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ClinicalTrials.gov public records Last synced Oct 22, 2026, 2:37 PM EDT

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Showing 481–504 of 1,564 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Injuries, Craniocerebral Clear all
Completed No phase listed Observational Results available

INTRuST Structured Assessment For Evaluation of TBI (SAFE-TBI)

NCT01554891
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
6
States / cities
Washington D.C., District of Columbia • Augusta, Maine • Manchester, New Hampshire + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Oct 22, 2026, 2:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

NCT02592291
View directory record Official record
Conditions
Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries, Spina Bifida, Traumatic Brain Injury
Interventions
MHealth
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 22, 2026, 2:37 PM EDT
Completed Phase 4 Interventional Results available

Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression

NCT01821690
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Buspirone, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 70 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 22, 2026, 2:37 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury

NCT06083441
View directory record Official record
Conditions
Disorder of Consciousness, Consciousness, Loss of, Trauma, Brain, Traumatic Brain Injury, Acute Brain Injury
Interventions
SeeMe, Coma Recovery Scale-Revised (CRS-R)
Diagnostic Test
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Oct 22, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Incidence of Headache Following an Unintentional Dural Puncture

NCT01977898
View directory record Official record
Conditions
Postdural Puncture Headache, Post-Lumbar Puncture Headache, Cerebrospinal Fluid Leaks
Interventions
Morphine, Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 17, 2021 · Synced Oct 22, 2026, 2:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Development of Quality of Life Tool for TBI

NCT00714428
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
485 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
4
States / cities
Palo Alto, California • Tampa, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 7, 2015 · Synced Oct 22, 2026, 2:37 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Test and Evaluation of Non-Invasive Neuro-Assessment Devices (NINAD: Neurokinetics, Inc, iPAS

NCT03465995
View directory record Official record
Conditions
Traumatic Brain Injury, Post Traumatic Stress Disorder
Interventions
NKI i-PAS Diagnostic Protocol
Device
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 13, 2020 · Synced Oct 22, 2026, 2:37 PM EDT
Withdrawn Not applicable Interventional

Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment

NCT01007006
View directory record Official record
Conditions
Traumatic Brain Injury, Posttraumatic Stress Disorders, Trauma, Combat Disorders, Pain
Interventions
TMRDU
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
3
States / cities
Camp Pendleton, California • Tampa, Florida • Fort Knox, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 26, 2019 · Synced Oct 22, 2026, 2:37 PM EDT
Recruiting Not applicable Interventional

Craniomaxillofacial and Upper Extremity Allotransplantation

NCT04057638
View directory record Official record
Conditions
Face Injuries, Hand Injuries, Craniofacial Injuries, Upper Extremity Injuries, Facial Injuries, Facial Deformity
Interventions
Combined Craniomaxillofacial and Upper Extremity Allotransplantation
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 22, 2026, 2:37 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study to Improve Ambulation in Individuals With TBI Using Virtual Reality -Based Treadmill Training

NCT05130658
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Virtual reality treadmill training, Treadmill Training
Device · Other
Lead sponsor
Kessler Foundation
Other
Eligibility
13 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 19, 2023 · Synced Oct 22, 2026, 2:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing an Implementation Strategy for Post-concussion Communication With Low Health Literacy Parents in the Emergency Department

NCT04112914
View directory record Official record
Conditions
Concussion, Brain
Interventions
Post-concussion education for families
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Oct 22, 2026, 2:37 PM EDT
Not listed Not applicable Interventional

Digital Therapeutic for Depression After Head Injury in Current and Former US Military Personnel

NCT05147506
View directory record Official record
Conditions
Depressive Symptoms, Mild Traumatic Brain Injury
Interventions
CNRM DTx, Psychoeducation Comparison
Device · Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Oct 22, 2026, 2:37 PM EDT
Completed Phase 2 Interventional Results available

Safety and Effectiveness of Banked Cord Blood or Bone Marrow Stem Cells in Children With Cerebral Palsy (CP).

NCT01988584
View directory record Official record
Conditions
Cerebral Palsy
Interventions
umbilical cord blood (hUCB) cells, Saline Infusion (Placebo), bone marrow derived mononuclear cells (BMMNCs)
Biological · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
2 Years to 10 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 21, 2022 · Synced Oct 22, 2026, 2:37 PM EDT
Not yet recruiting Not applicable Interventional

Placing External Ventricular Drains Using Assistive Augmented Reality or Image-Based Localization

NCT07042048
View directory record Official record
Conditions
ICH - Intracerebral Hemorrhage, IVH- Intraventricular Hemorrhage, TBI Traumatic Brain Injury
Interventions
EVD placement - image-guidance assisted, EVD placement - AR assisted
Device
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 22, 2026, 2:37 PM EDT
Completed Not applicable Interventional

Neurofeedback Technology (GZNT) for Persistent Post-Concussive Symptoms in Soldiers

NCT02509689
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Global Z-Score Neurofeedback Training
Behavioral
Lead sponsor
The Defense and Veterans Brain Injury Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
1
States / cities
Fort Carson, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Oct 22, 2026, 2:37 PM EDT
Enrolling by invitation Phase 2 Interventional

rTMS Target Identification for Functional Disability in AUD+mTBI

NCT04043442
View directory record Official record
Conditions
Alcohol Use Disorder, Mild Traumatic Brain Injury
Interventions
Magventure MagProX100 with MagOption stimulator and Magpro Cool Coil B65 A/P
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 22, 2026, 2:37 PM EDT
Terminated Phase 4 Interventional Results available

Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

NCT06081283
View directory record Official record
Conditions
Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia, Hypoxia-Ischemia, Brain, Heart Arrest, Stroke, Intracranial Hemorrhages, Coma, Persistent Vegetative State
Interventions
Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product, Valproate Sodium, Fosphenytoin
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Months to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 22, 2026, 2:37 PM EDT
Recruiting Not applicable Interventional

Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

NCT07351305
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder, Traumatic Brain Injury
Interventions
Non-Trauma Treatment for TBI and PTSD
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 22, 2026, 2:37 PM EDT
Recruiting Early Phase 1 Interventional

REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study

NCT07228286
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
Deep brain stimulation (DBS) electrode implantation
Device
Lead sponsor
Samuel Snider, MD
Other
Eligibility
18 Years to 55 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 22, 2026, 2:37 PM EDT
Completed No phase listed Observational

Evaluation of Outcome Measures for Patients Diagnosed With Traumatic Brain Injury

NCT01020318
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 22, 2026, 2:37 PM EDT
Completed Not applicable Interventional

Telephone Delivery of Cognitively Augmented Behavioral Activation (CABA)

NCT04200976
View directory record Official record
Conditions
Traumatic Brain Injury, Posttraumatic Stress Disorder
Interventions
Tele-CABA, Usual Care
Behavioral
Lead sponsor
Portland VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 22, 2026, 2:37 PM EDT
Completed No phase listed Observational

Geriatric Head Trauma Short Term Outcomes Project

NCT04044924
View directory record Official record
Conditions
Head Injury, Anticoagulant-induced Bleeding, Fall
Interventions
Not listed
Lead sponsor
Florida Atlantic University
Other
Eligibility
65 Years and older
Enrollment
5,387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Delray Beach, Florida • West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Oct 22, 2026, 2:37 PM EDT
Terminated Phase 4 Interventional

Combining Observational and Physiologic Sedation Assessment Tools

NCT00538369
View directory record Official record
Conditions
Brain Injury
Interventions
Ramsay Scale, Bispectral index monitor
Other · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2015 · Synced Oct 22, 2026, 2:37 PM EDT
Not listed Not applicable Interventional

Investigating How Sleep After Training Can Affect the Learning of a Motor Skill in Individuals With Brain Injury

NCT04810442
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Nap
Other
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Oct 22, 2026, 2:37 PM EDT