Independent directory Public ClinicalTrials.gov records United States
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Showing 1201–1224 of 1,884 matching trials from the live ClinicalTrials.gov search.
Completed Not applicable Interventional Accepts healthy volunteers

Multicomponent Program for Addressing Cognition in Rural Communities

NCT07018830
Conditions
Cognitive Decline
Interventions
Behavioral Treatment
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
60 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
California State University, San Bernardino
Other
Eligibility
55 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Bernardino, California
Recruiting No phase listed Observational Accepts healthy volunteers

Tennessee Alzheimer's Project

NCT05372172
Conditions
Aging, Alzheimer Disease, Biomarker, Cognitive Dysfunction, Mild Cognitive Impairment, Dementia, Cognition
Interventions
none, observational study
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2030
U.S. locations
1
States / cities
Nashville, Tennessee
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

LpD3.5 Intervention Study in Older Adults- LISA-I Trial

NCT07794956
Conditions
Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis, Leaky Gut Syndrome, Gut Inflammation, Inflammaging
Interventions
LpD3.5, Placebo
Dietary Supplement
Lead sponsor
University of South Florida
Other
Eligibility
60 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Tampa, Florida
Recruiting Not applicable Interventional

taVNS + CCT for Neurocognitive Rehab

NCT07517237
Conditions
Psychosocial Well-being, Neurocognitive Function, Cognitive Complaint, Cognitive Dysfunction
Interventions
taVNS, Computerized Cognitive Training
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
45 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Charleston, South Carolina
Terminated Not applicable Interventional Accepts healthy volunteers Results available

fMRI Guided TMS Enhancement of Associative Memory Networks

NCT02749422
Conditions
Epilepsy
Interventions
MagStim RapidStim2
Diagnostic Test
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 40 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sound and Music for Mild Cognitive Impairment

NCT05064007
Conditions
Mild Cognitive Impairment
Interventions
A: 40 Hz music, B: 40 Hz sound, C: Preferred music
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 95 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Age-Related Memory Disorders
Interventions
ispronicline (nicotinic acetylcholine receptor agonist)
Drug
Lead sponsor
Targacept Inc.
Industry
Eligibility
50 Years to 80 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
15
States / cities
Mesa, Arizona • Peoria, Arizona • Denver, Colorado + 12 more
Conditions
Cognitive Impairment, Hematologic Malignancy
Interventions
Modified ketogenic diet using an exogenous ketogenic formula, Online cognitive training
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
21 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Recruiting Phase 1Phase 2 Interventional

Snacks and Brain Health

NCT07348406
Conditions
Cognitive Assessment, Psychological Function, GI Health
Interventions
Pecan snack, Pretzel snack
Biological
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Lubbock, Texas
Conditions
PARKINSON DISEASE (Disorder)
Interventions
A metacognitive strategy for cognitive rehabilitation called the Multicontext Approach., Cognitive (Process) Training, MC Approach Booster Session
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
50 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Conditions
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Insulin (Humulin® R U-100), Placebo
Drug
Lead sponsor
University of Southern California
Other
Eligibility
55 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
25
States / cities
Phoenix, Arizona • Irvine, California • New Haven, Connecticut + 18 more
Conditions
Schizophrenia
Interventions
SPECT Imaging of Nicotinic Acetylcholine Receptors in Brain
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Terminated Not applicable Interventional Accepts healthy volunteers

Walking Interventions, Cognitive Remediation and Mild Cognitive Impairment

NCT01801943
Conditions
Cognitive Impairment
Interventions
Cognitive Remediation Therapy Group, Walking Intervention (WI) Group, Combination Group, Healthy Living Group
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
65 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Conditions
Sickle Cell Disease, Cognitive Impairment
Interventions
Cogmed
Behavioral
Lead sponsor
Duke University
Other
Eligibility
8 Years to 16 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Enrolling by invitation Not applicable Interventional

Fareon Open Label Device Clinical Trial

NCT07600320
Conditions
Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
Interventions
Fareon device
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
16 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Conditions
Cancer
Interventions
Accelerated repetitive intermittent theta-burst transcranial stimulation (iTBS)
Other
Lead sponsor
Sneha Phadke
Other
Eligibility
18 Years to 99 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Conditions
Prostate Cancer, Sleep Disturbance, Fatigue, Cognitive Impairment
Interventions
teleCBT-I + SH/ReadiWatchTM, SH/ReadiWatchTM
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older · Male only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Completed No phase listed Observational Accepts healthy volunteers Results available

Preoperative Cognitive Screening of Elderly Surgical Patients

NCT01826825
Conditions
Cognitive Impairment
Interventions
Cognitive Screen, Mini-Cog
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Stroke, Stroke Sequelae, Cognitive Impairment
Interventions
Anodal transcranial Direct Current Stimulation (A-tDCS), Sham Intervention
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Phase 1Phase 2 Interventional Results available

Reversal of General Anesthesia With Methylphenidate

NCT02051452
Conditions
Post Operative Cognitive Dysfunction, Emergence From Anesthesia
Interventions
Methylphenidate, Saline
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Memory Disorders, Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Intervention Group, Control Group
Behavioral
Lead sponsor
Boston University
Other
Eligibility
50 Years to 90 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Depression, Mild Cognitive Impairment
Interventions
Donepezil, Placebo, Citalopram, Venlafaxine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
55 Years to 95 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
New York, New York • Durham, North Carolina
Conditions
Delirium, Postoperative, Cognitive Decline, Dementia
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
70 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts