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Showing 1–24 of 63 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hypertrophic Scarring Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin

NCT02630303
View directory record Official record
Conditions
Fibrosis, Scarring, Scar, Wounds, Injuries, Keloid, Cicatrix, Hypertrophic
Interventions
LED-RL Phototherapy, Mock Therapy
Device
Lead sponsor
Jared Jagdeo, MD, MS
Federal
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Mather, California
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Phase 2 Interventional

Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery

NCT04877756
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
OLX10010
Drug
Lead sponsor
Olix Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
6
States / cities
Washington D.C., District of Columbia • Miami, Florida • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Jul 23, 2026, 6:17 PM EDT
Not listed Not applicable Interventional

A Substantial Equivalence Study of RD04723 and Predicate Device

NCT01736969
View directory record Official record
Conditions
Hypertrophic Scar, Keloid Scar
Interventions
RD047-023, Predicate Device
Device
Lead sponsor
Oculus Innovative Sciences, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2012 · Synced Jul 23, 2026, 6:17 PM EDT
Active, not recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Randomized Controlled Trial Examining the Efficacy of Botulinum Toxin in Biopsy Scar Minimization

NCT05478551
View directory record Official record
Conditions
Scar, Hypertrophic Scar
Interventions
Botulinum Toxin, Normal saline
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 6:17 PM EDT
Completed No phase listed Observational

Characterization of Dyschromic Hypertrophic Scar

NCT04619589
View directory record Official record
Conditions
Burn Scar, Hypertrophic Scar, Hyperpigmentation, Hypopigmented Scar
Interventions
Not listed
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Jul 23, 2026, 6:17 PM EDT
Recruiting Phase 4 Interventional

Remimazolam vs Propofol in Laser Burn Cases

NCT07213544
View directory record Official record
Conditions
Burn Scar, Hypertrophic Scarring, Procedural Sedation
Interventions
Remimazolam besylate, Propofol
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Functional Usability and Feasibility Testing of the Profound Matrix™ System

NCT06192550
View directory record Official record
Conditions
Wrinkle, Acne Scars - Mixed Atrophic and Hypertrophic
Interventions
Profound Matrix™ System
Device
Lead sponsor
Candela Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
4
States / cities
Marlborough, Massachusetts • New York, New York • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Not applicable Interventional

Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar

NCT03692273
View directory record Official record
Conditions
Burns, Hypertrophic Scar
Interventions
Luminis ultrapulse fractional ablative carbon dioxide laser, 0.5mm punch biopsy
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of EXC 001 in Subjects Who Have Participated in Prior Studies of EXC 001

NCT01494922
View directory record Official record
Conditions
Reduction in Severity of Skin Scarring
Interventions
EXC 001 (currently called PF-06473871)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Lake Worth, Florida • Chicago, Illinois • Eugene, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2021 · Synced Jul 23, 2026, 6:17 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Laser Treatment for the Improvement of Scars and Scleroderma

NCT04567537
View directory record Official record
Conditions
Scars, Scleroderma
Interventions
Laser Treatment
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Jul 23, 2026, 6:17 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Performance of PicoWayTM Picosecond Fractional Laser for Acne Scars

NCT02592993
View directory record Official record
Conditions
Acne Scars - Mixed Atrophic and Hypertrophic
Interventions
PicoWay device
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
18 Years to 75 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
3
States / cities
Chicago, Illinois • New York, New York • Ardmore, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy Study of EXC 001 to Improve the Appearance of Scars From Prior Breast Surgery

NCT01346969
View directory record Official record
Conditions
Reduction in Hypertrophic Skin Scarring
Interventions
EXC 001
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 65 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
12
States / cities
Pasadena, California • Whittier, California • Lake Worth, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Jul 23, 2026, 6:17 PM EDT
Not listed Phase 2 Interventional

Treatment of Hypertrophic Scars With Intradermal Botox

NCT03631368
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
Botox
Drug
Lead sponsor
Roy G. Geronemus, M.D.
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2018 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Phase 2 Interventional

Study to Assess Efficacy and Safety of Dupilumab in the Treatment of Keloids

NCT05128383
View directory record Official record
Conditions
Keloid
Interventions
Dupilumab
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Jul 23, 2026, 6:17 PM EDT
Not listed Not applicable Interventional

Effectiveness of Dry Needling in Linear Scar Tissue

NCT06033430
View directory record Official record
Conditions
Scar Tissue, Hypertrophic Scar, Hypertrophic Scar of Upper Arm (Disorder), Hypertrophic Surgical Scar, Dry Needling
Interventions
True dry needling, Sham dry needling
Other
Lead sponsor
Iran University of Medical Sciences
Other
Eligibility
20 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Jul 23, 2026, 6:17 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Zinc Oxide Versus Petrolatum Following Skin Surgery

NCT03561376
View directory record Official record
Conditions
Surgical Incision, Surgery--Complications, Surgical Wound, Surgical Site Infection, Scar, Hypertrophic Scar
Interventions
Topical zinc oxide vs. petrolatum post-surgical scars
Drug
Lead sponsor
Melissa Pugliano-Mauro
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, PA, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults

NCT02030275
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
RXI-109, Placebo
Drug
Lead sponsor
RXi Pharmaceuticals, Corp.
Industry
Eligibility
21 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
4
States / cities
Lake Worth, Florida • Chicago, Illinois • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2016 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention

NCT03795116
View directory record Official record
Conditions
Fibrosis, Skin Scarring, Skin Wound, Hypertrophic Scar, Scar, Keloid
Interventions
LED-RL phototherapy, Mock irradiation
Device
Lead sponsor
State University of New York - Downstate Medical Center
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Not applicable Interventional Results available

Comparison of 1,550 and 755 Laser in a Split-face Trial

NCT03988049
View directory record Official record
Conditions
Acne Scars - Mixed Atrophic and Hypertrophic
Interventions
1,550 fracionated photothermolysis laser, 755 picosecond laser
Device
Lead sponsor
David Smart
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Jul 23, 2026, 6:17 PM EDT
Terminated Phase 2 Interventional Results available

A Phase 2 Extension Study To Enroll Subjects Who Were Enrolled In B5301001 Study

NCT02205476
View directory record Official record
Conditions
Hypertrophic Scars Resulting From Prior Breast Scar Revision Surgery
Interventions
PF-06473871
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 57 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
5
States / cities
Coral Gables, Florida • Miami, Florida • Atlanta, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Jul 23, 2026, 6:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of Sofwave Treatment for Acne Scars Appearance Improvement

NCT05358860
View directory record Official record
Conditions
Acne Scars - Mixed Atrophic and Hypertrophic
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
22 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
4
States / cities
Hackensack, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Jul 23, 2026, 6:17 PM EDT
Not listed Phase 2 Interventional

Treatment of Hypopigmented Scars With Bimatoprost

NCT06122090
View directory record Official record
Conditions
Scars, Hypopigmented Scar, Hypopigmented Skin, Burn Scar, Scarring, Cicatrix, Hypertrophic, Cicatrix, Pigmentation Disorder, Burns Laser
Interventions
Bimatoprost, Saline
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Jul 23, 2026, 6:17 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Hypertrophic Scar Prevention by Novel Topical Gel Application

NCT03403621
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
Pentamidine Isethionate, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Jul 23, 2026, 6:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming Mastectomy

NCT07147166
View directory record Official record
Conditions
Gender Dysphoria, Mastectomy, Hypertrophic Scar
Interventions
Brijjit® BP100-6 and BP-75, Control: Standard of care and normal wound dressing
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
19 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2032
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 23, 2026, 6:17 PM EDT