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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Healthy Gut Microbiota Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults

NCT05387876
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Vitamin D intervention, Placebo intervention
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 79 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated May 23, 2022 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota

NCT01473368
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Saccharomyces boulardii, Amoxicillin Clavulanate
Dietary Supplement · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Jul 23, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

iVS-1 Probiotic Intervention Targeting Biological Aging in Midlife Adults

NCT07407894
View directory record Official record
Conditions
Healthy Aging, Anti Aging
Interventions
Bifidobacterium adolescentis iVS-1, Placebo
Dietary Supplement
Lead sponsor
Synbiotic Health
Industry
Eligibility
40 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Port Richey, Florida
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jul 23, 2026, 4:26 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Roles of Gut Microbiome in UTI Susceptible Women

NCT05065008
View directory record Official record
Conditions
Healthy
Interventions
Cranberry juice, Apple juice
Other
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 65 Years · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 23, 2026, 4:26 PM EDT
Completed No phase listed Observational

Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot Study

NCT03152760
View directory record Official record
Conditions
Alcoholism
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Satiety, Glycemic, and Gastrointestinal Effects of Novel Fibers

NCT00958399
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Resistant Starch, Resistant starch + soluble fiber, Fiber made from corn starch, Fiber made from corn starch + soluble fiber
Dietary Supplement
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 5, 2012 · Synced Jul 23, 2026, 4:26 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Synbiotic Dietary Supplement and Gut Microbiota

NCT04097106
View directory record Official record
Conditions
Healthy
Interventions
Synbiotic
Dietary Supplement
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 45 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Dietary Milk Polar Lipids on Serum Cholesterol and Gut Microbiota in Healthy Adults

NCT04208815
View directory record Official record
Conditions
Serum Cholesterol, Gut Microbiome
Interventions
Milk Polar Lipids, Milk Fat
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 50 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 12, 2022 · Synced Jul 23, 2026, 4:26 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance

NCT06795425
View directory record Official record
Conditions
Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness, Immune Function, Gut Health, Microbiome Analysis, Exercise Performance, Exercise Metabolism
Interventions
Postbiotic Active Lifestyle Blend, Placebo
Dietary Supplement · Other
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics (L. Gasseri, B. Bifidum, B. Longum) on Immune and Intestinal Health in Healthy Older Adults

NCT01662206
View directory record Official record
Conditions
Healthy
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 16, 2013 · Synced Jul 23, 2026, 4:26 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers Results available

Xanthohumol Metabolism and Signature

NCT03735420
View directory record Official record
Conditions
Healthy
Interventions
Xanthohumol, Placebo oral capsule
Drug
Lead sponsor
National University of Natural Medicine
Other
Eligibility
21 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Jul 23, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Kimchi and Gut Health

NCT07435831
View directory record Official record
Conditions
Healthy Adult Participants
Interventions
60 grams per day of intervention food
Other
Lead sponsor
University of California, Davis
Other
Eligibility
19 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
2
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 23, 2026, 4:26 PM EDT
Not listed No phase listed Observational

The Association of Microbiome Patterns With Chronic Opioid Use

NCT05304403
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protein-Prebiotic Wellbeing Study

NCT05303753
View directory record Official record
Conditions
Digestive Health, Quality of Life
Interventions
fermented dairy protein with prebiotic fiber
Other
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 35 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Impact of Proton Pump Inhibitors on the Fecal Microbiome

NCT01822977
View directory record Official record
Conditions
Healthy, Clostridium Difficile Infection
Interventions
omeprazole
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Changes to Skin Microbiome With Tape-Stripped Wounds

NCT03365934
View directory record Official record
Conditions
Healthy Volunteers
Interventions
ADHESIVE BANDAGE #1, ADHESIVE BANDAGE #2, ADHESIVE BANDAGE #3, Antibacterial Bandage with 0.8% BZK, Intact and No Bandage, Wounded and No Bandage
Device · Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Fair Lawn, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Jul 23, 2026, 4:26 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults

NCT06873204
View directory record Official record
Conditions
Healthy
Interventions
Soluble Arabinoxylan, Rice Bran, Maltodextrin (Placebo)
Dietary Supplement
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 28, 2025 · Synced Jul 23, 2026, 4:26 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pediatric Microbiome Study With Children Now Approximately 8-10 Years Old.

NCT03485755
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Not listed
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
8 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Skillman, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Synbiotic on the Gut Microbiota and Adiposity-related Markers in Healthy Overweight Subjects

NCT02151825
View directory record Official record
Conditions
Gut Microbiota, Adiposity
Interventions
Synbiotic, Placebo
Dietary Supplement · Other
Lead sponsor
Texas State University, San Marcos
Other
Eligibility
18 Years to 64 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Marcos, Texas
Source: ClinicalTrials.gov public record
Updated May 29, 2014 · Synced Jul 23, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Health Properties of Pecan Nut Consumption

NCT07227259
View directory record Official record
Conditions
Healthy Adults
Interventions
pecan nut
Other
Lead sponsor
University of California, Davis
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Jul 23, 2026, 4:26 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile

NCT06313580
View directory record Official record
Conditions
Cardiometabolic Syndrome
Interventions
Yogurt with added Spices, Yogurt without added Spices
Other
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
50 Years to 69 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of Crofelemer on the Gut Microbiome in Healthy Volunteers and in HIV+ Patients With Non-Infectious Diarrhea

NCT04192487
View directory record Official record
Conditions
Acquired Immunodeficiency Syndrome, Healthy Volunteers, HIV/AIDS, HIV Diarrhea, Human Immunodeficiency Virus
Interventions
Crofelemer delayed-release tablets 125mg
Drug
Lead sponsor
Napo Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
3
States / cities
Tustin, California • Stratford, Connecticut • Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2021 · Synced Jul 23, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Resistant Maltodextrin Supplementation: Gastrointestinal Health

NCT02733263
View directory record Official record
Conditions
Healthy
Interventions
15 g RMD, 25 g RMD, 0 g RMD
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 1, 2018 · Synced Jul 23, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Native Chicory Inulin on Change and Persistence of Gut Microbiota

NCT06528041
View directory record Official record
Conditions
Healthy
Interventions
Inulin, Maltodextrin
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 45 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Jul 23, 2026, 4:26 PM EDT