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Showing 1–24 of 296 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Heat Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cooling Vest May Reduce Heat Stress During Surgery

NCT04511208
View directory record Official record
Conditions
Body Temperature Changes
Interventions
Cooling Vest, Without cooling vest
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
25 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 27, 2022 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Phase 3 Interventional

A Study of Tanespimycin (KOS-953) in Patients With Multiple Myeloma in First Relapse

NCT00546780
View directory record Official record
Conditions
Multiple Myeloma
Interventions
Tanespimycin, Bortezomib
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
18
States / cities
Bakersfield, California • La Jolla, California • San Francisco, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2011 · Synced Sep 4, 2026, 5:42 AM EDT
Terminated Not applicable Interventional Results available

A Study to Evaluate Cutaneous Scar Quality Following Bilateral Breast Reduction With the PEAK PlasmaBlade 4.0

NCT01284491
View directory record Official record
Conditions
Macromastia
Interventions
PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
Device
Lead sponsor
Medtronic Surgical Technologies
Industry
Eligibility
18 Years to 70 Years · Female only
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2013 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Phase 1 Interventional Results available

A Phase 1 Study of HS130 in Combination With Viagenpumatucel-L (HS110) in Patients With Solid Tumors

NCT04116710
View directory record Official record
Conditions
Advanced Solid Tumor
Interventions
HS-110 (viagenpumatucel-L), HS-130
Biological
Lead sponsor
Heat Biologics
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Leg Heat Therapy in Elderly Individuals

NCT05543980
View directory record Official record
Conditions
Aging, Muscle Weakness
Interventions
Sham device, Leg heat therapy device
Device
Lead sponsor
Purdue University
Other
Eligibility
65 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial

NCT05666713
View directory record Official record
Conditions
Valvular Heart Disease, Aortic Valve Failure
Interventions
TELLTALE BASILICA procedure
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years to 109 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
10
States / cities
San Francisco, California • Fort Collins, Colorado • Washington D.C., District of Columbia + 7 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Sep 4, 2026, 5:42 AM EDT
Recruiting Early Phase 1 Interventional

The Hysterosalpingogram (HSG) Experience And Tubal Spasm (HEAT) Study

NCT07226310
View directory record Official record
Conditions
Infertility
Interventions
Warmed HSG
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 4, 2026, 5:42 AM EDT
Recruiting Not applicable Interventional

Researching Heat and Yoga for Mood Enhancement

NCT06094088
View directory record Official record
Conditions
Depression
Interventions
Heated Yoga, Non-Heated Yoga
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Quantitative Heat Loss With Laminar Air Flow

NCT01564212
View directory record Official record
Conditions
Healthy
Interventions
standard airflow with forced air warming., laminar airflow with surgical drapes, laminar airflow with forced air warming, standard airflow with surgical drapes
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 45 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional

S&B Heat Stress Pilot Protocols

NCT06094764
View directory record Official record
Conditions
Thermal Discomfort
Interventions
Group A, Group B
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2023 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Fatigue in Varying Hot Environments

NCT04624919
View directory record Official record
Conditions
Hyperthermia
Interventions
Hot/Dry, Warm/Humid
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 39 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Renal Considerations in the Heat Stress Recommendations (Aim2)

NCT05458843
View directory record Official record
Conditions
Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia, Dehydration
Interventions
Fluid replacement, No fluid replacement
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 44 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Abuse Liability Among African American and White Smokers

NCT04646668
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
E-cigarette and Heat not burn
Combination Product
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Sep 4, 2026, 5:42 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults

NCT03038243
View directory record Official record
Conditions
Shigella Sonnei Dysenteries
Interventions
Shigella flexneri 2a whole cell (Sf2aWC) vaccine and double mutant E. coli heat labile toxin (dmLT), Shigella flexneri 2a whole cell (Sf2aWC) vaccine, Placebo
Biological · Other
Lead sponsor
PATH
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2017 · Synced Sep 4, 2026, 5:42 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting.

NCT07564440
View directory record Official record
Conditions
Safety Study
Interventions
Hyperthermia
Other
Lead sponsor
Marc Abreu
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 4, 2026, 5:42 AM EDT
Recruiting Phase 2 Interventional

Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria

NCT06865651
View directory record Official record
Conditions
Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)
Interventions
Remibrutinib, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
North Miami Beach, Florida • Glenview, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Skin Surface and Intradermal Temperature Responses to Heat Stress

NCT06593067
View directory record Official record
Conditions
Hyperthermia
Interventions
Control, Fan, Fan and Water Spray, Water Spray
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 4, 2026, 5:42 AM EDT
Enrolling by invitation Not applicable Interventional

Feasibility of Improving Glycemia With Heat Therapy to Prevent AD

NCT06023407
View directory record Official record
Conditions
Healthy Aging, Alzheimer Disease, Metabolic Disease
Interventions
Water Immersion Heat Therapy
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 4, 2026, 5:42 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

The Role of Carbohydrate Blends and Electrolytes on Physical and Mental Performance During Cycling in the Heat

NCT07658820
View directory record Official record
Conditions
Hydration, Dehydration (Physiology), Performance
Interventions
Water (Placebo), Carbohydrate Milk Permeate sports drink, 6% Sports drink, Low-Carbohydrate Milk Permeate sports drink
Dietary Supplement
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 55 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Early Phase 1 Interventional Results available

Aspirin as a Pre-Treatment for Exercise in Multiple Sclerosis

NCT03051646
View directory record Official record
Conditions
Fatigue, Overheating
Interventions
Acetylsalicylic acid at 1st visit, then Placebo at 2nd visit, Placebo at 1st visit, then Acetylsalicylic acid at 2nd visit
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 4, 2026, 5:42 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Physical Rehabilitation of COVID-19 Survivors by Heat Therapy

NCT04673318
View directory record Official record
Conditions
Covid19, Physical Disability
Interventions
heat therapy, exercise training
Behavioral
Lead sponsor
University of Massachusetts, Amherst
Other
Eligibility
55 Years to 85 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Amherst, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Feasibility of Rice Bran Supplementation in Nicaraguan Children

NCT02615886
View directory record Official record
Conditions
Dietary Rice Bran Supplementation
Interventions
Observational Control, Rice bran
Other · Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
4 Months to 13 Months
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 18, 2017 · Synced Sep 4, 2026, 5:42 AM EDT
Completed Phase 2 Interventional

Heat Therapy in Treating Patients With Unresectable Primary or Metastatic Liver Cancer

NCT00004136
View directory record Official record
Conditions
Liver Cancer, Metastatic Cancer
Interventions
Radiofrequency Ablation
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Not listed
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2006
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 5, 2018 · Synced Sep 4, 2026, 5:42 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Testing A Visual Thermometer in Newborns and Young Infants

NCT05609292
View directory record Official record
Conditions
Hyperthermia, Hypothermia
Interventions
observational
Device
Lead sponsor
University of Minnesota
Other
Eligibility
0 Months to 6 Months
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 4, 2026, 5:42 AM EDT