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ClinicalTrials.gov public records Last synced Oct 24, 2026, 5:25 AM EDT

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Showing 673–696 of 1,565 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Injuries, Craniocerebral Clear all
Completed Phase 2 Interventional Results available

Prospective Analysis of the Use of N-Acetylcysteine and Vitamins in the Treatment of TBI in Geriatric Patients

NCT04291066
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
N-Acetyl cysteine
Drug
Lead sponsor
HonorHealth Research Institute
Other
Eligibility
60 Years to 100 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 24, 2026, 5:25 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Platelet Bioenergetics in TBI

NCT04271059
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
Kevin Hatton
Other
Eligibility
18 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting Not applicable Interventional

Improving Sleep in Veterans With the Polytrauma Clinical Triad

NCT06477796
View directory record Official record
Conditions
Traumatic Brain Injury, Post-traumatic Stress Disorder, Chronic Pain
Interventions
Morning Bright Light Therapy, Negative Ion Generator
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting No phase listed Observational

Augmented Renal Clearance in Neurocritical Care

NCT07410624
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC), Subarachnoid Hemorrhage, Aneurysmal, Ischemic Stroke, Intracerebral Hemorrhage
Interventions
Not listed
Lead sponsor
University of Alberta
Other
Eligibility
18 Years to 85 Years
Enrollment
512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Lexington, Kentucky • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 24, 2026, 5:25 AM EDT
Withdrawn Phase 2 Interventional

A Pilot Trial of Citicoline in Individuals With Mild Traumatic Brain Injury (mTBI)

NCT01591759
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Citicoline, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2014 · Synced Oct 24, 2026, 5:25 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Warfighter Head Injury Study

NCT00754169
View directory record Official record
Conditions
Head Injury
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 75 Years
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 24, 2026, 5:25 AM EDT
Completed Not applicable Interventional Results available

Smart Phone Application for Postconcussion Symptom Reduction

NCT02501642
View directory record Official record
Conditions
Concussion
Interventions
Concussion Coach, Treatment as usual
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Bay Pines, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 24, 2026, 5:25 AM EDT
Not listed No phase listed Observational

Pupillometry for the Prediction of Neurologic Outcomes in Severe Traumatic Brain Injury

NCT02465242
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Oct 24, 2026, 5:25 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

A Highly Portable Device for Assessment of Mild Traumatic Brain Injury in Deployed and Far-Forward Settings

NCT05527041
View directory record Official record
Conditions
Concussion, Brain, Mild Traumatic Brain Injury
Interventions
EyeBOX Lens (EBLens)
Device
Lead sponsor
Oculogica, Inc.
Industry
Eligibility
17 Years to 35 Years
Enrollment
1,600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 24, 2026, 5:25 AM EDT
Completed Phase 4 Interventional

Myobloc Atrophy Study

NCT02052024
View directory record Official record
Conditions
Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI), Brain Injury, Tumor, Stroke
Interventions
Botox, MYOBLOC
Drug
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Dec 16, 2015 · Synced Oct 24, 2026, 5:25 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Australian UCSF Concussion in Athletes

NCT05769296
View directory record Official record
Conditions
Concussion, Mild
Interventions
Headpulse measurements
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2023 · Synced Oct 24, 2026, 5:25 AM EDT
Completed Phase 1 Interventional

Preventing Brain Injury in Infants With Congenital Heart Disease

NCT01426542
View directory record Official record
Conditions
Cyanotic Congenital Heart Disease
Interventions
Topiramate, No medication, but routine heart surgery
Drug · Other
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 2 Months
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2019 · Synced Oct 24, 2026, 5:25 AM EDT
Completed Not applicable Interventional

Hypothermia to Treat Severe Brain Injury

NCT00040339
View directory record Official record
Conditions
Brain Injuries, Hypothermia
Interventions
hypothermia (body temperature lowered to 33°C or 91.4°F)
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
16 Years to 45 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
4
States / cities
St Louis, Missouri • Cincinnati, Ohio • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2008 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mindfulness for Cognition in Early-stage Alzheimer's Disease

NCT06792877
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, TBI (Traumatic Brain Injury), Aging, Healthy Elderly, Alzheimer&Amp;Amp;#39;s Dementia (AD)
Interventions
Mindfulness Intervention, Waitlist then mindfulness
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
50 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Oct 24, 2026, 5:25 AM EDT
Terminated Not applicable Interventional Results available

TBI MR Study 3 Houston Methodist

NCT02218216
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
MRI Diagnostic
Device
Lead sponsor
GE Healthcare
Industry
Eligibility
15 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 24, 2026, 5:25 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Translational Research Center for TBI and Stress Disorders: Virtual Assessment of Deployment Trauma and Rehabilitation

NCT04723745
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), PTSD
Interventions
V-TRACTS Assessment/Feedback, OPTIONAL Brief Assessment of Thinking, OPTIONAL STEP-Home-Brief, OPTIONAL At-home Exercise Program, OPTIONAL Referral to 12-week STEP-Home, OPTIONAL Clinical Referral
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting Phase 4 Interventional

Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures

NCT07225101
View directory record Official record
Conditions
Wound Closure, Brain Tumor Adult, Spine, Neurovascular, Hemorrhagic Stroke, Intracerebral, Traumatic Brain Injury
Interventions
STRATAFIX PDS and Monocryl suture
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting No phase listed Observational

The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

NCT04855396
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
16 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
10
States / cities
San Diego, California • West Palm Beach, Florida • Iowa City, Iowa + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 24, 2026, 5:25 AM EDT
Completed Not applicable Interventional

Comparison of Two Group Wellness Interventions in TBI Partner Caregivers

NCT04192227
View directory record Official record
Conditions
Traumatic Brain Injury, Partner Caregiver
Interventions
EnHAncing BehavIors through wellness TreatmentS (HABITS)
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Indianapolis, Indiana • East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Oct 24, 2026, 5:25 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Measuring Head Impacts in Sports

NCT00060827
View directory record Official record
Conditions
Brain Injuries, Brain Concussion
Interventions
Head Impact Recording Technology (HIRT)
Device
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 24 Years · Male only
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
State College, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 30, 2014 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting Not applicable Interventional

Animal Assisted Therapy After Pediatric Brain Injury: Mediators and Moderators of Treatment Response.

NCT05250180
View directory record Official record
Conditions
Brain Injuries
Interventions
Animal Assisted Therapy, Control
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
4 Years to 24 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting Early Phase 1 Interventional

REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study

NCT07228286
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
Deep brain stimulation (DBS) electrode implantation
Device
Lead sponsor
Samuel Snider, MD
Other
Eligibility
18 Years to 55 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 24, 2026, 5:25 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury

NCT07356167
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Passive neurosensory reintegration training (PNRT)
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 24, 2026, 5:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Traumatic Brain Injury and the Gut Microbiome

NCT04949607
View directory record Official record
Conditions
Brain Injury, Chronic, Brain Injuries, Traumatic
Interventions
Inulin fructooligosaccharide
Dietary Supplement
Lead sponsor
Centre for Neuro Skills
Industry
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Bakersfield, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Oct 24, 2026, 5:25 AM EDT