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ClinicalTrials.gov public records Last synced Oct 21, 2026, 1:38 PM EDT

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Showing 73–96 of 165 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: IUD Clear all
Withdrawn Phase 2Phase 3 Interventional Accepts healthy volunteers

Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women

NCT04089852
View directory record Official record
Conditions
Contraceptive Devices, Long-Acting Reversible Contraception, Analgesia, Adolescent Health, Gynecology
Interventions
Nitrous oxide gas for inhalation, Oxygen Gas for Inhalation
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
14 Years to 24 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 16, 2022 · Synced Oct 21, 2026, 1:38 PM EDT
Not yet recruiting Phase 2 Interventional

Investigating Pre-Procedural Anxiety and Effect of Analgesia on Intrauterine Device Placement and Endometrial Biopsy

NCT07031206
View directory record Official record
Conditions
Anxiety, Pain
Interventions
Paracervical block- Lidocaine without epinephrine, Benzocaine Gel applied to the cervix, Hydroxyzine Hydrochloride
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of Misoprostol for Intrauterine Device (IUD) Insertion in Nulliparous Women

NCT01001897
View directory record Official record
Conditions
Contraception
Interventions
Misoprostol, Placebo
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 14, 2012 · Synced Oct 21, 2026, 1:38 PM EDT
Recruiting Phase 2 Interventional

Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project

NCT06004674
View directory record Official record
Conditions
Adverse Pregnancy Outcome
Interventions
Lovenox 40mg
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Impact of Contraceptives on Cervico-Vaginal Mucosa

NCT04814927
View directory record Official record
Conditions
Mucosal Inflammation, Contraceptive; Complications, Intrauterine
Interventions
Copper IUD, Etonogestrel implant, Levonorgestrel IUS, DMPA Sub-cutaneous
Drug
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2023 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Study to Assess the Safety of a New Inserter Device for Paragard® (Intrauterine Copper Contraceptive)

NCT05309694
View directory record Official record
Conditions
Contraception
Interventions
Paragard® T380A Intrauterine Copper Contraceptive with New Inserter
Combination Product
Lead sponsor
CooperSurgical Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
8
States / cities
Denver, Colorado • South Miami, Florida • Atlanta, Georgia + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 21, 2026, 1:38 PM EDT
Enrolling by invitation Phase 2 Interventional Accepts healthy volunteers

Oral Ketorolac for IUD Pain Reduction

NCT06853327
View directory record Official record
Conditions
IUD Insertion Pain
Interventions
Ketorolac, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Hillsborough, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 21, 2026, 1:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Patient-centered Information on Permanent Contraception

NCT06296797
View directory record Official record
Conditions
Contraception, Reproductive Behavior, Contraception Behavior
Interventions
Control arm: Existing educational website, Advancing Access Website
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
650 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 21, 2026, 1:38 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Study of Local Anesthesia as a Method to Decrease IUD Insertion Related Pain

NCT01967017
View directory record Official record
Conditions
IUD Insertion Complication, Pain Control
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 21, 2026, 1:38 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Changes in Vaginal, Cervical and Uterine Microflora With Levonorgestrel Intrauterine Device Placement

NCT01496898
View directory record Official record
Conditions
Human Microbiome, Metagenome, Contraception, Cytokine
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Innovative Model of Patient-Centered ConTraception

NCT02364037
View directory record Official record
Conditions
Contraception, Unintended Pregnancy
Interventions
CHOICE Project Structured Contraceptive Counseling, Contraceptive Education Session, Cost Support for IUDs and implants
Behavioral · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
14 Years to 45 Years · Female only
Enrollment
1,008 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
3
States / cities
St Louis, Missouri • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 2, 2020 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Music to Reduce Patient Reported Pain During Intrauterine Device (IUD) Placement in the Office

NCT05068245
View directory record Official record
Conditions
Pain, Acute, Anxiety
Interventions
Preselected classical music
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older · Female only
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 21, 2026, 1:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pilot Study of Suction as a Mechanism of IUD Expulsion With Concomitant Menstrual Cup Use

NCT05254041
View directory record Official record
Conditions
IUD; Complications, Mechanical, Menstrual Cup
Interventions
Menstrual Cup Removal
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

LNG-IUS at 2 Weeks Postpartum

NCT02121067
View directory record Official record
Conditions
Contraception, Malposition of Intrauterine Contraceptive Device
Interventions
Levonorgestrel Intrauterine System (LNG-IUS)
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 24, 2017 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Essential Oils Following IUD Insertion

NCT04927741
View directory record Official record
Conditions
Pain, Muscle, IUD
Interventions
Sweet Marjoram Essential Oil, Grapeseed Oil
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Green Bay, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 31, 2024 · Synced Oct 21, 2026, 1:38 PM EDT
Not yet recruiting Not applicable Interventional

Pain Management for In-Office Gynecologic Procedures Using a Risk-Stratification Pain Calculator

NCT07311824
View directory record Official record
Conditions
Pain Management, Patient Satisfaction, Gynecologic Procedures
Interventions
Pain Calculator
Other
Lead sponsor
Carle Foundation Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Champaign, Illinois • Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Oct 21, 2026, 1:38 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Postplacental Insertion of Levonorgestrel-releasing Intrauterine System (LNG-IUS) After Cesarean vs. Interval Insertion

NCT00635362
View directory record Official record
Conditions
Healthy
Interventions
Levonorgestrel-releasing intrauterine system (LNG-IUS)
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older · Female only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of Immune Cell Changes in the Genital Tract 2 Months After Initiation of an IUD for Contraception

NCT01240811
View directory record Official record
Conditions
Genital Tract Mucosal Immunity, Genital Tract Microflora
Interventions
IUD placement, Levonorgestrel IUD, Copper T380A IUD
Drug
Lead sponsor
Sharon Achilles
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 26, 2017 · Synced Oct 21, 2026, 1:38 PM EDT
Recruiting No phase listed Observational

Feasibility Trial of the Womb Watch Smartphone App To Assess Fetal Movements

NCT07626112
View directory record Official record
Conditions
Assessment of Fetal Movement, Pregnancy, Pregnancy Complications, Pregnancy Complications Affecting Fetus (Diagnosis), Stillbirth, Stillbirth and Neonatal Mortality, Fetal Movement
Interventions
Smartphone Application
Device
Lead sponsor
Kenneth Moise MD
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Austin, Texas • Galveston, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 21, 2026, 1:38 PM EDT
Withdrawn Not applicable Interventional

Transcutaneous Electrical Nerve Stimulation (TENS) for Intrauterine Device (IUD) Insertion Pain

NCT07044622
View directory record Official record
Conditions
Pain
Interventions
Transcutaneous Electrical Nerve Stimulation (TENS)
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Not applicable Interventional Results available

Bleeding Patterns and Complications After Postpartum IUD Placement: a Pilot Study

NCT01309919
View directory record Official record
Conditions
Postpartum Period
Interventions
IUD, Diary
Device · Other
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 29, 2015 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Compare Two Copper IUDs: Mona Lisa NT Cu380 Mini and ParaGard

NCT03124160
View directory record Official record
Conditions
Healthy Women, Female Contraception
Interventions
Mona Lisa® NT Cu380 Mini, ParaGard® TCu380A
Drug
Lead sponsor
FHI 360
Other
Eligibility
16 Years to 40 Years · Female only
Enrollment
1,105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
16
States / cities
Los Angeles, California • Sacramento, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Oct 21, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Allis Clamp Versus Single-tooth Tenaculum

NCT05187078
View directory record Official record
Conditions
IUD
Interventions
Allis clamp, Single-tooth tenaculum
Procedure
Lead sponsor
Brooke Andrews
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 21, 2026, 1:38 PM EDT
Not yet recruiting Phase 2 Interventional

A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer

NCT07349641
View directory record Official record
Conditions
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
Interventions
Medical Device Usage and Evaluation, Tirzepatide
Other · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older · Female only
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Chicago, Illinois • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 21, 2026, 1:38 PM EDT