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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Illicit Substance Use Clear all
Active, not recruiting Not applicable Interventional

Addressing Barriers to Care for Substance Use Disorder Pilot Study

NCT06317987
View directory record Official record
Conditions
Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions
Care Navigation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jul 21, 2026, 11:29 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

First Years Away From Home: Letting Go and Staying Connected

NCT03227809
View directory record Official record
Conditions
Substance Abuse, Risk Reduction, RIsky Sexual Behavior
Interventions
Handbook condition, Handbook plus condition
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
17 Years to 22 Years
Enrollment
910 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Results available

An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care

NCT04907045
View directory record Official record
Conditions
Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions
Health Coaching, Practice Facilitation, Standard Implementation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 21, 2026, 11:29 AM EDT
Active, not recruiting Not applicable Interventional

Supporting Treatment Access and Recovery Through Linkage and Support

NCT05713695
View directory record Official record
Conditions
Mental Health Disorders, Substance Use Disorders
Interventions
Full MISSION, Linkage Only Delivered by a Peer Specialist
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

TAPS-ESP: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use Electronic Spanish Platform

NCT03879785
View directory record Official record
Conditions
Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use
Interventions
Screening
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Early Phase 1 Interventional Results available

Managing Chronic Pain in Veterans With Substance Use Disorders

NCT00982410
View directory record Official record
Conditions
Chronic Pain
Interventions
cognitive-behavioral treatment, educational supportive group
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 12, 2015 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

iSTART: A Campus & Community Initiative for Services in Tec-health

NCT05362357
View directory record Official record
Conditions
Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking, Prescription Opioid Misuse, Illicit Drug Use
Interventions
iSTART Web-app
Behavioral
Lead sponsor
California State University, Northridge
Other
Eligibility
18 Years to 30 Years
Enrollment
1,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Northridge, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stepped Care for Youth Living With HIV

NCT03109431
View directory record Official record
Conditions
HIV, Mental Health, Illicit Substance Use, Sexually Transmitted Infections (STI)
Interventions
Level 1, Level 2, Level 3
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 24 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
2
States / cities
Los Angeles, California • New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 5, 2022 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform

NCT05476588
View directory record Official record
Conditions
Tobacco Use, Alcohol Abuse, Prescription Drug Abuse, Substance Use
Interventions
Screening
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

HOPE Demonstration Field Experiment Multisite Evaluation

NCT01670708
View directory record Official record
Conditions
Substance Use, Criminal Recidivism
Interventions
HOPE, Probation as Usual
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 90 Years
Enrollment
1,504 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
4
States / cities
Benton, Arkansas • Salem, Massachusetts • Oregon City, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 14, 2017 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Results available

Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care

NCT05160233
View directory record Official record
Conditions
Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders, Opioid Use Disorder
Interventions
Standard implementation, Health Coaching, Practice Facilitation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
18,430 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Results available

Data-driven Identification for Substance Misuse

NCT03833804
View directory record Official record
Conditions
Substance Use, Substance Abuse, Substance-Related Disorders
Interventions
Processing of clinical notes in the EHR data collected during routine care
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 89 Years
Enrollment
64,996 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Community Wise: An Innovative Multi-level Intervention to Reduce Alcohol and Illegal Drug Use

NCT02951455
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Critical Dialogue, Capacity Building Project, Quality of Life Wheel, PF, LC
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older · Male only
Enrollment
602 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Not applicable Interventional

AWAITS: A Web-based E-health Application for Active Illicit Opioid Users

NCT03402672
View directory record Official record
Conditions
Opioid-use Disorder, IV Drug Usage, Overdose, Drug Addiction, Substance Use Disorders
Interventions
self-administered, e-health application
Other
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Jul 21, 2026, 11:29 AM EDT
Completed Phase 4 Interventional Results available

Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in HIV-1 Infected Patients With Active Illicit Substance usE

NCT03998176
View directory record Official record
Conditions
HIV-1-infection
Interventions
Bictegravir/emtricitabine/tenofovir alafenamide
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Jul 21, 2026, 11:29 AM EDT
Not listed Not applicable Interventional

Hepatitis C Treatment in Underserved Populations

NCT01717560
View directory record Official record
Conditions
Chronic Hepatitis C, Illicit Drug Use
Interventions
Collaborative, multidisciplinary, integrated care
Other
Lead sponsor
Brian Edlin
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 29, 2012 · Synced Jul 21, 2026, 11:29 AM EDT
Recruiting Phase 2 Interventional

Psilocybin for Opioid Use Disorder (OUD)

NCT06796062
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Psilocybin
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
5
States / cities
Albuquerque, New Mexico • Brooklyn, New York • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 21, 2026, 11:29 AM EDT