore Sapphire, sham gammaCore Sapphire
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 28, 2026, 1:39 PM EDT