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ClinicalTrials.gov public records Last synced Oct 22, 2026, 9:41 AM EDT

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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: High-flow Nasal Cannula Clear all
Not listed Not applicable Interventional

ROX Index for the Timing of Intubation in Nasal High Flow

NCT04707729
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure
Interventions
ROX index algorithm
Diagnostic Test
Lead sponsor
Hospital Universitari Vall d'Hebron Research Institute
Other
Eligibility
18 Years to 120 Years
Enrollment
630 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Oct 22, 2026, 9:41 AM EDT
Recruiting Not applicable Interventional

Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure

NCT05675345
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure
Interventions
HFNC only, HFNC + CNEP10, HFNC + CNEP20, HFNC + CNEP30
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

High Flow Therapy for the Treatment of Respiratory Failure in the ED

NCT02236559
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Noninvasive positive pressure ventilation (NIPPV), Vapotherm
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
5
States / cities
Athens, Georgia • Florence, South Carolina • Chattanooga, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Extended CPAP on Bronchopulmonary Dysplasia

NCT05547139
View directory record Official record
Conditions
Bronchopulmonary Dysplasia, Prematurity
Interventions
Protocolized weaning of respiratory support
Other
Lead sponsor
Christiana Care Health Services
Other
Eligibility
22 Weeks to 30 Weeks
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Oct 22, 2026, 9:41 AM EDT
Recruiting Not applicable Interventional

HFNC vs NIPPV Following Extubation

NCT05869825
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
High Flow Nasal Canula following extubation, Non-Invasive Positive Pressure Ventilation following extubation
Procedure
Lead sponsor
Emory University
Other
Eligibility
Up to 1 Year
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional

Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection

NCT04694638
View directory record Official record
Conditions
Prone Positioning, Covid19, Hypoxemic Respiratory Failure, ARDS, Non Invasive Ventilation, High Flow Nasal Cannulla
Interventions
Body position change
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 110 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Oct 22, 2026, 9:41 AM EDT
Completed No phase listed Observational

Investigate the Aerosol Particle Distribution During Aerosol Generating Procedures

NCT04353531
View directory record Official record
Conditions
Transmission, Patient Professional, High-flow Nasal Cannula
Interventions
High-flow nasal cannula, Surgical mask, bronchoscopy examination, intubation, tracheostomy, nebulization, Pulmonary function test
Device · Procedure · Diagnostic Test
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 23, 2021 · Synced Oct 22, 2026, 9:41 AM EDT
Terminated Not applicable Interventional Results available

High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation

NCT01270581
View directory record Official record
Conditions
Transient Tachypnea of the Newborn
Interventions
High Flow Nasal Cannula, Bubble Nasal CPAP
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
Up to 24 Hours
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 16, 2017 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional

Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula

NCT04782817
View directory record Official record
Conditions
Intubation, Cardiovascular Surgical Procedure
Interventions
Recommendation for high flow nasal cannula oxygen therapy order set, Provider choice standard care order set
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
3,568 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 22, 2026, 9:41 AM EDT
Not listed Not applicable Interventional

Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation

NCT02460653
View directory record Official record
Conditions
Respiratory Insufficiency, Hypoxia
Interventions
HFNC Flow Rate
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
4 Weeks to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Oct 22, 2026, 9:41 AM EDT
Terminated Not applicable Interventional Results available

Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants

NCT05030012
View directory record Official record
Conditions
Infant, Premature, Neonatal Respiratory Distress, Oxygen Saturation, Bronchopulmonary Dysplasia
Interventions
Automated Control, Manual Control
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Salt Lake City, Utah • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

External Nasal Dilator and Oxygen Therapy in Respiratory Failure

NCT02662387
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
External nasal dilator (END), High flow nasal cannula (HFNC)
Device · Other
Lead sponsor
Loma Linda University
Other
Eligibility
1 Day to 18 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Oct 22, 2026, 9:41 AM EDT
Not listed Not applicable Interventional

HFNC Versus Conventional Nasal Cannula in Oxygen Performance in Patients Receiving Colonoscopy Under IV Sedation

NCT02968706
View directory record Official record
Conditions
Desaturation of Blood
Interventions
High Flow Nasal Cannula, Conventional Nasal Cannula, Patient satisfaction questionnaire
Device · Other
Lead sponsor
Aventura Hospital and Medical Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated Feb 20, 2017 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants

NCT02858154
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
HFNC, Low flow oxygen by nasal cannula
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day to 12 Months
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Kansas City, Kansas • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients

NCT03148262
View directory record Official record
Conditions
Desaturation of Blood, Obesity, Colonoscopy, Sleep Apnea, High Flow Nasal Cannula
Interventions
The Comfort Flo system, The Salter nasal cannula
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional

High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome

NCT02587832
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
HHHFNC, NCPAP
Device
Lead sponsor
Sidra Medicine
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite

NCT02859597
View directory record Official record
Conditions
Morbid Obesity, Noninvasive Ventilation, Deep Sedation
Interventions
High flow nasal cannula, Nasal Cannula
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2020 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional

Evaluation of the Impact of EHR-Alerts on Clinical Decision Support Pathway Use in Bronchiolitis, and the Impact of Pathway Use on the Prescription of High Flow Nasal Cannula and Other Elements of High Value Care.

NCT06932341
View directory record Official record
Conditions
Bronchiolitis
Interventions
Non-interruptive, Interruptive
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 24 Months
Enrollment
2,965 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
St. Petersburg, Florida • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 22, 2026, 9:41 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP

NCT01939067
View directory record Official record
Conditions
Respiratory Distress, Lung Injury
Interventions
Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Hours to 72 Hours
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 15, 2015 · Synced Oct 22, 2026, 9:41 AM EDT
Completed Not applicable Interventional Results available

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Laser Laryngeal Surgery

NCT03086265
View directory record Official record
Conditions
Otorhinolaryngologic Surgical Procedures, Laser Therapy
Interventions
THRIVE, Endotracheal tube
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Oct 22, 2026, 9:41 AM EDT
Terminated Not applicable Interventional

Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT04217746
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Airflow Obstruction
Interventions
High Flow Nasal Cannula
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Oct 22, 2026, 9:41 AM EDT
Completed No phase listed Observational

Premature Infant Exposure to Noise Generated by Respiratory Support

NCT01748214
View directory record Official record
Conditions
Premature Birth of Newborn
Interventions
Not listed
Lead sponsor
University of Virginia
Other
Eligibility
7 Days and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 12, 2012 · Synced Oct 22, 2026, 9:41 AM EDT
Terminated Not applicable Interventional Results available

Comparison Between Gastric and Post Pyloric Tube Feedings in Children With Bronchiolitis Requiring High Flow Nasal Cannula

NCT03346850
View directory record Official record
Conditions
Enteral Feeding in Bronchiolitis
Interventions
Nasogastric tube (NGT) feeding, Nasoduodenal tube (NDT) feeding
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Up to 12 Months
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Oct 22, 2026, 9:41 AM EDT
Active, not recruiting Not applicable Interventional

High Flow Nasal Cannula Compared to Standard Oxygen for Endoscopic Ultrasound

NCT06704867
View directory record Official record
Conditions
Endoscopic Ultrasound
Interventions
High flow nasal cannula
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 22, 2026, 9:41 AM EDT