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ClinicalTrials.gov public records Last synced Sep 30, 2026, 11:15 AM EDT

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Showing 49–72 of 691 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Impaired Glucose Tolerance Clear all
Terminated Not applicable Interventional

Exercise Training and Metabolic Flexibility in Prediabetes

NCT04051229
View directory record Official record
Conditions
PreDiabetes, Sedentary Lifestyle
Interventions
6-week exercise training program, Standardized isoenergetic high fat diet
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Sep 30, 2026, 11:15 AM EDT
Recruiting Phase 4 Interventional

Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

NCT05119179
View directory record Official record
Conditions
PreDiabetes
Interventions
Semaglutide
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Brownsville, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Phase 3 Interventional Results available

Effects of Metformin Hydrochloride (HCl) in Combination With Colesevelam HCl, Compared to Metformin HCl Alone, in Patients With Type 2 Diabetes Mellitus and the Effects of Colesevelam HCl on Lipids and Glucose on Pre-diabetic Patients.

NCT00570739
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Hypercholesterolemia, Pre-diabetes
Interventions
Metformin HCl and Colesevelam Placebo, Metformin HCl tablets and Colesevelam tablets, Colesevelam placebo, Colesevelam
Drug
Lead sponsor
Daiichi Sankyo
Industry
Eligibility
18 Years to 79 Years
Enrollment
502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
17
States / cities
Birmingham, Alabama • Los Gatos, California • Tarzana, California + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2010 · Synced Sep 30, 2026, 11:15 AM EDT
Active, not recruiting Not applicable Interventional

Mastering Diabetes Study

NCT04454957
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, PreDiabetes
Interventions
Mastering Diabetes
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 22, 2024 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional

Effects of Almonds on Insulin Sensitivity in Prediabetes

NCT03126981
View directory record Official record
Conditions
PreDiabetes
Interventions
1.5 oz of whole, natural almonds, Low-fat, high refined starches/sugars
Other
Lead sponsor
Midwest Center for Metabolic and Cardiovascular Research
Other
Eligibility
18 Years to 69 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Boca Raton, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Personalized Diet Study to Reduce Glycemic Exposure

NCT03336411
View directory record Official record
Conditions
Pre-diabetes, Overweight and Obesity
Interventions
mHealth, Personalized mHealth
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional Results available

Tolerability, Acceptance, and Utility of Intermittent CGM Use in Youth With Prediabetes

NCT05505565
View directory record Official record
Conditions
PreDiabetes, Obesity, Insulin Resistance
Interventions
Abbott Freestyle Libre 2, Standard physical activity and nutritional counseling for prediabetes management
Device · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
11 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 30, 2026, 11:15 AM EDT
Recruiting Not applicable Interventional

Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

NCT06055036
View directory record Official record
Conditions
Cardiometabolic Syndrome, Physical Inactivity, Hypertension, Type 2 Diabetes, PreDiabetes, Obesity, Cardiovascular Diseases, Smoking, Sleep, Hyperlipidemias, Diet, Healthy, Blood Pressure
Interventions
Black Impact Intervention
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Male only
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Sep 30, 2026, 11:15 AM EDT
Active, not recruiting Not applicable Interventional

Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women

NCT06360536
View directory record Official record
Conditions
Overweight or Obesity, Prediabetes or Diabetes, Prehypertension (Elevated Blood Pressure) or Hypertension, Resistance Training
Interventions
Resistance Training
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
30 Years to 64 Years · Female only
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional

Effects of Sourdough Fermentation Duration and Acid Development on Postprandial Blood Glucose in Prediabetic Adults

NCT06925451
View directory record Official record
Conditions
Insulin Resistance
Interventions
sourdough bread 24, sourdough bread 48, sourdough bread 72, yeast bread
Other
Lead sponsor
Arizona State University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Sep 30, 2026, 11:15 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Almond Effects on Glucose Intolerance Study

NCT02260895
View directory record Official record
Conditions
Prediabetes
Interventions
Almond pre-test snack
Dietary Supplement
Lead sponsor
Memorial Hermann Health System
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Sep 30, 2026, 11:15 AM EDT
Not yet recruiting Not applicable Interventional

Cardiometabolic & Cognitive Effects of Peanut Butter in Prediabetes

NCT07714096
View directory record Official record
Conditions
Prediabetes
Interventions
Peanut butter, Usual diet
Other
Lead sponsor
Penn State University
Other
Eligibility
40 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Cold Induced Changes in White Adipose

NCT02596776
View directory record Official record
Conditions
Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
Interventions
Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
Procedure · Drug · Other
Lead sponsor
Philip Kern
Other
Eligibility
35 Years to 60 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 7, 2020 · Synced Sep 30, 2026, 11:15 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Clinical Utility of SUDOSCAN in the Pediatric Population

NCT02216201
View directory record Official record
Conditions
Childhood Obesity, Prediabetes, Diabetes
Interventions
Not listed
Lead sponsor
Impeto Medical
Industry
Eligibility
8 Years to 17 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2014 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Prediabetes: A Family-Centered Whole Foods Diet in Adults With Prediabetes and Their Offspring

NCT05483972
View directory record Official record
Conditions
PreDiabetes
Interventions
Whole Prediabetes Diet Intervention
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
25 Years to 59 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional Results available

Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

NCT05337098
View directory record Official record
Conditions
Continuous Glucose Monitoring, Oral Glucose Tolerance, Insulin Sensitivity, Inflammatory Markers
Interventions
Non-Nutritive Sweetener Intake and impact on glucose homeostasis
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diabetes Risk Education and Communication Trial

NCT03283657
View directory record Official record
Conditions
PreDiabetes, Diabetes Mellitus, Diabetes Mellitus, Type 2, Body Weight, Body Weight Changes
Interventions
DiRECT, Usual care (UC)
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat

NCT02482610
View directory record Official record
Conditions
Prediabetes
Interventions
Glucose, Glucose with Whole Fat Milk, Glucose with Non-fat Milk
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 50 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 29, 2019 · Synced Sep 30, 2026, 11:15 AM EDT
Terminated No phase listed Observational

Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients

NCT00504218
View directory record Official record
Conditions
Hypopituitarism, Hypogonadism, Thyroid Dysfunction, Bone Diseases, Metabolic
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 24 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Sep 30, 2026, 11:15 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Inflammation Inhibition in Prediabetic Humans

NCT01977417
View directory record Official record
Conditions
Prediabetes, Obese
Interventions
Salsalate, Placebo
Drug
Lead sponsor
Gary L. Pierce
Other
Eligibility
18 Years to 79 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2021
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 11, 2023 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Insulin Sensitivity Using Aerobic Interval Conditioning

NCT01286922
View directory record Official record
Conditions
Pre-diabetes
Interventions
Behavioral: exercise
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
30 Years to 60 Years · Male only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Sep 30, 2026, 11:15 AM EDT
Terminated Phase 2 Interventional Results available

Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity

NCT01351753
View directory record Official record
Conditions
Obesity, Metabolic Syndrome X
Interventions
Metformin, Orlistat, Topiramate, Placebo
Drug
Lead sponsor
University of Iowa
Other
Eligibility
40 Years to 75 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 30, 2026, 11:15 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Exenatide Once Weekly for Smoking Cessation

NCT02975297
View directory record Official record
Conditions
Smoking Cessation
Interventions
Exenatide, NRT, Counseling, Placebo
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Sep 30, 2026, 11:15 AM EDT