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Showing 1–24 of 298 matching trials from the live ClinicalTrials.gov search.
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Two Different Methods to Prescribe Exercise

NCT04286919
Conditions
Physical Activity, Health Behavior
Interventions
A Randomized Controlled Trial Comparing the Physical Activity Guidelines for Americans to a New Method of Exercise Prescription Among College Students
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Storrs, Connecticut
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity

NCT00947284
Conditions
Healthy
Interventions
nalbuphine plus naloxone, nalbuphine plus saline, naloxone plus saline
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 40 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
San Francisco, California
Conditions
Healthy Adults
Interventions
RSB11-HI Heat-Inactivated Postbiotic, Placebo
Dietary Supplement · Other
Lead sponsor
Able Biolabs, LLC
Other
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Advanced Breast Cancer, Treatment-Refractory Solid Tumors, Retinoblastoma Deficiency, SCLC, Soft Tissue Sarcoma, Endometrial Cancer, Bladder Cancer
Interventions
Palbociclib Oral Product, TAS-116
Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults

NCT06842784
Conditions
Aging, Heat Stress, Hyperthermia, Heat Strain
Interventions
Ambient heat stress
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Completed Not applicable Interventional Accepts healthy volunteers

Cold Water Immersion Stirring in Hyperthermic Individuals

NCT04613843
Conditions
Hyperthermia
Interventions
Water Stirring, No Water Stirring
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 39 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Recruiting Not applicable Interventional Accepts healthy volunteers

Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

NCT05303415
Conditions
Pain
Interventions
Neuromodulation with low-intensity focused ultrasound
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Completed Not applicable Interventional Accepts healthy volunteers

Impact of ICE on Exercise Performance in the Heat

NCT04596618
Conditions
Hyperthermia
Interventions
Forearm cooling
Device
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Storrs, Connecticut
Conditions
Tendon Injuries, Musculoskeletal Pain
Interventions
Therapeutic ultrasound, Placebo therapeutic ultrasound
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Milford, Connecticut • Trumbull, Connecticut
Recruiting Not applicable Interventional

Beat the Heat Boston

NCT06982339
Conditions
Hot Weather; Adverse Effect, Heat Effect, Heat Stress, Heat Stroke, Heat Exhaustion, Heat Exposure, Heat Strain
Interventions
Air Conditioner, Electricity subsidy
Other
Lead sponsor
Harvard School of Public Health (HSPH)
Other
Eligibility
55 Years to 95 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Breast Cancer
Interventions
PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
Device · Procedure
Lead sponsor
Medtronic Surgical Technologies
Industry
Eligibility
18 Years to 90 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Mountain View, California
Conditions
Major Depressive Disorder
Interventions
Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia
Behavioral · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
San Francisco, California • Boston, Massachusetts • Cleveland, Ohio
Conditions
Topical Heat Application for Intraoperative Abortion Pain Management
Interventions
heat
Other
Lead sponsor
Planned Parenthood of Greater New York
Other
Eligibility
16 Years to 51 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Brooklyn, New York
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetic Study of Synera in Healthy Volunteers

NCT01602757
Conditions
Healthy
Interventions
Synera
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Fargo, North Dakota
Conditions
Bladder Cancer
Interventions
HS-410, Placebo, BCG
Biological
Lead sponsor
Heat Biologics
Industry
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
19
States / cities
Los Angeles, California • Sherman Oaks, California • Torrance, California + 16 more
Completed Phase 1 Interventional Accepts healthy volunteers

Peanut Allergy Vaccine Study in Healthy and Peanut-allergic Adults

NCT00850668
Conditions
Food Hypersensitivity, Hypersensitivity, Immediate Hypersensitivity, Peanut Hypersensitivity
Interventions
E. Coli-Encapsulated, Recombinant Modified Peanut Proteins Ara h 1, Ara h 2, and Ara h 3
Biological
Lead sponsor
Allertein Therapeutics, LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
Baltimore, Maryland • New York, New York
Conditions
Solid Tumors, Non-small Cell Lung Carcinoma
Interventions
DS-2248
Drug
Lead sponsor
Daiichi Sankyo
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
9
States / cities
Duarte, California • Loma Linda, California • Orange, California + 6 more
Conditions
Hepatocellular Carcinoma, Liver Neoplasms
Interventions
ThermoDox
Drug
Lead sponsor
Imunon
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Manhasset, New York
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Thermodynamic Exposure and Sleep in Military Cadets

NCT07201935
Conditions
Cold-water Immersion, High Heat Sauna, Combination of Cold-water Immersion and High Heat Sauna
Interventions
Cold Water Immersion, High Heat Sauna
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 30 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Completed Not applicable Interventional Results available

Heat Therapy to Reduce Pain and Improve Walking Tolerance

NCT03435835
Conditions
Peripheral Arterial Disease
Interventions
Control/Sham Treatment, Heat Therapy (HT)
Device
Lead sponsor
Indiana University
Other
Eligibility
Not listed
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Subarachnoid Hemorrhage, Subdural Hematoma, Traumatic Brain Injury, Ischemic Stroke, Fever, Intracerebral Hemorrhage
Interventions
Bromocriptine 5 MG, Acetaminophen 650 MG
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 100 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
San Francisco, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aging and Gastrointestinal Barrier Function

NCT05816551
Conditions
Aging, Hyperthermia
Interventions
Hyperthermia Trial, Control Trial
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Laryngeal Cancer, Laryngectomy
Interventions
SpeakFree HME Hands Free Valve, Digital Occlusion, Digital Depression HME
Device · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Miami, Florida
Completed Phase 1 Interventional Accepts healthy volunteers

Safety of Sublingual dmLT for ETEC

NCT02052934
Conditions
Gastroenteritis Escherichia Coli
Interventions
Recombinant Double Mutant Heat-Labile Toxin LT(R192G/L211A) (dmLT) Oral enterotoxigenic Escherichia coli (ETEC) Vaccine
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio