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ClinicalTrials.gov public records Last synced Oct 2, 2026, 7:42 PM EDT

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Showing 25–48 of 89 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Healthy Gut Microbiota Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Lentils and Chickpeas on Gut Microbiome and Metabolic Health

NCT06914375
View directory record Official record
Conditions
Dysbiosis
Interventions
Goya Foods - Canned Chickpeas, Goya Foods - Canned Lentils, Control
Other
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 2, 2026, 7:42 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults

NCT05387876
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Vitamin D intervention, Placebo intervention
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 79 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Oct 2, 2026, 7:42 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

The Healthy Diet and Lifestyle Study II

NCT05132686
View directory record Official record
Conditions
Intra-Abdominal Fat
Interventions
IER+MED, MED/DER
Behavioral
Lead sponsor
University of Hawaii
Other
Eligibility
35 Years to 69 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gut Microbial Metabolites of Apple Polyphenols

NCT06107192
View directory record Official record
Conditions
Healthy, Controlled Feeding Trial
Interventions
Dietary intervention - apple catechin diet, Dietary intervention - low catechin diet
Other
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 45 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Two Different Lion's Mane Extracts (Lions Mane Fruiting Body & Lions Mane Fruiting Body With Mycellium) on Cognitive Performance, Subjective Affect, Serum Biomarkers, and Gut Microbiota in Healthy Adults

NCT07405957
View directory record Official record
Conditions
Healthy Adult Females, Healthy Adult Male
Interventions
Lion Mane (Hericium erinaceus) fruiting body extract - Nordic Origin, Lions Mane (Hericium erinaceus) Fruiting body and mycelium, Maltodextrin (Placebo)
Dietary Supplement · Other
Lead sponsor
Applied Food Sciences Inc.
Industry
Eligibility
40 Years to 65 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Dietary Milk Polar Lipids on Serum Cholesterol and Gut Microbiota in Healthy Adults

NCT04208815
View directory record Official record
Conditions
Serum Cholesterol, Gut Microbiome
Interventions
Milk Polar Lipids, Milk Fat
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 50 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Oct 2, 2026, 7:42 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile

NCT06313580
View directory record Official record
Conditions
Cardiometabolic Syndrome
Interventions
Yogurt with added Spices, Yogurt without added Spices
Other
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
50 Years to 69 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota

NCT01473368
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Saccharomyces boulardii, Amoxicillin Clavulanate
Dietary Supplement · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of a Novel Nutritional Product on Nutrient Gaps and Gut Health in Adults With Occasional Gastrointestinal Issues

NCT06564285
View directory record Official record
Conditions
Gastrointestinal Microbiome, Nutrition, Healthy
Interventions
AG1 - Nutritional Supplement, Placebo
Dietary Supplement
Lead sponsor
Athletic Greens International
Industry
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Phase 1 Interventional Results available

Effect of Bismuth Subsalicylate on the Gut Microbiome and Host Response in Healthy Adults

NCT05930197
View directory record Official record
Conditions
Healthy Adults
Interventions
Bismuth subsalicylate
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 50 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Red Raspberry Polyphenols on Gut Microbiome

NCT03049631
View directory record Official record
Conditions
Healthy Subjects, Pre-diabetes
Interventions
Raspberry and fructooligosaccharide, Raspberry
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional

The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients

NCT04111471
View directory record Official record
Conditions
Microbial Colonization
Interventions
Prebiotics, Placebos
Dietary Supplement
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
2 Years to 18 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Oct 2, 2026, 7:42 PM EDT
Not listed No phase listed Observational

The Association of Microbiome Patterns With Chronic Opioid Use

NCT05304403
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Almonds: Digestive Health and Immune Function of Adults and Children

NCT01973595
View directory record Official record
Conditions
Healthy
Interventions
Almonds, Then no almonds, No Almonds, Then almonds
Dietary Supplement · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 26, 2016 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Influence of Diet on GI Health

NCT04783142
View directory record Official record
Conditions
Healthy
Interventions
High-fiber, low-protein diet, Low-fiber, high-protein diet
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 15, 2023 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Impact of Proton Pump Inhibitors on the Fecal Microbiome

NCT01822977
View directory record Official record
Conditions
Healthy, Clostridium Difficile Infection
Interventions
omeprazole
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Oct 2, 2026, 7:42 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Berries, Inflammation, and Gut Microbiome

NCT04100200
View directory record Official record
Conditions
Overweight or Obesity, Healthy
Interventions
Mixed berries, FOS, Control, Combination
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 60 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of a Novel Nutritional Product on Nutrient Status and Digestive Health

NCT06181214
View directory record Official record
Conditions
Gastrointestinal Microbiome, Nutrition, Healthy, Healthy Aging
Interventions
AG1 - Nutritional Supplement, Placebo
Dietary Supplement
Lead sponsor
Athletic Greens International
Industry
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 22, 2024 · Synced Oct 2, 2026, 7:42 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Personalized Responses to Dietary Composition Trial 3

NCT04735835
View directory record Official record
Conditions
Diabetes, Heart Diseases, Diet Habit, Diet Modification, Healthy, Obesity, Metabolism, Microbial Colonization
Interventions
Dietary Intervention
Other
Lead sponsor
Zoe Global Limited
Other
Eligibility
18 Years and older
Enrollment
250,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2030
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 2, 2026, 7:42 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Synbiotic Dietary Supplement and Gut Microbiota

NCT04097106
View directory record Official record
Conditions
Healthy
Interventions
Synbiotic
Dietary Supplement
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 45 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Oct 2, 2026, 7:42 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles

NCT07844616
View directory record Official record
Conditions
Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome, Healthy Adult Participants
Interventions
Egg whites, Whole eggs
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 50 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ButyraGen™, Short Chain Fatty Acids and Gut Microbiome

NCT05601635
View directory record Official record
Conditions
Healthy
Interventions
ButyraGen™
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Assess the Effect of Increasing Intake Amounts of Two Novel Glycans on the Gut Microbiota of Healthy Subjects

NCT04619875
View directory record Official record
Conditions
Healthy
Interventions
KB5, SG1, Lactulose
Other
Lead sponsor
Kaleido Biosciences
Industry
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 6, 2020 · Synced Oct 2, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Human Gut Microbiota and Prebiotic Response

NCT03595306
View directory record Official record
Conditions
Healthy Gut Microbiota
Interventions
Prebiotic A - inulin, Prebiotic B - galactooligosaccharides(GOS), Prebiotic C - wheat dextrin
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
17 Years to 70 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Oct 2, 2026, 7:42 PM EDT