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ClinicalTrials.gov public records Last synced Oct 24, 2026, 4:55 AM EDT

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Showing 1–24 of 64 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Human Gut Microbiota Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Microbiome Derived Metabolism and Pharmacokinetics

NCT05065671
View directory record Official record
Conditions
Microbial Colonization
Interventions
Tolcapone 100 MG, Duloxetine 20 MG
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Somerville, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

High-Resolution Measurements of Diet-Microbiome Interactions

NCT07856823
View directory record Official record
Conditions
IBS (Irritable Bowel Syndrome)
Interventions
Inulin, Low-fiber control breakfast shake, Atmo Gas-Sensing Capsule, CapScan Regional Fluid-Sampling Capsule
Dietary Supplement · Other · Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors

NCT03032640
View directory record Official record
Conditions
Obesity
Interventions
Oral Glucose Tolerance Test (OGTT), Assessment of dietary compliance, Stool sampling, Sodium Saccharin, Placebo, Lactisole
Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 45 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Oct 24, 2026, 4:55 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants

NCT07043712
View directory record Official record
Conditions
Microbial Colonization, Metabolic Syndrome
Interventions
High pulse consumption
Dietary Supplement
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
20 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Active, not recruiting Not applicable Interventional Results available

Early Protein Supplementation in Extremely Preterm Infants Fed Human Milk

NCT04325308
View directory record Official record
Conditions
Prematurity; Extreme, Feeding Disorder Neonatal, Breast Milk Expression, Growth Failure, Microbial Colonization
Interventions
Protein-enriched human milk diet, Usual human milk diet
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Day to 4 Days
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional

UC Cohort - The Influence of Diet on Gut Microbiotas

NCT04933162
View directory record Official record
Conditions
Ulcerative Colitis
Interventions
High Protein and Low Fiber Diet, Low Protein and High Fiber Diet
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 25, 2023 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Resistant Starch Wheat for Improved Metabolic Health

NCT03082131
View directory record Official record
Conditions
Gut Microbiota, Metabolism, Metabolic Health
Interventions
Resistant Starch Wheat
Dietary Supplement
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
40 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated May 7, 2019 · Synced Oct 24, 2026, 4:55 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human

NCT04267705
View directory record Official record
Conditions
Insulin Sensitivity, Overweight or Obesity, Inflammatory Response
Interventions
Control, Black bean, Chickpea
Other
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Results available

Impacts of Lentils on Metabolism and Inflammation

NCT04283448
View directory record Official record
Conditions
Hypertriglyceridemia, Inflammation, Waist, Hypertriglyceridemic
Interventions
Dietary Lentil, Control
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
18 Years to 70 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 24, 2026, 4:55 AM EDT
Completed No phase listed Observational Results available

Growth and Microbiome Development in Very Low Birth Weight Infants Fed Primarily Mother's Own Milk vs. Donor Human Milk

NCT02573779
View directory record Official record
Conditions
Infant, Very Low Birth Weight
Interventions
Observational - no intervention
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 3 Days
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of a Novel Synbiotic to Change Human Gut Bacteria and Improve Health in Obese Adults

NCT02355210
View directory record Official record
Conditions
Intestinal Microbiota and Barrier Function
Interventions
Bifidobacteria adolescentis BD1, Bifidobacteria animalis subsp. lactis BB-12, Bifidobacteria adolescentis BD1 and galactooligosaccharide, Bifidobacteria animalis subsp. lactis BB-12 and galactooligosaccharide, galactooligosaccharide, Placebo
Dietary Supplement
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Effects of Xylooligosarcharide on Composition of the Human Colonic Microflora

NCT01861964
View directory record Official record
Conditions
Bifidobacteria, Healthy Volunteers
Interventions
Placebo (Maltodextrin), Xylooligosarcharide 1.4g, Xylooligosarcharide 2.8g
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2016 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans

NCT03039023
View directory record Official record
Conditions
Cardiovascular Risk Factor
Interventions
Choline Bitartrate, Pre-cooked, pre-peeled whole hardboiled eggs, Egg whites from pre-cooked, pre-peeled hardboiled eggs, Phosphatidylcholine capsules
Dietary Supplement · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics

NCT02154061
View directory record Official record
Conditions
Influenza
Interventions
IIV Flu Vaccine, Metronidazole, Neomycin, Vancomycin
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 40 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 24, 2026, 4:55 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy

NCT06603519
View directory record Official record
Conditions
Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota, Colorectal Neoplasms, Metabolomics
Interventions
Modified Plant-Based Mediterranean Diet
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Changes in Vaginal, Cervical and Uterine Microflora With Levonorgestrel Intrauterine Device Placement

NCT01496898
View directory record Official record
Conditions
Human Microbiome, Metagenome, Contraception, Cytokine
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Novel Food Product Containing Microbiota Accessible Carbohydrates on the Human Microbiome

NCT03058575
View directory record Official record
Conditions
Gut Microbiome
Interventions
Dietary MACs, Control
Dietary Supplement · Other
Lead sponsor
Access Business Group
Industry
Eligibility
40 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Predicting Adenomatous Polyps in the Colon Using Images of a Human Tongue

NCT06305364
View directory record Official record
Conditions
Colorectal Neoplasms, Gastrointestinal Microbiome
Interventions
Gixam
Device
Lead sponsor
Jubaan Ltd.
Industry
Eligibility
18 Years to 75 Years
Enrollment
426 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
3
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial

NCT02525198
View directory record Official record
Conditions
Mild Cognitive Impairment, Subjective Memory Impairment
Interventions
fatty acid/flavonoid blend, Placebo
Dietary Supplement
Lead sponsor
University of East Anglia
Other
Eligibility
55 Years and older
Enrollment
259 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2024 · Synced Oct 24, 2026, 4:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Kimchi and Gut Health

NCT07435831
View directory record Official record
Conditions
Healthy Adult Participants
Interventions
60 grams per day of intervention food
Other
Lead sponsor
University of California, Davis
Other
Eligibility
19 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
2
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Longitudinal Study of the Human Intestinal Microbiome

NCT00832286
View directory record Official record
Conditions
Dysbacteriosis
Interventions
Ciprofloxacin
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 29, 2021 · Synced Oct 24, 2026, 4:55 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Grape Impact on Human Gut Microbiome

NCT07797803
View directory record Official record
Conditions
Gut Microbiomes
Interventions
Grape Powder, Placebo Powder
Dietary Supplement · Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
45 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adult HMO Supplementation and the Gut Microbiome

NCT06570330
View directory record Official record
Conditions
Healthy Adults
Interventions
SuperHMO, Non-GMO corn Maltodextrin, Rapid Absorption
Dietary Supplement
Lead sponsor
Seeding Inc
Industry
Eligibility
18 Years to 40 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Early Phase 1 Interventional

Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis

NCT06615986
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Cardiosyn
Dietary Supplement
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 99 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 24, 2026, 4:55 AM EDT