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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Heat Stress Disorders Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Influences of Female Sex and Reproductive Hormones on Physiological Aspects of Heat Acclimation

NCT05292170
View directory record Official record
Conditions
Heat Stress, Exertional
Interventions
Heat acclimation
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 40 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Sep 25, 2026, 11:03 PM EDT
Recruiting Not applicable Interventional

Leg Heat Therapy in Peripheral Artery Disease

NCT05465070
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Leg heat therapy, Sham Control
Device
Lead sponsor
Indiana University
Other
Eligibility
50 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting.

NCT07564440
View directory record Official record
Conditions
Safety Study
Interventions
Hyperthermia
Other
Lead sponsor
Marc Abreu
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Recruiting Not applicable Interventional

The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.

NCT07224464
View directory record Official record
Conditions
Metastatic Solid Tumors, Stage 4 Cancer
Interventions
The Sarah Nanotechnology System - intended to deliver thermal energy to malignant cells for the purpose of thermal destruction of these cells in patients with advanced metastatic solid tumors.
Device
Lead sponsor
New Phase Ltd.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Terminated Not applicable Interventional Results available

PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.

NCT01081886
View directory record Official record
Conditions
Degenerative Joint Disease, Osteoarthritis
Interventions
PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
Device
Lead sponsor
Medtronic Surgical Technologies
Industry
Eligibility
21 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Rochester Hills, Michigan • Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2013 · Synced Sep 25, 2026, 11:03 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Testing A Visual Thermometer in Newborns and Young Infants

NCT05609292
View directory record Official record
Conditions
Hyperthermia, Hypothermia
Interventions
observational
Device
Lead sponsor
University of Minnesota
Other
Eligibility
0 Months to 6 Months
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 25, 2026, 11:03 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

NCT07472426
View directory record Official record
Conditions
Acute Kidney Injury, Exertional Heat Illness
Interventions
Creatine Monohydrate, Maltodextrin (Placebo)
Dietary Supplement
Lead sponsor
University of Northern Iowa
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cedar Falls, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Completed No phase listed Observational

Effects of Monopolar Electrocautery Use During Surgery on Implanted Cardiac Defibrillators

NCT01572246
View directory record Official record
Conditions
Heart Failure, Tachycardia, Ventricular
Interventions
Optimal placement of return pad
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of ICE on Exercise Performance in the Heat

NCT04596618
View directory record Official record
Conditions
Hyperthermia
Interventions
Forearm cooling
Device
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 20, 2020 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Phase 1 Interventional Results available

A New Heat Therapy Device for Home-based Leg Heating in Patients With Lower-extremity Peripheral Artery Disease

NCT05335161
View directory record Official record
Conditions
Peripheral Arterial Disease, Intermittent Claudication
Interventions
Home-based leg heat therapy
Device
Lead sponsor
Purdue University
Other
Eligibility
60 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Multi-Level Approach to Heat-Related Illness Prevention in Agricultural Workers

NCT04234802
View directory record Official record
Conditions
Heat Stress Disorders
Interventions
Heat Education and Awareness Tools
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Yakima, Washington
Source: ClinicalTrials.gov public record
Updated May 16, 2022 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury Risk

NCT06442956
View directory record Official record
Conditions
Occupational Injuries, Heat Stress, Leg Injury, Back Injuries
Interventions
Rapid Heat Condition, Gradual Heat Condition
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 57 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Phase 2Phase 3 Interventional

A Study of Tanespimycin (KOS-953) in Patients With Relapsed-refractory Multiple Myeloma

NCT00514371
View directory record Official record
Conditions
Multiple Myeloma
Interventions
tanespimycin, Bortezomib
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
11
States / cities
Berkeley, California • San Francisco, California • Augusta, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 6, 2015 · Synced Sep 25, 2026, 11:03 PM EDT
Recruiting Phase 1 Interventional

Heat Therapy in Type 2 Diabetes

NCT06596967
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Heat therapy, Sham
Device
Lead sponsor
Purdue University
Other
Eligibility
55 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Heat on Dual Task Performance

NCT07629414
View directory record Official record
Conditions
Healthy, Heat Stress, Exertional
Interventions
heat stress
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 57 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Biomarkers to Assess Acute Kidney Injury Risk During Heat Strain

NCT05710978
View directory record Official record
Conditions
Hyperthermia, Kidney Injury, Acute
Interventions
Work Protocol
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 39 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Nov 12, 2023 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Phase 3 Interventional Results available

Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis

NCT00052962
View directory record Official record
Conditions
Gastrointestinal Neoplasm
Interventions
Cytoreductive surgery, Continuous hyperthermic peritoneal perfusion (HIPEC/CHPP)
Procedure
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 21, 2012 · Synced Sep 25, 2026, 11:03 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Leg Heating in Pregnant Women With Obesity

NCT06932250
View directory record Official record
Conditions
High-risk Pregnancy
Interventions
Leg heating
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional

Cooling Solutions for Outdoor Workers

NCT06998667
View directory record Official record
Conditions
Hyperthermia, Heat Acclimation and Thermotolerance
Interventions
Standard Heat Illness Prevention Measures, Cooling bandana, Cooling glove
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Laparoscopic Cholecystectomy And Capacitive Coupling - Coag Versus Blend Mode Causing Thermal Injury at Port Site Skin

NCT01664806
View directory record Official record
Conditions
Intraoperative Complications, Thermal Injury, Electrocoagulation
Interventions
Covidien Triad monopolar generator
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 24, 2013 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cardiovascular Responses to Heat Waves in the Elderly

NCT04538144
View directory record Official record
Conditions
Aging, Hyperthermia
Interventions
Hot and Humid Trial, Hot and Dry Trial
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Validity of CORE Sensor in Heat Training for Male and Female Endurance Athletes

NCT05692947
View directory record Official record
Conditions
Temperature Change, Body
Interventions
Core body temperature device
Device
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 59 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Early Phase 1 Interventional Results available

Aspirin as a Pre-Treatment for Exercise in Multiple Sclerosis

NCT03051646
View directory record Official record
Conditions
Fatigue, Overheating
Interventions
Acetylsalicylic acid at 1st visit, then Placebo at 2nd visit, Placebo at 1st visit, then Acetylsalicylic acid at 2nd visit
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 25, 2026, 11:03 PM EDT
Completed Not applicable Interventional

Effect of Heat Stress on Global LV Function in Anesthetized Humans

NCT04553900
View directory record Official record
Conditions
Hyperthermia, Cardiac Functional Disturbances During Surgery
Interventions
Transesophageal Echocardiography
Diagnostic Test
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Sep 25, 2026, 11:03 PM EDT