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ClinicalTrials.gov public records Last synced Oct 2, 2026, 11:43 AM EDT

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Showing 49–72 of 89 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Hernia, Diaphragmatic Clear all
Not yet recruiting Not applicable Interventional

Image-Guided Herniorrhaphy Study

NCT07267494
View directory record Official record
Conditions
Hernia, Hernia Abdominal Wall, Ventral Hernia, Inguinal Hernia, Hiatal Hernia, Diastasis Recti
Interventions
Image-Guided Herniorrhaphy
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo

NCT04096170
View directory record Official record
Conditions
Hernia, Paraesophageal
Interventions
IV lidocaine, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Palliative Care Needs of Children With Rare Diseases and Their Families

NCT06938542
View directory record Official record
Conditions
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome, Early Infantile Epileptic Encephalopathy, FOXG1 Syndrome, KBG Syndrome, Noonan Syndrome, Severe Hemophilia A, Short Bowel Syndrome, Beta-Propeller Protein-Associated Neurodegeneration, Brain Injury of Prematurity With Periventricular Leukomalacia, Chromosome 17p13.3 Microdeletion Syndrome, Chromosome 1q43-1q44 Deletion, Cockayne Syndrome, Congenital Diaphragmatic Hernia, End-Stage Renal Disease With Cloacal Anomaly, Mitochondrial Depletion Disorder, Severe Factor VII Deficiency
Interventions
Family Centered pediatric palliative care for family caregivers of children with rare diseases.
Behavioral
Lead sponsor
Children's National Research Institute
Other
Eligibility
12 Months to 99 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

Safety and Efficacy of FETO in CDH: A Phase III Trial

NCT06884423
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Interventions
FETO with GoldBAL2 Balloon and BALTACCIBDPE100 Catheter
Device
Lead sponsor
Holly L Hedrick, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

Ovitex in Paraesophageal and Large Hiatal Hernia Repair

NCT06193551
View directory record Official record
Conditions
Paraesophageal Hernia, Large Hiatal Hernia
Interventions
Ovitex LPR
Device
Lead sponsor
Foregut Research Foundation
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Lone Tree, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting No phase listed Observational

Esophageal Cancer Risk Registry

NCT00260585
View directory record Official record
Conditions
Esophageal Cancer, Gastroesophageal Reflux Disease (GERD), Esophageal Diseases, Hiatal Hernia, Esophageal Achalasia
Interventions
Survey of client health, personal habits, family history, Blood specimen for non-DNA and DNA parts, Biopsy of esophageal/stomach tissue, lymph nodes, tumor, Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
7,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2050
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Completed Not applicable Interventional

Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord

NCT03242044
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia
Interventions
Congenital diaphragmatic hernia resuscitation with an intact umbilical cord
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 5 Minutes
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 2, 2026, 11:43 AM EDT
Completed Not applicable Interventional

Necessity of Esophageal Dissection During Laparoscopic Fundoplication

NCT00287612
View directory record Official record
Conditions
Gastroesophageal Reflux Disease, Hiatal Hernia
Interventions
Lap. Fundo. with Mobilization of the Esophageal Junction, Lap. Fundo. without Mobilization of the Esophageal Junction
Procedure
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
Up to 18 Years
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Birmingham, Alabama • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 22, 2009 · Synced Oct 2, 2026, 11:43 AM EDT
Completed No phase listed Observational

Maternal-fetal Immune Responses to Fetal Surgery

NCT04484441
View directory record Official record
Conditions
Spina Bifida, Congenital Diaphragmatic Hernia, Lower Urinary Tract Obstructive Syndrome, Myelomeningocele
Interventions
Blood and placenta specimen collection.
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
3
States / cities
Rochester, Minnesota • Cincinnati, Ohio • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair

NCT06444347
View directory record Official record
Conditions
Hiatal Hernia
Interventions
Biosynthetic Mesh, Hiatal Hernia Repair
Device · Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
6
States / cities
Los Angeles, California • New Orleans, Louisiana • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

NCT05962346
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia
Interventions
BALT GOLDBALL 2 detachable latex ballon, BALTACCIBDPE100 Microcatheter, Storz fetoscopic operating sheath and miniature telescope/fetoscope
Device
Lead sponsor
Mauro H. Schenone
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2043
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Active, not recruiting Not applicable Interventional

Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia

NCT02596802
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia
Interventions
FETO therapy
Device
Lead sponsor
Anthony Johnson
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 2, 2026, 11:43 AM EDT
Not yet recruiting Not applicable Interventional

Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Fetuses With Severe CDH

NCT07767825
View directory record Official record
Conditions
Severe Congenital Diaphragmatic Hernia
Interventions
Goldballoon Detachable Balloon (GOLDBAL2)
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting No phase listed Observational

Effect of Hernia Sac Excision on Crural Tension in Paraesophageal Hernia Repair

NCT07197619
View directory record Official record
Conditions
Paraesophageal Hernia
Interventions
Not listed
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 2, 2026, 11:43 AM EDT
Active, not recruiting Not applicable Interventional

Esophagogastric Junction Distensibility During Hiatal Hernia Repair

NCT04450628
View directory record Official record
Conditions
Esophagogastric Junction Distensibility, Hiatal Hernia
Interventions
EndoFLIP
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Completed No phase listed Observational

Early Childhood Follow-up of Congenital Diaphragmatic Hernia Survivors

NCT01029665
View directory record Official record
Conditions
Hernia, Diaphragmatic
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
4 Years to 6 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 12, 2024 · Synced Oct 2, 2026, 11:43 AM EDT
Not yet recruiting Phase 3 Interventional

Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia

NCT06946576
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia
Interventions
Fetoscopic Endoluminal Tracheal Occlusion (FETO) Procedure
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Oct 2, 2026, 11:43 AM EDT
Completed No phase listed Observational

Genetic Analysis of Fraser Syndrome and Fryns Syndrome

NCT00032877
View directory record Official record
Conditions
Fraser Syndrome, Fryns Syndrome, Chromosomal Abnormalities, Abnormalities, Multiple
Interventions
Not listed
Lead sponsor
National Human Genome Research Institute (NHGRI)
NIH
Eligibility
Not listed
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 2, 2026, 11:43 AM EDT
Completed No phase listed Observational

Hiatal Hernia and Pulmonary Involvement

NCT05716022
View directory record Official record
Conditions
Hiatal Hernia, Interstitial Lung Disease
Interventions
Blood Collection, Bronchoscopy
Diagnostic Test
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Completed Phase 2 Interventional Results available

Milrinone in Congenital Diaphragmatic Hernia

NCT02951130
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure, Pulmonary Hypoplasia
Interventions
Milrinone, Placebo (5% Dextrose)
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
0 Hours to 168 Hours
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
19
States / cities
Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 6, 2025 · Synced Oct 2, 2026, 11:43 AM EDT
Enrolling by invitation No phase listed Observational

North American Fetal Therapy Network Prospective Registry for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia

NCT07564297
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia
Interventions
Fetoscopic Endoluminal Tracheal Occlusion, Standard of Care
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2038
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO)

NCT03138863
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary Artery Hypertension
Interventions
BALT GoldbBAL2 Detachable Balloon, Catheter System
Device
Lead sponsor
Rodrigo Ruano
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
2
States / cities
Miami, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) for CDH

NCT02530073
View directory record Official record
Conditions
Congenital Diaphragmatic Hernias
Interventions
Fetoscopic Endoluminal Tracheal Occlusion (FETO)
Device
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2030
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 2, 2026, 11:43 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Biologic Versus Synthetic Mesh for Treatment of Paraesophageal Hernia

NCT02242526
View directory record Official record
Conditions
Hiatal Hernia
Interventions
Parietex™ Composite Hiatal Mesh, North Haven, CT, Biodesign™ Surgisis® Graft, Cook Medical, Bloomington
Device
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 80 Years
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Oct 2, 2026, 11:43 AM EDT