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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Infertility,Male Clear all
Active, not recruiting No phase listed Observational

Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration

NCT03291522
View directory record Official record
Conditions
Azoospermia, Nonobstructive, Infertility, Male
Interventions
Ultrasound-guided rete testis flushing and aspiration
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Jul 24, 2026, 1:08 AM EDT
Enrolling by invitation Phase 2 Interventional

Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm

NCT07481370
View directory record Official record
Conditions
Oligospermia, Azoospermia, Nonobstructive, Infertility
Interventions
isotretinoin, Human chorionic gonadotrophin (hCG)
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 50 Years · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Jul 24, 2026, 1:08 AM EDT
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Spermatogonial Differentiation Via Testicular Organoid

NCT06841861
View directory record Official record
Conditions
Infertility, Male, Gene Abnormality, Sterility, Male
Interventions
Stem cell, Genetic Screening, Genetic Reprogramming, Cell Maturation
Genetic
Lead sponsor
CellARTs Inc.
Industry
Eligibility
18 Years to 60 Years · Male only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Jul 24, 2026, 1:08 AM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Validation of New Devices Against Ambient Electromagnetic Radiation

NCT04541459
View directory record Official record
Conditions
Male Infertility
Interventions
new device against ambient electromagnetic radiation, sham device against ambient electromagnetic radiation
Device
Lead sponsor
Waveguard GmbH
Industry
Eligibility
18 Years to 50 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Jul 24, 2026, 1:08 AM EDT
Recruiting Not applicable Interventional

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

NCT04452305
View directory record Official record
Conditions
Infertility, Male, Cancer, Autoimmune Disorder
Interventions
Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jul 24, 2026, 1:08 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Androxal in Male Infertility

NCT02160704
View directory record Official record
Conditions
Infertility
Interventions
Enclomiphene citrate, Placebo
Drug · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 35 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Jul 24, 2026, 1:08 AM EDT
Completed No phase listed Observational

Regulation of Stem Spermatogonia in the Mature Testis

NCT02756923
View directory record Official record
Conditions
Male Infertility
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 75 Years · Male only
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Jul 24, 2026, 1:08 AM EDT
Completed Not applicable Interventional

Attention to Variability During Infertility

NCT03712982
View directory record Official record
Conditions
Infertility, Infertility, Female, Infertility, Male
Interventions
Attention to Variability - Patient Only, Attention to Variability - Partner Only, Attention to Variability - Patient & Partner, Infertility Stories - Reading
Behavioral · Other
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Jul 24, 2026, 1:08 AM EDT
Completed No phase listed Observational

Short Term Genetic Effects of Chemotherapy on Male Germ Cells

NCT02975245
View directory record Official record
Conditions
Cancer
Interventions
Semen collection and analysis
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Jul 24, 2026, 1:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Vitamin E and Male Infertility

NCT00178516
View directory record Official record
Conditions
Male Infertility
Interventions
behavior, procedure
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2009 · Synced Jul 24, 2026, 1:08 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Escitalopram on Sperm DNA Fragmentation

NCT03527043
View directory record Official record
Conditions
Sperm DNA Fragmentation, Infertility, Male
Interventions
Escitalopram, Placebo
Drug · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 24, 2026, 1:08 AM EDT
Completed Not applicable Interventional Results available

Fertility Preservation in Male AYA With Cancer

NCT04268004
View directory record Official record
Conditions
Infertility, Male
Interventions
FP Decision Tool and Discussion
Behavioral
Lead sponsor
Leena Nahata
Other
Eligibility
12 Years to 25 Years · Male only
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Jul 24, 2026, 1:08 AM EDT
Enrolling by invitation No phase listed Observational

Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing

NCT06419127
View directory record Official record
Conditions
Infertility, Female, Infertility, Male, Infertility, IVF, Aneuploidy
Interventions
Timelapse incubation and PGT
Diagnostic Test
Lead sponsor
Gattaca Genomics
Industry
Eligibility
18 Years to 50 Years
Enrollment
2,000 participants
Timeline
2025 – 2033
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jul 24, 2026, 1:08 AM EDT
Completed Phase 2 Interventional Results available

RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia

NCT03323801
View directory record Official record
Conditions
Male Infertility, Azoospermia
Interventions
13-cis retinoic acid
Drug
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 60 Years · Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Jul 24, 2026, 1:08 AM EDT
Completed Phase 2 Interventional Results available

RA-2 13-cis Retinoic Acid (Isotretinoin)

NCT02061384
View directory record Official record
Conditions
Male Infertility, Klinefelter's Syndrome, Y-chromosome Microdeletions
Interventions
13-cis retinoic acid, Calcitriol
Drug
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 60 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Jul 24, 2026, 1:08 AM EDT
Completed Phase 2 Interventional

Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer

NCT00080808
View directory record Official record
Conditions
Prostate Cancer
Interventions
Alprostadil (E1), Papaverine, Phentolamine mesylate, Sildenafil citrate, conventional surgery
Drug · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Up to 65 Years · Male only
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2012 · Synced Jul 24, 2026, 1:08 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Ramipril for the Treatment of Oligospermia

NCT01856361
View directory record Official record
Conditions
Oligospermia, Teratospermia, Asthenozoospermia, Male Infertility
Interventions
Ramipril, Placebo
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Jul 24, 2026, 1:08 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Benefits of Walnuts for Male Reproductive Health

NCT01505140
View directory record Official record
Conditions
Infertility, Nutrition Disorders
Interventions
Whole walnuts
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 35 Years · Male only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2016 · Synced Jul 24, 2026, 1:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

HOP-2A - Intratesticular Hormone Levels

NCT00756561
View directory record Official record
Conditions
Healthy, Male Infertility, Prostate Disease
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 12, 2016 · Synced Jul 24, 2026, 1:08 AM EDT
Completed No phase listed Observational

Understanding Adaptive Challenges Associated With Male-factor Infertility

NCT02607098
View directory record Official record
Conditions
Male-factor Infertility
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Jul 24, 2026, 1:08 AM EDT
Not yet recruiting Not applicable Interventional

Sperm, Exposure and Endocrine Disruptors

NCT07703046
View directory record Official record
Conditions
Fertility, Male Fertility, Sperm Count, Low, Sperm Quality
Interventions
EDC Education Intervention
Behavioral
Lead sponsor
Million Marker Wellness, Inc.
Industry
Eligibility
18 Years and older · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 24, 2026, 1:08 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI)

NCT06990906
View directory record Official record
Conditions
Male Infertility, Azoospermia
Interventions
BAIBYS Sperm selection, Intra cytoplasmatic sperm injection, Conventional manual sperm selection
Device · Procedure
Lead sponsor
BAIBYS Fertility
Industry
Eligibility
21 Years to 42 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 24, 2026, 1:08 AM EDT
Not listed Not applicable Interventional

Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation

NCT04142112
View directory record Official record
Conditions
Infertility, Infertility, Male
Interventions
Ohana IVF Sperm Preparation Kit (OHB035), Standard IVF Preparation Kit (OHB037)
Device
Lead sponsor
Ohana BioSciences
Industry
Eligibility
25 Years to 37 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
7
States / cities
Tempe, Arizona • Clearwater, Florida • Rockville, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2020 · Synced Jul 24, 2026, 1:08 AM EDT
Not listed No phase listed Observational

Relationship of the Microenvironment and Male Fertility

NCT04704141
View directory record Official record
Conditions
Male Infertility, Male Hypogonadism
Interventions
Hormone replacement therapy
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older · Male only
Enrollment
150 participants
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Jul 24, 2026, 1:08 AM EDT