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ClinicalTrials.gov public records Last synced Oct 22, 2026, 10:02 AM EDT

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Showing 529–552 of 1,564 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Injuries, Craniocerebral Clear all
Completed Not applicable Interventional

Cognitive-Communication Screening and Early Therapy for Adults With Mild TBI

NCT03230656
View directory record Official record
Conditions
Concussion, Mild Traumatic Brain Injury, Cognitive Communication Disorder
Interventions
Early cognitive-communication therapy
Other
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 17, 2021 · Synced Oct 22, 2026, 10:02 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Hypovitaminosis D in Neurocritical Patients

NCT02881957
View directory record Official record
Conditions
Craniocerebral Trauma, Intracranial Aneurysm, Brain Neoplasms, Spinal Cord Injuries, Seizures, Meningitis, Stroke, Intracranial Hemorrhages, Critical Illness, Vitamin d Deficiency
Interventions
Cholecalciferol, Placebo
Drug · Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 22, 2026, 10:02 AM EDT
Completed No phase listed Observational

Epigenetic Effects on Traumatic Brain Injury Recovery

NCT04186429
View directory record Official record
Conditions
Traumatic Brain Injury, Orthopedic Injury
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 18 Years
Enrollment
401 participants
Timeline
2017 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 10:02 AM EDT
Enrolling by invitation Not applicable Interventional

SMART-CPT for PTSD/Concussion Implementation

NCT06995612
View directory record Official record
Conditions
PTSD, Concussion, Mild
Interventions
SMART-CPT, CPT
Behavioral
Lead sponsor
San Diego Veterans Healthcare System
Federal
Eligibility
18 Years to 55 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Oct 22, 2026, 10:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Out-of-hospital Cardiac Arrest (OHCA) Biomarkers

NCT03112486
View directory record Official record
Conditions
Neurological Outcome, Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Brain Anoxia Ischemia, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Cardiac Arrest With Successful Resuscitation, Cardiac Arrest, Out-Of-Hospital, Brain Injuries
Interventions
blood draw
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 8, 2020 · Synced Oct 22, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Telemedicine Brain Injury Coping Skills (BICS-T) Support Group for Brain Injury Survivors and Their Caregivers

NCT04371211
View directory record Official record
Conditions
Traumatic Brain Injury, Coping Skills
Interventions
Telemedicine Brain Injury Coping Skills
Behavioral
Lead sponsor
Rehabilitation Hospital of Indiana
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Oct 22, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Innovative Concussion Prevention Device

NCT02901028
View directory record Official record
Conditions
Concussion
Interventions
Laboratory testing, Blood and Urine Draws
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
18 Years to 25 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Oct 22, 2026, 10:02 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials

NCT06963775
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Delphi-MD device (QuantalX Neuroscience Ltd., Saba Israel)
Device
Lead sponsor
Ramon Diaz-Arrastia
Other
Eligibility
18 Years and older
Enrollment
215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 22, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evidence-based Intervention for Improved Head Impact Safety in Youth Football - Aim 1 and Aim 3

NCT04908930
View directory record Official record
Conditions
Head Injury, Sport Injury
Interventions
On-field activity group - Aim 3
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years to 14 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Oct 22, 2026, 10:02 AM EDT
Completed Not applicable Interventional

Building Emotional Self-Awareness Teletherapy (BEST)

NCT05623046
View directory record Official record
Conditions
Concussion, Mild, Concussion, Brain, Concussion, Severe, Concussion, Intermediate, Concussion; Syndrome, Concussion Injury of Cerebrum, Concussion with Brief Loss of Consciousness, Alexithymia
Interventions
Treatment
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Oct 22, 2026, 10:02 AM EDT
Completed Phase 1 Interventional

Mobile Phone Text Message Program to Understand Symptoms and Improve Outcomes in Minor Head Injury Patients

NCT01668342
View directory record Official record
Conditions
Head Injury, Minor
Interventions
SMS assessments & feedback
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Oct 22, 2026, 10:02 AM EDT
Not listed Not applicable Interventional

Theta Burst Stimulation for Headaches After Traumatic Brain Injury

NCT04906603
View directory record Official record
Conditions
Post-Traumatic Headache, Transcranial Magnetic Stimulation, Brain Injuries, Traumatic, Quality of Life
Interventions
Theta Burst Stimulation
Device
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2021 · Synced Oct 22, 2026, 10:02 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of High-Intensity Gait Training Using a Treadmill on Locomotion Recovery in Traumatic Brain Injury Patients

NCT05622786
View directory record Official record
Conditions
Traumatic Brain Injury, Gait Disorders, Neurologic
Interventions
HIGT - physical rehab, Low intensity physical therapy
Other
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2024 · Synced Oct 22, 2026, 10:02 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Platelet Bioenergetics in TBI

NCT04271059
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
Kevin Hatton
Other
Eligibility
18 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Oct 22, 2026, 10:02 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Remediation of Impaired Self-Regulation in Patients With Mild TBI

NCT02260570
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Tolcapone, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 50 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 22, 2026, 10:02 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Disparity Driven Vergence in Mild Traumatic Brain Injury (mTBI)

NCT03529799
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
I-PAS Goggles
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 22, 2026, 10:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Imaging of Traumatic Brain Injury

NCT01196299
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Oct 22, 2026, 10:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Speech in Noise Using Noninvasive Stimulation

NCT07176936
View directory record Official record
Conditions
Traumatic Brain Injury, Hearing Loss
Interventions
Cymba Conchae stimulation, Earlobe stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
25 Years to 55 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 22, 2026, 10:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study to Assess the Effectiveness of the Nautilus BrainPulse™ as an Aid in the Diagnosis of Concussion

NCT02660164
View directory record Official record
Conditions
Concussion
Interventions
Nautilus BrainPulse Recording
Device
Lead sponsor
Jan Medical, Inc.
Industry
Eligibility
10 Years to 25 Years
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
4
States / cities
Fort Lauderdale, Florida • Munster, Indiana • Baton Rouge, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2022 · Synced Oct 22, 2026, 10:02 AM EDT
Not listed Phase 2 Interventional

Evaluate the Effects of Tolcapone on Cognitive and Behavioral Dysfunction in Patients With BI and NCD

NCT02652598
View directory record Official record
Conditions
Brain Injuries, Traumatic, Neurocognitive Disorders, Brain Injuries
Interventions
Tolcapone
Drug
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 19, 2017 · Synced Oct 22, 2026, 10:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury

NCT05762796
View directory record Official record
Conditions
Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
Interventions
tDCS in Youth with mild traumatic brain injury
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
10 Years to 15 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 22, 2026, 10:02 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans

NCT01260740
View directory record Official record
Conditions
Normal Physiology, fMRI
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 70 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 22, 2026, 10:02 AM EDT
Recruiting Not applicable Interventional

Amygdala Memory Enhancement

NCT05065450
View directory record Official record
Conditions
Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury, Cognitive Impairment, Post Traumatic Stress Disorder
Interventions
Intracranial Stimulation
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Oct 22, 2026, 10:02 AM EDT
Active, not recruiting Not applicable Interventional

Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD

NCT05478759
View directory record Official record
Conditions
Brain Injury, Post Traumatic Stress Disorder
Interventions
Multimodal affect recognition training, Attention Training, Brain Health Workshop, National Geographic Movies
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
25 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 22, 2026, 10:02 AM EDT