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Showing 1–24 of 280 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Healthy Cognition Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Tolperisone on Measures of Drowsiness and Cognitive Function

NCT04407377
View directory record Official record
Conditions
Healthy
Interventions
Tolperisone Hydrochloride, Cyclobenzaprine Hydrochloride 10 MG, Placebo
Drug · Other
Lead sponsor
Neurana Pharmaceuticals, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Long Beach, California • Berlin, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 31, 2022 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Hormone Replacement in Young Women With Premature Ovarian Failure

NCT00001951
View directory record Official record
Conditions
Healthy, Osteoporosis, Premature Ovarian Failure
Interventions
TMTDS
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 32 Years · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2007 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Norms Expansion and Validation for IntelliSpace Cognition

NCT04729257
View directory record Official record
Conditions
Cognitive Functioning of Healthy Individuals
Interventions
Philips IntelliSpace Cognition (ISC)., Paper-Pencil Tests.
Device · Diagnostic Test
Lead sponsor
Philips Electronics Nederland B.V. acting through Philips CTO organization
Industry
Eligibility
18 Years to 95 Years
Enrollment
508 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Newtown Square, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Phase 2 Interventional

Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

NCT07000734
View directory record Official record
Conditions
Aging, Cognitive Decline, Older Adults, Cardiovascular, Sedentary Behaviors, Immune Senescence, Motor Function
Interventions
Risk managment, Dasatinib, Quercetin (dietary supplement), Vortioxetine
Behavioral · Drug · Dietary Supplement
Lead sponsor
Washington University School of Medicine
Other
Eligibility
50 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short-Term Rhodiola Rosea for Anaerobic Performance and Cognitive Function in Resistance-Trained Adults

NCT07225413
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Rhodiola rosea (low dose), Rhodiola rosea (high dose), Placebo capsules
Dietary Supplement
Lead sponsor
Jacksonville State University
Other
Eligibility
18 Weeks to 40 Weeks
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Jacksonville, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 10, 2026, 4:19 AM EDT
Completed No phase listed Observational

Large-Scale Online Studies of Early Motor Skill Learning

NCT03733080
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 120 Years
Enrollment
2,529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 14, 2025 · Synced Sep 10, 2026, 4:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Mobile App to Improve 24-Hour Movement Guideline Adherence in Preschoolers

NCT06667661
View directory record Official record
Conditions
Healthy, 24-Hour Movement Guidelines, Feasibility Studies, Sleep, Physical Activity, Screen Time, Sedentary Behaviors, Motor Skills, Cognition, Parent-Child Relations, Mobile Application, Health Education, Child Development
Interventions
Shining Star mHealth App
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
3 Years to 4 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Sep 10, 2026, 4:19 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Modafinil-Alcohol Interactions in Healthy Volunteers

NCT00305292
View directory record Official record
Conditions
Alcohol
Interventions
Modafinil-Alcohol Interactions
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2011 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise, Cognitive Function and Neuroplasticity in Healthy Adults

NCT02994134
View directory record Official record
Conditions
Sedentary Lifestyle
Interventions
Moderate intensity exercise., High intensity exercise.
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 70 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Sep 10, 2026, 4:19 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function

NCT07079852
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Psilocybin 15mg
Drug
Lead sponsor
Manoj Doss
Other
Eligibility
21 Years to 45 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 10, 2026, 4:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Magnetic Resonance Imaging of Calculus Problem Solving

NCT00060658
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 10, 2026, 4:19 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy

NCT01986764
View directory record Official record
Conditions
Planned RRSO
Interventions
Lisdexamfetamine, Estradiol, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 48 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Direct Current Brain Stimulation on Cognition

NCT00048698
View directory record Official record
Conditions
Electrical Stimulation of the Brain
Interventions
TMS, EEG
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 10, 2026, 4:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

TMS for Cognitive Decline in Aging and Preclinical AD

NCT06956300
View directory record Official record
Conditions
Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
Interventions
Active rTMS, Sham rTMS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Synaquell™ in Contact Sport Athletes

NCT06104670
View directory record Official record
Conditions
Healthy
Interventions
Synaquell(TM), Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 19 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Modafinil on Brain Function in Patients With Schizophrenia

NCT00057707
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Modafinil, Functional MRI, Neuropsychological Testing
Drug · Procedure
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 8, 2019 · Synced Sep 10, 2026, 4:19 AM EDT
Active, not recruiting Not applicable Interventional

Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention

NCT05027789
View directory record Official record
Conditions
Memory Disorders, Cognitive Impairment
Interventions
Self-Guided, Structured Group
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
65 Years to 90 Years
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Sep 10, 2026, 4:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory

NCT06523218
View directory record Official record
Conditions
Cognitive Decline, Cognitive Function
Interventions
MindMD Supplement, Placebo
Dietary Supplement · Other
Lead sponsor
Scale Media Inc
Industry
Eligibility
50 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2024 · Synced Sep 10, 2026, 4:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Transcranial Magnetic Stimulation on Memory

NCT00105118
View directory record Official record
Conditions
Healthy, Healthy Volunteer, HV
Interventions
Magstim Super Rapid Magnetic Stimulator
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA)

NCT02817061
View directory record Official record
Conditions
Disease Type and/or Category Not Applicable
Interventions
Omnilux
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Characterizing and Predicting Drug Effects on Cognition

NCT01889602
View directory record Official record
Conditions
Cognitive Deficits
Interventions
Lorazepam, Placebo, Topiramate 100mg, Topiramate 150mg, Topiramate 200mg
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 10, 2026, 4:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Blood Flow in the Brain

NCT00466934
View directory record Official record
Conditions
Traumatic Brain Injury, Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 10, 2026, 4:19 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Studies of Blood Flow to the Brain During Thought

NCT00001360
View directory record Official record
Conditions
Healthy Volunteer
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
4,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1993
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 10, 2026, 4:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study

NCT07151235
View directory record Official record
Conditions
Healthy Participants
Interventions
Simulated wildfire smoke exposure, Clean Air exposure
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 40 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 10, 2026, 4:19 AM EDT