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Showing 1–24 of 277 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Healthy Cognition Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease

NCT02380573
View directory record Official record
Conditions
Mild Cognitive Impairment, MCI, Aging, Alzheimer's Disease, AD
Interventions
Methylene Blue, FD&C Blue # 2, Phenazopyridine hydrochloride
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
45 Years to 89 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 24, 2026, 4:00 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Music and Visual Arts Digital Intervention in Teenagers to Promote Healthy Engagement With Social Media.

NCT06402253
View directory record Official record
Conditions
Healthy Subjects, Mental Health Issue
Interventions
Music composition / edition, Photography composition / edition
Behavioral
Lead sponsor
New York University
Other
Eligibility
13 Years to 16 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Synaquell on Brain Function

NCT05041192
View directory record Official record
Conditions
Healthy
Interventions
Synaquell, Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 21 Years · Male only
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 28, 2022 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Direct Current Brain Stimulation on Cognition

NCT00048698
View directory record Official record
Conditions
Electrical Stimulation of the Brain
Interventions
TMS, EEG
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects

NCT02840279
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
BPN14770, Placebo
Drug
Lead sponsor
Tetra Discovery Partners
Industry
Eligibility
25 Years to 90 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Kalamazoo, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Applied Cognition Benchmarking Study

NCT06222385
View directory record Official record
Conditions
Healthy
Interventions
Device measurements during overnight sleep and morning wake, Device measurements during overnight wake and morning sleep
Diagnostic Test
Lead sponsor
Applied Cognition
Industry
Eligibility
55 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
The Villages, Florida
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Synaquell™ in Contact Sport Athletes

NCT06104670
View directory record Official record
Conditions
Healthy
Interventions
Synaquell(TM), Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 19 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 24, 2026, 4:00 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neuropsychiatric Evaluation of Healthy Volunteers and Adults With Schizophrenia

NCT00001323
View directory record Official record
Conditions
Brain Injury, Dementia, Healthy, Mental Disorder, Schizophrenia
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
810 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Working Memory Maintenance (Expt 2.3)

NCT06733467
View directory record Official record
Conditions
Basic Science: Visual Attention in Healthy Participants, Basic Science: Neural Representations of Location
Interventions
Stimulus properties: remembered feature
Other
Lead sponsor
University of California, Santa Barbara
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain and Cognitive Changes After Reasoning or Physical Training in Cognitively Normal Seniors

NCT00977418
View directory record Official record
Conditions
Hearing Impaired
Interventions
SMART- Strategic Memory and Reasoning Training, Physical Exercise
Behavioral · Other
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
60 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2016 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Berry Intake on Metabolic Control and Cognitive Function

NCT03879213
View directory record Official record
Conditions
Healthy
Interventions
Active breakfast, Control breakfast
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
55 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Jul 24, 2026, 4:00 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

NCT00004571
View directory record Official record
Conditions
Schizophrenia, Normal Physiology
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 120 Years
Enrollment
3,273 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Behavioral Differences in Effortful Control

NCT01852344
View directory record Official record
Conditions
Healthy
Interventions
Methylphenidate, Placebo, Easy Behavioral Task, Hard Behavioral Task
Drug · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 35 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 7, 2018 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Self-regulation of Prefrontal Cortex During Emotional Cognitive Control

NCT04543500
View directory record Official record
Conditions
Healthy Volunteers, Cognitive Function
Interventions
Real-time functional magnetic resonance neurofeedback (rtfMRI-nf)
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Jul 24, 2026, 4:00 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Can Cranberry Juice Enhance the Cognition Accuracy and Alleviate Negative Mental Consequences During Multitasking?

NCT06066619
View directory record Official record
Conditions
Stress Response, Multitasking Behavior, Mental Stress, Physiological Stress, Cognitive Symptom, Motor Activity
Interventions
Cranberry Juice A, Cranberry Juice B, Placebo Juice
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
30 Years to 55 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Jul 24, 2026, 4:00 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Lutein, Zeaxathin, and Fish Oil Supplementation

NCT06489873
View directory record Official record
Conditions
Cognitive Performance, Age-Related Macular Degeneration, Bone Loss
Interventions
Active Comparator (Lutein, zeaxanthin, and fish oil supplement (LZF), Placebo Comparator
Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Jul 24, 2026, 4:00 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers

NCT07220265
View directory record Official record
Conditions
Carrier of Phenylketonuria, Healthy
Interventions
Phenylalanine (Phe), Placebo
Dietary Supplement
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine)

NCT00988624
View directory record Official record
Conditions
Alzheimer's Disease, Huntington Disease
Interventions
Dimebon IR Tablet, Dimebon MR1, Dimebon MR2, Dimebon MR3, Dimebon MR4
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Jul 24, 2026, 4:00 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers Results available

A Study of LY2599666 in Healthy Participants and Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD)

NCT02614131
View directory record Official record
Conditions
Healthy, Alzheimer's Disease, Mild Cognitive Impairment
Interventions
LY2599666, Solanezumab, Placebo SC, Placebo IV
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
20 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
3
States / cities
Glendale, California • Marlton, New Jersey • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease

NCT04299308
View directory record Official record
Conditions
Healthy Aging, Alzheimer Disease
Interventions
Aerobic Exercise
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Investigate the Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-D4010 in Healthy Subjects

NCT03031574
View directory record Official record
Conditions
Cognitive Disorder
Interventions
SUVN-D4010
Drug
Lead sponsor
Suven Life Sciences Limited
Industry
Eligibility
18 Years to 80 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lenexa, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 24, 2017 · Synced Jul 24, 2026, 4:00 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of the Healthy Lifestyle Program on Cognitive Outcomes

NCT03926481
View directory record Official record
Conditions
Obesity
Interventions
Evaluate Healthy Lifestyle Program on cognitive outcomes
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
65 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Jul 24, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Stimulation Study

NCT02067689
View directory record Official record
Conditions
Healthy
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Jul 24, 2026, 4:00 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Development of Categorization

NCT00001950
View directory record Official record
Conditions
Cognition Disorder, Healthy
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
1 Year to 3 Years
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Jul 24, 2026, 4:00 PM EDT