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ClinicalTrials.gov public records Last synced Oct 30, 2026, 1:37 PM EDT

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Showing 1–24 of 72 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Heavy Drinking Behavior Clear all
Recruiting Phase 1 Interventional

Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers

NCT06136195
View directory record Official record
Conditions
Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
Interventions
Mavoglurant
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional

A Web Application to Reduce Heavy Drinking in First-time DWI Offenders

NCT02071836
View directory record Official record
Conditions
Driving While Intoxicated, Driving Under the Influence, Heavy Drinking, Alcohol Abstinence
Interventions
Right Turns web application, Treatment as usual
Behavioral
Lead sponsor
Behavior Therapy Associates, LLP
Industry
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 1, 2017 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Early Phase 1 Interventional

Varenicline + Prazosin for Heavy Drinking Smokers

NCT02193256
View directory record Official record
Conditions
Cigarette Smoking, Alcohol Use Disorders
Interventions
Varenicline, Prazosin, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Phase 2 Interventional

Evaluation of an School-based Alcohol Prevention Program for Middle School Students

NCT01847183
View directory record Official record
Conditions
Alcohol-related Disorders, Drinking and Driving, Neurological Impairment
Interventions
Click City®: Alcohol
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
12 Years to 16 Years
Enrollment
2,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Results available

Internet-based Videoconferencing to Address Alcohol Use and Pain

NCT03982433
View directory record Official record
Conditions
Chronic Pain, Alcohol Use, Unspecified
Interventions
Motivation and Cognitive Behavioral Management for Alcohol and Pain
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 13, 2019 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional

Virtual Reality- Working Memory Retraining

NCT03786276
View directory record Official record
Conditions
Alcohol Use Disorder, Mild Traumatic Brain Injury
Interventions
VR-WMR-Only, Exercise-only, Active VR-WMR
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling

NCT02654236
View directory record Official record
Conditions
Alcohol Consumption
Interventions
Placebo, 10 mg Obeticholic Acid (OCA)
Drug
Lead sponsor
Suthat Liangpunsakul
Other
Eligibility
21 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Phase 4 Interventional

Targeted Naltrexone for Problem Drinkers

NCT00369408
View directory record Official record
Conditions
Alcoholism, Alcohol Drinking, Alcohol Dependence
Interventions
Naltrexone, placebo
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 70 Years
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 20, 2011 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional

Component Analysis for Motivational Interviewing

NCT01642381
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions
Full Motivational Interviewing ("FMI"), Spirit Only Motivational Interviewing ("SOMI")
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 65 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Sep 12, 2016 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Phase 1 Interventional Results available

Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers

NCT03271528
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Lacosamide, Placebo oral capsule
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
21 Years to 55 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 3, 2021 · Synced Oct 30, 2026, 1:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Phosphatidylethanol and Other Ethanol Consumption Markers

NCT06747364
View directory record Official record
Conditions
Healthy Volunteer, Alcohol Consumption
Interventions
Alcohol (Ethanol)
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
21 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Denton, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Behavioral Interventions to Reduce Heavy Drinking Among MSM in HIV Primary Care

NCT02709759
View directory record Official record
Conditions
Alcohol Drinking, HIV
Interventions
Motivational intervention, Brief Advice, Interactive text messaging
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Smoking Tobacco and Drinking Study

NCT03163303
View directory record Official record
Conditions
Smoking, Heavy Episodic Drinking
Interventions
Tobacco Status Project Intervention, Tobacco Status Project + Alcohol Intervention, nicotine patch
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Results available

Effect of Theta Burst Stimulation on Alcohol Cue Reactivity

NCT04223154
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence, Alcohol Abuse
Interventions
Real iTBS to the dlPFC, Sham iTBS to the dlPFC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tailored Mobile Text Messaging to Reduce Problem Drinking

NCT01885312
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions
Adaptive Tailored Intervention, Consequence-based Intervention, Tailored, not adaptive, based Intervention, Assessment only
Behavioral · Other
Lead sponsor
Northwell Health
Other
Eligibility
21 Years to 65 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Results available

Understanding and Intervening With Heavy Drinking Among Patients With HIV and HCV

NCT03652675
View directory record Official record
Conditions
Alcohol Use Disorder, HIV/AIDS, Hepatitis C, Binge Drinking
Interventions
Intervention: (Clinician's Guide + HealthCall for HIV/HCV)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 99 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2021 · Synced Oct 30, 2026, 1:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults

NCT06976528
View directory record Official record
Conditions
Heavy Episodic Drinking
Interventions
Alcohol administration
Other
Lead sponsor
New York University
Other
Eligibility
21 Years to 29 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adolescent Substance Use Prevention Intervention Research Study in Pediatric Primary Care

NCT04450966
View directory record Official record
Conditions
Heavy Drinking, Driving Under the Influence, Riding With Driver Under the Influence
Interventions
Computer-facilitated Screening and Brief Intervention
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
14 Years to 17 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
3
States / cities
Itasca, Illinois • Boston, Massachusetts • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Varenicline to Reduce Alcohol Consumption in Heavy Drinkers

NCT00695500
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Varenicline, Placebo
Drug
Lead sponsor
Vijay Ramchandani, Ph.D.
NIH
Eligibility
21 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 15, 2016 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional

A Brief Intervention for Alcohol Users With Interpersonal Trauma

NCT05414344
View directory record Official record
Conditions
Heavy Drinking, Alcohol Drinking, Substance Use, Drinking Behavior
Interventions
Standard Brief Intervention, Trauma-Informed and Peer-Supported Brief Intervention, Assessment only
Behavioral
Lead sponsor
Western Kentucky University
Other
Eligibility
18 Years to 25 Years
Enrollment
284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 30, 2026, 1:37 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Culturally Adapted Brief Intervention for Heavy Drinking Hispanic Men

NCT02429401
View directory record Official record
Conditions
Alcohol Consumption
Interventions
Non-adapted brief motivational interview, Culturally adapted brief motivational interview
Behavioral
Lead sponsor
University of Texas, El Paso
Other
Eligibility
18 Years and older · Male only
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
2
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alcohol and Sex Risk mHealth-Enhanced Brief Intervention for BLMSM

NCT04821427
View directory record Official record
Conditions
Heavy Drinking and Sexual Risk Behavior
Interventions
Brief mhealth intervention + mobile messaging to reduce sexual risk behavior and heavy drinking
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Not applicable Interventional

Adaptive Interventions for Problem Drinkers

NCT02511808
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions
Brief Advice, Motivational Interviewing, Behavioral Self-Control Training
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 75 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2020 · Synced Oct 30, 2026, 1:37 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking Cessation

NCT02859142
View directory record Official record
Conditions
Smoking Cessation, Alcohol Drinking
Interventions
Chantix, Behavioral Counseling Sessions, NicodermCQ, Placebo
Drug · Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 85 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Oct 30, 2026, 1:37 PM EDT