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ClinicalTrials.gov public records Last synced Nov 11, 2026, 10:42 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 89 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Hernia, Diaphragmatic Clear all

Conditions: GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia, Gastroesophageal Reflux
Interventions: Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry; Procedure
Lead sponsor: McMaster University; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Hiatal Hernia, Interstitial Lung Disease
Interventions: Blood Collection, Bronchoscopy; Diagnostic Test
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Congenital Diaphragmatic Hernias
Interventions: Fetoscopic Endoluminal Tracheal Occlusion (FETO); Device
Lead sponsor: Connecticut Children's Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2030
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Interventions: FETO with GoldBAL2 Balloon and BALTACCIBDPE100 Catheter; Device
Lead sponsor: Holly L Hedrick, MD; Other
Eligibility: 18 Years and older · Female only
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2032
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Gastroesophageal Reflux Disease, Hiatal Hernia
Interventions: TIF Transoral Fundoplication, Sham placebo procedure; Device · Other
Lead sponsor: EndoGastric Solutions; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 9
States / cities: Los Angeles, California • Englewood, Colorado • Chicago, Illinois + 5 more

Conditions: Sepsis, Congenital Diaphragmatic Hernia, Neonatal Cardiopulmonary Failure
Interventions: Not listed
Lead sponsor: University of Utah; Other
Eligibility: Up to 2 Months
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 2
States / cities: Salt Lake City, Utah

Conditions: Diaphragmatic Hernia, Lung Disease
Interventions: Fetal tracheal obstruction with detachable balloon (device); Device
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2015
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Congenital Diaphragmatic Hernia
Interventions: Congenital diaphragmatic hernia resuscitation with an intact umbilical cord; Procedure
Lead sponsor: University of Colorado, Denver; Other
Eligibility: Up to 5 Minutes
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Hiatal Hernia Large, Reflux, Gastroesophageal
Interventions: Hiatal Hernia Repair with Platelet Rich Plasma, Hiatal Hernia Repair without Platelet Rich Plasma; Procedure
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 2
States / cities: Los Angeles, California • Newport Beach, California

Conditions: Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
Interventions: Gore ENFORM Biomaterial (Preperitoneal), Gore ENFORM Biomaterial (Intraperitoneal); Device
Lead sponsor: W.L.Gore & Associates; Industry
Eligibility: 18 Years and older
Enrollment: 245 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 9
States / cities: San Diego, California • Denver, Colorado • Sarasota, Florida + 6 more

Conditions: Hiatal Hernia, Paraesophageal Hernia
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 4
States / cities: St Louis, Missouri • Portland, Oregon • Seattle, Washington

Conditions: Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary; Hypertension
Interventions: Fetal Tracheal Occlusion; Device
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Gastroesophageal Reflux Disease, Hiatal Hernia
Interventions: Lap. Fundo. with Mobilization of the Esophageal Junction, Lap. Fundo. without Mobilization of the Esophageal Junction; Procedure
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: Up to 18 Years
Enrollment: 177 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Birmingham, Alabama • Kansas City, Missouri

Conditions: Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia, Meconium Aspiration, Sepsis
Interventions: Not listed
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 1 Day to 30 Days
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary Artery Hypertension
Interventions: BALT GoldbBAL2 Detachable Balloon, Catheter System; Device
Lead sponsor: Rodrigo Ruano; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 2
States / cities: Miami, Florida • Rochester, Minnesota

Conditions: Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome, Early Infantile Epileptic Encephalopathy, FOXG1 Syndrome, KBG Syndrome, Noonan Syndrome, Severe Hemophilia A, Short Bowel Syndrome, Beta-Propeller Protein-Associated Neurodegeneration, Brain Injury of Prematurity With Periventricular Leukomalacia, Chromosome 17p13.3 Microdeletion Syndrome, Chromosome 1q43-1q44 Deletion, Cockayne Syndrome, Congenital Diaphragmatic Hernia, End-Stage Renal Disease With Cloacal Anomaly, Mitochondrial Depletion Disorder, Severe Factor VII Deficiency
Interventions: Family Centered pediatric palliative care for family caregivers of children with rare diseases.; Behavioral
Lead sponsor: Children's National Research Institute; Other
Eligibility: 12 Months to 99 Years
Enrollment: 480 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Paraesophageal Hernia
Interventions: Laparoscopic paraesophageal hernia repair without fundoplication; Procedure
Lead sponsor: The Foundation for Surgical Innovation and Education; Other
Eligibility: 18 Years and older
Enrollment: 260 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2029
U.S. locations: 2
States / cities: Evanston, Illinois • Portland, Oregon

Conditions: Diaphragmatic Hernia
Interventions: Placement of the GOLDBAL2 balloon; Device
Lead sponsor: Vincent Duron; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Congenital Diaphragmatic Hernia, Tracheoesophageal Fistula, Esophageal Atresia
Interventions: Thoracoscopic surgery; Procedure
Lead sponsor: Arlyne Thung; Other
Eligibility: Up to 6 Months
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Interventions: GoldBAL2 Detachable Balloon and BALTACCIBDPE100 Delivery Catheter; Device
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Hernia, Paraesophageal
Interventions: IV lidocaine, Placebo; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Hernia, DIaphragmatic, Congenital
Interventions: FETO therapy; Device
Lead sponsor: Children's Hospitals and Clinics of Minnesota; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Hiatal Hernia
Interventions: OviTex Reinforced Tissue Matrix; Device
Lead sponsor: Tela Bio Inc; Industry
Eligibility: 22 Years and older
Enrollment: 173 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2032
U.S. locations: 5
States / cities: Mobile, Alabama • Denver, Colorado • Lexington, Kentucky + 2 more

Conditions: Hiatal Hernia
Interventions: Parietex™ Composite Hiatal Mesh, North Haven, CT, Biodesign™ Surgisis® Graft, Cook Medical, Bloomington; Device
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 312 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Stony Brook, New York

Search by objective public record fields.

Antireflux Surgery Without Preoperative Esophageal Manometry

Hiatal Hernia and Pulmonary Involvement

Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) for CDH

Safety and Efficacy of FETO in CDH: A Phase III Trial

Randomized EsophyX Versus Sham / Placebo Controlled TIF Trial: The RESPECT Study

Inflammatory Cytokine Quantification in Infants

Fetal Tracheal Balloon Study in Diaphragmatic Hernia

Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord

Platelet Rich Plasma in Hiatal Hernia Repair

GORE® ENFORM Biomaterial Product Study

Study of Paraesophageal Hernia Repair With Small Intestine Submucosa

Feto-Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia

Necessity of Esophageal Dissection During Laparoscopic Fundoplication

Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO

Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO)

Palliative Care Needs of Children With Rare Diseases and Their Families

Fundoplication in Laparoscopic PEH Repair Based on FLIP

Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)

Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic Surgery

Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia

Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo

Fetoscopic Endoluminal Tracheal Occlusion

Evaluating Clinical Hiatal Hernia Outcomes Using OviTex®

Biologic Versus Synthetic Mesh for Treatment of Paraesophageal Hernia