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ClinicalTrials.gov public records Last synced Sep 24, 2026, 4:05 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Injuries, Acute Brain Clear all
Completed Phase 2Phase 3 Interventional Results available

13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF

NCT02786836
View directory record Official record
Conditions
Acute Liver Failure
Interventions
13C-Methacetin
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
11
States / cities
Birmingham, Alabama • San Francisco, California • New Haven, Connecticut + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2020 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness

NCT04930822
View directory record Official record
Conditions
Stroke, Neurologic Disorder, Traumatic Brain Injury, Acquired Brain Injury
Interventions
Table Top Visual Intervention, Bioness Integrated Therapy System Visual Intervention
Other · Device
Lead sponsor
Gaylord Hospital, Inc
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Wallingford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 24, 2026, 4:05 PM EDT
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager (NIRD-HI)

NCT07338383
View directory record Official record
Conditions
Traumatic Brain Injury, Intracranial Hemorrhages, Combat Casualty Care, Point of Care
Interventions
NIRD-HI scan at the time of enrollment, Secondary NIRD-HI scan when a planned repeat CT is performed
Diagnostic Test
Lead sponsor
The Geneva Foundation
Other
Eligibility
18 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 24, 2026, 4:05 PM EDT
Recruiting Not applicable Interventional

CTSN Embolic Protection Trial

NCT06027788
View directory record Official record
Conditions
Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease
Interventions
CardioGard Embolic Protection Cannula, Standard Aortic Cannula
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
60 Years and older
Enrollment
842 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
24
States / cities
North Little Rock, Arkansas • Los Angeles, California • Atlanta, Georgia + 17 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 24, 2026, 4:05 PM EDT
Recruiting No phase listed Observational

The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

NCT06606119
View directory record Official record
Conditions
Trauma Injury, Trauma, Critical Illness, Microbiome, Chronic Anemia, Acute Blood Loss Anemia
Interventions
Data and tissue collection
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Not applicable Interventional Results available

Adjunct VR Pain Management in Acute Brain Injury

NCT04356963
View directory record Official record
Conditions
Traumatic Brain Injury, Headaches Posttraumatic, Trauma, Pain, Acute
Interventions
Virtual Reality Session (VR Blu), Tablet-based Session (Tablet Blu), Use of Virtual Reality Head Mounted Display without Content (VR Blank)
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 23, 2023 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Not applicable Interventional

Hypothermia to Treat Severe Brain Injury

NCT00040339
View directory record Official record
Conditions
Brain Injuries, Hypothermia
Interventions
hypothermia (body temperature lowered to 33°C or 91.4°F)
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
16 Years to 45 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
4
States / cities
St Louis, Missouri • Cincinnati, Ohio • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2008 · Synced Sep 24, 2026, 4:05 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury

NCT05542238
View directory record Official record
Conditions
Spinal Cord Injuries, Cardiovascular Abnormalities, Cerebrovascular Disease; Sequelae, Cognitive Impairment
Interventions
One bout of moderate-intensity sub-maximal aerobic exercise
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 55 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Phase 2 Interventional Results available

Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke

NCT03004976
View directory record Official record
Conditions
Stroke, Stroke, Acute, Brain Injury, Acute
Interventions
Umbilical Cord Blood, Placebo
Biological · Other
Lead sponsor
Joanne Kurtzberg, MD
Other
Eligibility
18 Years to 90 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
6
States / cities
Aurora, Colorado • Gainesville, Florida • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2022 · Synced Sep 24, 2026, 4:05 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Effects of Exercise on Memory in Healthy and Brain-Injured Individuals

NCT01939769
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Exercise - Low-intensity exercise, Exercise - High-intensity exercise
Other
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 45 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Sep 24, 2026, 4:05 PM EDT
Completed No phase listed Observational

Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx

NCT04490005
View directory record Official record
Conditions
Acute Brain Injury, Pupillary Reflex Impaired
Interventions
pupillometry
Other
Lead sponsor
University of Milano Bicocca
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
4
States / cities
San Francisco, California • Baltimore, Maryland • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 24, 2023 · Synced Sep 24, 2026, 4:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stroke and Cerebrovascular Diseases Registry

NCT03281590
View directory record Official record
Conditions
Stroke, Acute Stroke, Acute Brain Injury, Ischemic Stroke, Hemorrhagic Stroke, Transient Ischemic Attack, Subarachnoid Hemorrhage, Cerebral Ischemia, Cerebral Infarction, Cerebral Stroke, Venous Sinus Thrombosis, Cranial
Interventions
Not listed
Lead sponsor
University of New Mexico
Other
Eligibility
1 Year and older
Enrollment
4,594 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 21, 2022 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Not applicable Interventional

The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries

NCT05761925
View directory record Official record
Conditions
Coma, Emotional Distress
Interventions
COMA-F
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 24, 2026, 4:05 PM EDT
Completed No phase listed Observational

Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology

NCT03148340
View directory record Official record
Conditions
Stroke, Stroke, Acute, Ischemic Stroke, Hemorrhage, Clot (Blood); Brain, Subarachnoid Hemorrhage, Cerebral Infarction, Cerebral Hemorrhage, Cerebral Stroke, Intracerebral Hemorrhage, Intracerebral Injury
Interventions
VIPS Monitoring
Diagnostic Test
Lead sponsor
Cerebrotech Medical Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
287 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
5
States / cities
Jacksonville, Florida • Buffalo, New York • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

In-Field Detection of Intracranial Pressure

NCT04515212
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Optic Nerve Ultrasounds
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 99 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2024 · Synced Sep 24, 2026, 4:05 PM EDT
Terminated Phase 4 Interventional Results available

Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

NCT06081283
View directory record Official record
Conditions
Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia, Hypoxia-Ischemia, Brain, Heart Arrest, Stroke, Intracranial Hemorrhages, Coma, Persistent Vegetative State
Interventions
Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product, Valproate Sodium, Fosphenytoin
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Months to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Sep 24, 2026, 4:05 PM EDT
Recruiting Not applicable Interventional

TSCS for Acute SCI

NCT05305118
View directory record Official record
Conditions
Acute Spinal Cord Injury, Blood Pressure, Hypotension
Interventions
TSCS Mapping, Transcutaneous spinal cord stimulation
Procedure · Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 89 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 24, 2026, 4:05 PM EDT
Not listed Not applicable Interventional

Improving Medication Self-Administration and Health After Brain Injury

NCT03885674
View directory record Official record
Conditions
Stroke, Stroke, Acute, Cognitive Impairment, Brain Injuries, Traumatic, Medication Adherence, Medication Compliance
Interventions
Video Call Reminder Condition, Automated Text Message Reminder Condition
Other
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Sep 24, 2026, 4:05 PM EDT
Recruiting No phase listed Observational

Non-Invasive Monitoring Methods in Patients With Acute Brain Injury

NCT06504238
View directory record Official record
Conditions
Brain Injury, Acute
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
720 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Phase 2 Interventional

RCT: Early Rehabilitation Protocol vs. Usual Care in the Pediatric ICU for Children With Acute Brain Injury

NCT02209935
View directory record Official record
Conditions
Pediatric Acute Neurologic Disease, Traumatic and Non-traumatic
Interventions
Early Rehabilitation Protocol, Usual care
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 17 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
3
States / cities
Chicago, Illinois • Cincinnati, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 5, 2017 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Not applicable Interventional Results available

Acute Intermittent Hypoxia in Traumatic Brain Injury

NCT04890639
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Acute Intermittent Hypoxia
Procedure
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 24, 2026, 4:05 PM EDT
Completed No phase listed Observational

Approaches and Decisions for Acute Pediatric TBI Trial

NCT04077411
View directory record Official record
Conditions
Severe Traumatic Brain Injury
Interventions
Observational
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
Up to 18 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
30
States / cities
Birmingham, Alabama • Phoenix, Arizona • La Jolla, California + 25 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2023 · Synced Sep 24, 2026, 4:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Concussion Active Rehabilitation

NCT04248218
View directory record Official record
Conditions
Pediatric ALL, Concussion, Mild, Concussion, Brain, Concussion, Intermediate
Interventions
Active Rehabilitation Group/Case
Behavioral
Lead sponsor
Children's National Research Institute
Other
Eligibility
8 Years to 18 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 29, 2022 · Synced Sep 24, 2026, 4:05 PM EDT
Completed No phase listed Observational

Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation

NCT00205569
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
First Steps Educational Curriculum
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Sep 24, 2026, 4:05 PM EDT