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ClinicalTrials.gov public records Last synced Oct 25, 2026, 3:34 AM EDT

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Showing 457–480 of 1,883 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Impaired Cognition Clear all
Completed Not applicable Interventional Results available

Prevention of Early Postoperative Decline

NCT02908464
View directory record Official record
Conditions
Delirium, Postoperative Cognitive Dysfunction
Interventions
Lumosity
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years to 90 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Not applicable Interventional Results available

Computerized Cognitive Training in Breast Cancer Survivors

NCT05570604
View directory record Official record
Conditions
Breast Cancer, Cognitive Change, Cognitive Impairment, Quality of Life
Interventions
Sweep Seeker, Bird Safari, Jewel Diver, Master Gardener, Road Tour, Computerized Crossword Puzzles
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
21 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Phase 1 Interventional Results available

A Study of LY3303560 in Participants With Mild Cognitive Impairment or Alzheimer's Disease

NCT03019536
View directory record Official record
Conditions
Alzheimer Disease
Interventions
LY3303560 - IV, Placebo - IV, Florbetapir F 18, Flortaucipir F18
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
50 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
5
States / cities
Melbourne, Florida • Orlando, Florida • Port Orange, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Oct 25, 2026, 3:34 AM EDT
Not listed Phase 1 Interventional

Nicotine Treatment of Mild Cognitive Impairment (MCI)

NCT00091468
View directory record Official record
Conditions
Age-Related Memory Disorders
Interventions
Transdermal nicotine patch, Placebo transdermal patch
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
55 Years to 90 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Durham, North Carolina • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jan 15, 2008 · Synced Oct 25, 2026, 3:34 AM EDT
Not listed Not applicable Interventional

Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

NCT06179797
View directory record Official record
Conditions
Age-related Cerebral White Matter Changes, Cognition Disorder
Interventions
remote ischemic conditioning
Device
Lead sponsor
Augusta University
Other
Eligibility
56 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 22, 2023 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Not applicable Interventional

COgnitive and Physical Exercise (COPE) Prehabilitation Pilot Feasibility Study

NCT03094988
View directory record Official record
Conditions
Cognitive Impairment, Physical Impairment, Postoperative Complications
Interventions
Cognitive and physical prehabilitation, Active attention control
Behavioral · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Oct 25, 2026, 3:34 AM EDT
Recruiting Not applicable Interventional

Matching Treatments to Cognitive Deficits in Offenders With Substance Use Disorders

NCT06981351
View directory record Official record
Conditions
Antisocial Behavior
Interventions
Attention to Context (ATC) training, Affective Cognitive Control (ACC) training
Behavioral
Lead sponsor
The Mind Research Network
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 25, 2026, 3:34 AM EDT
Not listed Not applicable Interventional

Exercise Targeting Cognitive Impairment in Parkinson's Disease

NCT02267785
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Skill-Based Exercise, Aerobic Exercise, Social Contact
Other
Lead sponsor
University of Southern California
Other
Eligibility
30 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 31, 2019 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Not applicable Interventional

The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status

NCT00469482
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Critically Ill
Interventions
Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.

NCT03368352
View directory record Official record
Conditions
Altitude Hypoxia, Ventilation, Sleep, Oxidative Stress, Neurocognitive Dysfunction
Interventions
Melatonin, Hypoxia
Dietary Supplement · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 31, 2019 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Not applicable Interventional

Intellectual Enrichment to Build Cognitive Reserve in MS

NCT01978574
View directory record Official record
Conditions
Cognitive Impairment in Multiple Sclerosis
Interventions
Intellectual Enrichment daily activities, Intellectual Enrichment documentary videos
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
25 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Oct 25, 2026, 3:34 AM EDT
Terminated Not applicable Interventional Results available

Study of Exelon Transdermal Patch in Amnestic Mild Cognitive Impairment Patients

NCT01602198
View directory record Official record
Conditions
Mild Cognitive Disorder, Mild Cognitive Impairment
Interventions
Exelon [rivastigmine] transdermal patch, Placebo transdermal patch
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
55 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Not applicable Interventional

Think FAST Research Study

NCT04938778
View directory record Official record
Conditions
Age-related Cognitive Decline
Interventions
PNF
Other
Lead sponsor
Arizona State University
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Oct 25, 2026, 3:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Multidisciplinary Intervention for Mild Cognitive Impairment

NCT02943187
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Cognitive training, Nutrition
Behavioral · Dietary Supplement
Lead sponsor
Gibson Institute of Cognitive Research
Industry
Eligibility
50 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Oct 25, 2026, 3:34 AM EDT
Recruiting Not applicable Interventional

VoiceLove Digital Therapy for Delirium in the ICU

NCT07218484
View directory record Official record
Conditions
Delirium
Interventions
VoiceLove therapy
Behavioral
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 25, 2026, 3:34 AM EDT
Active, not recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

NCT05417555
View directory record Official record
Conditions
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
Interventions
Low-Intensity Focused Ultrasound Pulsation (LIFUP)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Phase 4 Interventional Results available

A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.

NCT03811847
View directory record Official record
Conditions
Alzheimer Dementia
Interventions
Methylphenidate Extended Release Oral Capsule, Placebo
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
55 Years to 95 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 2, 2023 · Synced Oct 25, 2026, 3:34 AM EDT
Not yet recruiting Phase 2 Interventional

Flutemetamol F 18 Injection Formulation Comparison

NCT07873463
View directory record Official record
Conditions
Cognitive Dysfunction
Interventions
GE-287, Vizamyl
Drug
Lead sponsor
GE Healthcare
Industry
Eligibility
50 Years to 110 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
6
States / cities
Aventura, Florida • Merritt Island, Florida • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 25, 2026, 3:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

NCT00908999
View directory record Official record
Conditions
Anosognosia, Alzheimer's Disease, Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
60 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 29, 2011 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Not applicable Interventional

Walking on Cognitive Function in Individuals With Mild Cognitive Impairment: A Pilot Project

NCT04498195
View directory record Official record
Conditions
Cognitive Impairment, Mild
Interventions
increased exercise and physical activity
Behavioral
Lead sponsor
Samuel Merritt University
Other
Eligibility
60 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Not applicable Interventional

Effect of Medium Chain Triglyceride Oil Supplementation in Mild Cognitive Impairment

NCT01669200
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Medium Chain Triglyceride Oil, Placebo Oil
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
50 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 29, 2022 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Treatment Resistant Geriatric Depression in Primary Care

NCT01392287
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Memantine
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
55 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 1, 2017 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders

NCT01333098
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Mifepristone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Oct 25, 2026, 3:34 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway

NCT04200911
View directory record Official record
Conditions
Cognitive Impairment, Mild, Alzheimer Disease
Interventions
Rapamune
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
55 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 25, 2026, 3:34 AM EDT