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ClinicalTrials.gov public records Last synced Oct 19, 2026, 7:37 PM EDT

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Showing 145–168 of 298 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Heat Clear all
Withdrawn Not applicable Interventional

Working Toward the Advancement of Recovery Using Modulated Therapeutic Hyperthermia (WARMTH) in Sepsis - Pilot

NCT04961151
View directory record Official record
Conditions
Sepsis
Interventions
Multimodal therapeutic warming w/ esophageal d/c, Multimodal therapeutic warming w/ conductive d/c
Other
Lead sponsor
Nicholas M Mohr
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Iowa City, Iowa • Minneapolis, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Neck Cooling Collar on Exercise Performance in the Heat

NCT05135117
View directory record Official record
Conditions
Hyperthermia
Interventions
NeuroRescue Cooling Collar, Ice Towel
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Safety, Reactogenicity and Immunogenicity of Fractional-dose Inactivated Polio Vaccine (fIPV) Given Intradermally With Double Mutant Enterotoxigenic Escherichia Coli Heat Labile Toxin (dmLT) Adjuvant

NCT03922061
View directory record Official record
Conditions
Polio
Interventions
dmLT, fIPV
Biological
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 45 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Oct 19, 2026, 7:37 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Identification of Critical Thermal Environments for Aged Adults

NCT04284397
View directory record Official record
Conditions
Aging
Interventions
Low dose ASA, Control
Drug · Other
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Not applicable Interventional Results available

NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial

NCT05666713
View directory record Official record
Conditions
Valvular Heart Disease, Aortic Valve Failure
Interventions
TELLTALE BASILICA procedure
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years to 109 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
10
States / cities
San Francisco, California • Fort Collins, Colorado • Washington D.C., District of Columbia + 7 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1 Interventional Results available

A Phase 1 Study of HS130 in Combination With Viagenpumatucel-L (HS110) in Patients With Solid Tumors

NCT04116710
View directory record Official record
Conditions
Advanced Solid Tumor
Interventions
HS-110 (viagenpumatucel-L), HS-130
Biological
Lead sponsor
Heat Biologics
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Sauna Detoxification Study: Pilot Feasibility

NCT01576822
View directory record Official record
Conditions
Hyperthermia
Interventions
This protocol will utilize a sauna as the primary method of detoxification.
Other
Lead sponsor
Bastyr University
Other
Eligibility
21 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Kenmore, Washington
Source: ClinicalTrials.gov public record
Updated Oct 30, 2012 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1 Interventional

Safety Study of an Antisense Product in Prostate, Ovarian, NSCL, Breast or Bladder Cancer

NCT00487786
View directory record Official record
Conditions
Neoplasms
Interventions
OGX-427, Docetaxel
Drug
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 18, 2016 · Synced Oct 19, 2026, 7:37 PM EDT
Terminated Phase 2 Interventional Results available

Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

NCT01814813
View directory record Official record
Conditions
Recurrent Glioblastoma, Recurrent Adult Brain Tumor, Gliosarcoma
Interventions
HSPPC-96, bevacizumab
Biological · Drug
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
417
States / cities
Anchorage, Alaska • Hot Springs, Arkansas • Little Rock, Arkansas + 268 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1 Interventional Results available

Cancer Vaccine Targeting Brachyury Protein in Tumors

NCT01519817
View directory record Official record
Conditions
Neoplasms, Malignant Solid Tumors, Colon Neoplasms, Adenocarcinoma
Interventions
GI-6301 (Yeast Brachyury Vaccine)
Biological
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 100 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 29, 2018 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1Phase 2 Interventional

Vaccination of Patients With Stage IV Melanoma With Dendritic Cells

NCT00125749
View directory record Official record
Conditions
Melanoma, Neoplasm Metastasis
Interventions
Dendritic cell vaccination
Biological
Lead sponsor
Baylor Research Institute
Other
Eligibility
21 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 19, 2026, 7:37 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults

NCT03038243
View directory record Official record
Conditions
Shigella Sonnei Dysenteries
Interventions
Shigella flexneri 2a whole cell (Sf2aWC) vaccine and double mutant E. coli heat labile toxin (dmLT), Shigella flexneri 2a whole cell (Sf2aWC) vaccine, Placebo
Biological · Other
Lead sponsor
PATH
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 20, 2017 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults

NCT04026126
View directory record Official record
Conditions
Heart Failure, Heart Diseases, Cardiovascular Diseases, Endothelial Dysfunction
Interventions
Heat Therapy Treatment
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
50 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tarp Assisted Cooling of Hyperthermic Individuals

NCT04095403
View directory record Official record
Conditions
Healthy
Interventions
Tarp Assisted Cooling, passive cooling
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 39 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1 Interventional

A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver

NCT00001576
View directory record Official record
Conditions
Colorectal Neoplasm, Liver Neoplasm, Neoplasm Metastasis
Interventions
Melphalan, Floxuridine, Leucovorin
Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
Not listed
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 19, 2026, 7:37 PM EDT
Recruiting No phase listed Observational

Genetic Risk Factor for Heat Stroke

NCT06847256
View directory record Official record
Conditions
Carrier State, Heat Stroke, Dehydration
Interventions
Heat Challenge
Procedure
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 19, 2026, 7:37 PM EDT
Not listed Phase 1Phase 2 Interventional

Safety and Feasibility Study of Targeted Temperature Management After ICH

NCT01607151
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
Normothermia, Hypothermia
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2015 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Experimental and Commercial Air-Activated, Adhesive Backed Heat Patches

NCT01841801
View directory record Official record
Conditions
Effects of Heat, Tolerability, Adhesiveness, Dermal Irritation
Interventions
Thermal Adhesive Patch, Marketed Thermal Adhesive Patch, Placebo Patch
Device
Lead sponsor
Chattem, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Pinellas Park, Florida
Source: ClinicalTrials.gov public record
Updated Mar 17, 2017 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Not applicable Interventional Results available

A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome

NCT02526277
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
MMF07 Foot Massager, Heat Therapy
Device
Lead sponsor
Ariane Park
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cooling Strategies for Older Adults in the Heat

NCT06349616
View directory record Official record
Conditions
Aging
Interventions
Intermittent cold-water hand and forearm immersion, No intermittent cold-water hand and forearm immersion
Other
Lead sponsor
Penn State University
Other
Eligibility
65 Years to 100 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Oct 19, 2026, 7:37 PM EDT
Terminated Phase 2 Interventional Results available

A Phase 2 Study of Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer

NCT02117024
View directory record Official record
Conditions
Non Small Cell Lung Cancer
Interventions
Viagenpumatucel-L, Metronomic Cyclophosphamide, Physician's Choice Regimen (Vinorelbine, Erlotinib, Gemcitabine, Paclitaxel, Docetaxel, Pemetrexed)
Drug
Lead sponsor
Heat Biologics
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
16
States / cities
Rogers, Arkansas • La Jolla, California • Los Angeles, California + 13 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 19, 2026, 7:37 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Apply the PD Model of Peripheral Oxytocin Action to a Multimodal Stimulus

NCT04433741
View directory record Official record
Conditions
Pain, Chronic
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 26, 2024 · Synced Oct 19, 2026, 7:37 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Peanut Allergy Vaccine Study in Healthy and Peanut-allergic Adults

NCT00850668
View directory record Official record
Conditions
Food Hypersensitivity, Hypersensitivity, Immediate Hypersensitivity, Peanut Hypersensitivity
Interventions
E. Coli-Encapsulated, Recombinant Modified Peanut Proteins Ara h 1, Ara h 2, and Ara h 3
Biological
Lead sponsor
Allertein Therapeutics, LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
Baltimore, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2013 · Synced Oct 19, 2026, 7:37 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TENS and Heat for Reducing Back Pain in Humans

NCT03740750
View directory record Official record
Conditions
Pain
Interventions
Thermacare heat wraps, TENS, sham heat, sham Tens
Device
Lead sponsor
Future Sciene Technology
Industry
Eligibility
24 Years to 60 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Henderson, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Oct 19, 2026, 7:37 PM EDT