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ClinicalTrials.gov public records Last synced Oct 23, 2026, 5:27 PM EDT

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Showing 481–504 of 1,565 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Injuries, Craniocerebral Clear all
Completed Not applicable Interventional

Improving New Learning and Memory in Traumatic Brain Injury

NCT01207375
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
memory retraining exercises, placebo control memory exercises
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 59 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 3, 2015 · Synced Oct 23, 2026, 5:27 PM EDT
Completed No phase listed Observational Results available

Advanced Visuohaptic Surgical Planning for Trauma Surgery

NCT01056302
View directory record Official record
Conditions
Maxillofacial Injuries
Interventions
Surgical repair of mandibular fractures
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Helmet Technology and Head Impact Exposure

NCT03883451
View directory record Official record
Conditions
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Interventions
Helmet Model
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
13 Years to 25 Years · Male only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Not applicable Interventional

TBI Care: Collaborative Care for Pain After Traumatic Brain Injury (TBI)

NCT03523923
View directory record Official record
Conditions
Brain Injuries, Traumatic, Chronic Pain, Post-Traumatic Headache
Interventions
Collaborative Care
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Oct 23, 2026, 5:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)

NCT00178659
View directory record Official record
Conditions
Brain Injuries, Traumatic, Traumatic Brain Injury
Interventions
Blood/saliva samples for protein/molecular analysis
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
14 Years to 65 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Phase 2 Interventional Results available

Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)

NCT00974259
View directory record Official record
Conditions
Severe Traumatic Brain Injury
Interventions
Management protocol based on pBrO2 and ICP values., Management protocol based on ICP values only.
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
10
States / cities
Miami, Florida • Durham, North Carolina • Cincinnati, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CISBAR Intervention for Social Communication After ABI

NCT05603117
View directory record Official record
Conditions
Brain Injuries
Interventions
Collaborative Interpersonal Strategy Building with Audio Reflection (CISBAR)
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 80 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Oct 23, 2026, 5:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

NCT02592291
View directory record Official record
Conditions
Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries, Spina Bifida, Traumatic Brain Injury
Interventions
MHealth
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 23, 2026, 5:27 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Imaging Characterization of the Biomechanical Coupling of Brain and Skull

NCT05675423
View directory record Official record
Conditions
Traumatic Brain Injury (Tbi), Traumatic Meningeal Enhancement (Tme)
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
21 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Phase 1 Interventional

Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury

NCT02974959
View directory record Official record
Conditions
Traumatic Brain Injury, Acute Brain Injuries
Interventions
gammaCore active device, gammaCore sham device
Device
Lead sponsor
CentraCare
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Not applicable Interventional

Feasibility of Aerobic Exercise for Recovery From Work-related Concussion

NCT06263179
View directory record Official record
Conditions
Concussion, Brain
Interventions
Target Heartrate Aerobic Exercise
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 40 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Williamsville, New York
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 23, 2026, 5:27 PM EDT
Withdrawn Not applicable Interventional

The Utility of Positive Psychology in Military TBI Rehabilitation

NCT04257435
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Positive Psychological Group Treatment, Traditional Behavioral Health Treatment
Behavioral
Lead sponsor
Fort Belvoir Community Hospital
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Oct 23, 2026, 5:27 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

ReadMap: Reading in Stroke Alexia and Typical Aging

NCT06700005
View directory record Official record
Conditions
Aphasia, Stroke, Alexia
Interventions
Not listed
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Oct 23, 2026, 5:27 PM EDT
Not yet recruiting Not applicable Interventional

Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis

NCT07492602
View directory record Official record
Conditions
Stroke, Traumatic Brain Injury, Multiple Sclerosis
Interventions
Functional Electrical Stimulation, Normal care
Device
Lead sponsor
Casa Colina Hospital and Centers for Healthcare
Other
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 23, 2026, 5:27 PM EDT
Recruiting Not applicable Interventional

Auditory Plasticity Training

NCT06628505
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Speech in Noise Training, Spatial Hearing Training Group, Spatial Hearing Control Group
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 55 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 23, 2026, 5:27 PM EDT
Recruiting Not applicable Interventional

Overground Virtual Reality (VR) Gait Rehabilitation for Traumatic Brain Injury (TBI)

NCT07038889
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
C-Mill VR+ by Motek, Walk-over-Ground
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 23, 2026, 5:27 PM EDT
Terminated Phase 2 Interventional

fMRI-neuronavigated rTMS for the Treatment of Major Depression Associated With TBI

NCT02980484
View directory record Official record
Conditions
Major Depressive Disorder, Traumatic Brain Injury
Interventions
Active, Sham
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 23, 2026, 5:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Eye Movement Recordings in the Diagnosis of Traumatic Brain Injury

NCT00875589
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 23, 2026, 5:27 PM EDT
Not listed Early Phase 1 Interventional

Augmentation of Cognitive Training in Children With TBI With D-Cyloserine

NCT02312635
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
D-Cycloserine, Cogmed Working Memory Training
Drug · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
11 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Not applicable Interventional Results available

The Efficacy of Familiar Voice Stimulation During Coma Recovery

NCT00557076
View directory record Official record
Conditions
Traumatic Brain Injury, Coma, Vegetative State, Minimally Conscious State
Interventions
Familiar Auditory Sensory Training, Sham Auditory Sensory Training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Chicago, Illinois • Hines, Illinois • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 6, 2019 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Phase 4 Interventional

The Use of Low Molecular Weight Heparin in Traumatic Brain Injury

NCT00170378
View directory record Official record
Conditions
Brain Injury, Venous Thrombosis
Interventions
Enoxaparin
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Oct 23, 2026, 5:27 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Purpose in Life Survey

NCT05790278
View directory record Official record
Conditions
Breast Cancer, Traumatic Brain Injury
Interventions
Survey
Other
Lead sponsor
Mary Radomski
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 5, 2024 · Synced Oct 23, 2026, 5:27 PM EDT
Completed Early Phase 1 Interventional Results available

The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome

NCT04732338
View directory record Official record
Conditions
Headache, Post-Concussion Syndrome
Interventions
Osteopathic Manipulative Therapy
Other
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Edison, New Jersey
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 23, 2026, 5:27 PM EDT
Terminated Phase 4 Interventional Results available

A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function

NCT01712477
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Intravenous sedation using propofol, Intravenous sedation with midazolam
Drug
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 23, 2026, 5:27 PM EDT