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ClinicalTrials.gov public records Last synced Oct 11, 2026, 9:59 AM EDT

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Showing 169–192 of 714 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Insulin Resistance Syndrome Clear all
Completed Not applicable Interventional

Paleo Versus Healthy ADA Diets for Treatment of Polycystic Ovarian Syndrome (PCOS)

NCT02190097
View directory record Official record
Conditions
Polycystic Ovarian Syndrome
Interventions
Paleolithic diet, American Diabetes Association diet
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Myocardial Function & FFA Metabolism in HIV Metabolic Syndrome

NCT00656851
View directory record Official record
Conditions
HIV Infections, Cardiovascular Disease, Insulin Resistance, HIV Lipodystrophy, The Metabolic Syndrome
Interventions
Pioglitazone, Exercise Training
Drug · Behavioral
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
28 Years to 50 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 28, 2013 · Synced Oct 11, 2026, 9:59 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Metabolic Syndrome in an Elderly Population is More Linked to Insulin Resistance Than to Obesity

NCT00873964
View directory record Official record
Conditions
Metabolic Syndrome in the Elderly
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
60 Years to 80 Years
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 30, 2012 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Vitamin D for the Treatment of Women With Polycystic Ovary Syndrome (PCOS)

NCT00907153
View directory record Official record
Conditions
Polycystic Ovary Syndrome
Interventions
Vitamin D, Placebo
Dietary Supplement · Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 19, 2017 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional

Nutrition Outreach and Understanding: Research In Serving Hearts Through Healthy Eating And Tailored Support

NCT06460272
View directory record Official record
Conditions
Hypertension, Type2diabetes, Metabolic Syndrome, Obesity
Interventions
Medically Tailored Meals
Other
Lead sponsor
Amanda Shallcross
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Weight and Metabolic Effects of an Almond Enriched Hypocaloric, Low Fat Diet on Overweight and Obese Persons

NCT00194428
View directory record Official record
Conditions
Obesity, Metabolic Syndrome X, Hyperlipidemia, Hypertension
Interventions
Almond enriched diet, Low fat caloric diet
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 75 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2013 · Synced Oct 11, 2026, 9:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes

NCT07095426
View directory record Official record
Conditions
Metabolic Syndrome, Healthy Participants, Metabolically Healthy Obesity, Metabolically Abnormal Obesity
Interventions
inulin
Dietary Supplement
Lead sponsor
Ball State University
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

GLYCOSA Study:Effect of PAP Treatment on Glycemic Control in Patients With Type 2 Diabetes

NCT00509223
View directory record Official record
Conditions
Diabetes Mellitus Type 2
Interventions
Positive Airway Pressure therapy, Lifestyle counseling
Device · Behavioral
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
11
States / cities
Mission Viejo, California • Temecula, California • Coral Gables, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 30, 2013 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Canola Oil Multi-center Intervention Trial II

NCT03054779
View directory record Official record
Conditions
Cardiovascular Disease, Metabolic Syndrome
Interventions
Canola Oil, High oleic acid canola oil, Western diet oil combination
Other
Lead sponsor
Penn State University
Other
Eligibility
20 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome

NCT00170937
View directory record Official record
Conditions
METABOLIC SYNDROME, HYPERTENSION, PRE-HYPERTENSION
Interventions
valsartan plus hydrochlorothiazide
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years to 75 Years
Enrollment
507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2004
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 18, 2016 · Synced Oct 11, 2026, 9:59 AM EDT
Terminated Phase 3 Interventional

Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant

NCT00228176
View directory record Official record
Conditions
Carotid Artery Plaque, Arteriosclerosis, Obesity, Metabolic Syndrome X
Interventions
Rimonabant, Placebo (for Rimonabant)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
55 Years and older
Enrollment
661 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated May 20, 2016 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Cold Induced Changes in White Adipose

NCT02596776
View directory record Official record
Conditions
Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
Interventions
Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
Procedure · Drug · Other
Lead sponsor
Philip Kern
Other
Eligibility
35 Years to 60 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 7, 2020 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cardiac CT's Role in Asymptomatic Patients With Diabetes and Metabolic Syndrome

NCT01564485
View directory record Official record
Conditions
Diabetes, Metabolic Syndrome
Interventions
Cardiac CT, Usual medical care
Diagnostic Test · Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 90 Years
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2016
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Oct 11, 2026, 9:59 AM EDT
Recruiting Not applicable Interventional

The Mom and Infant Outcomes (MOMI) Study

NCT06277661
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Cardiometabolic Syndrome
Interventions
MOMI PODS, Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
Female only
Enrollment
384 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Phosphorus Additives on the Metabolome in Healthy Adults

NCT03841786
View directory record Official record
Conditions
Metabolic Syndrome, Insulin Sensitivity, Cardiovascular Diseases
Interventions
Phosphorus-supplemented study diet, Control Diet
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 29, 2022 · Synced Oct 11, 2026, 9:59 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparison of Two Different Diets on Health Outcomes

NCT00269646
View directory record Official record
Conditions
Metabolic Syndrome X
Interventions
Low-carbohydrate and high-carbohydrate diets
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 64 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 18, 2009 · Synced Oct 11, 2026, 9:59 AM EDT
Terminated Not applicable Interventional

Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients

NCT02174783
View directory record Official record
Conditions
Liver Transplantation, Metabolic Syndrome X, Obesity
Interventions
Control group, Mediterranean diet, Protein-Sparing Modified Fast (PSMF)
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 14, 2017 · Synced Oct 11, 2026, 9:59 AM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

The Effects of Omega-3 Fatty Acids on Metabolic Syndrome

NCT00350194
View directory record Official record
Conditions
Metabolic Syndrome X
Interventions
Omega-3 fatty acids
Dietary Supplement
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 2, 2012 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome

NCT02633488
View directory record Official record
Conditions
Metabolic Syndrome, Insulin Sensitivity
Interventions
Placebos, metformin
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 60 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome

NCT00759291
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
acipimox, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Oct 11, 2026, 9:59 AM EDT
Terminated No phase listed Interventional Results available

Vestibular Stimulation to Trigger Adipose Loss Clinical Trial

NCT03138369
View directory record Official record
Conditions
Obesity, Obesity, Abdominal, Metabolic Syndrome, Weight Loss
Interventions
Vestibular nerve stimulator, Sham vestibular stimulation
Device
Lead sponsor
Neurovalens Ltd.
Industry
Eligibility
22 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women

NCT01748994
View directory record Official record
Conditions
Obesity, Metabolic Syndrome
Interventions
Pioglitazone, Placebo
Drug
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
2
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 30, 2021 · Synced Oct 11, 2026, 9:59 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Human Observatory Study

NCT07646782
View directory record Official record
Conditions
Aging, Mortality, All-cause Mortality, Life Expectancy, Cardiovascular Diseases, Neoplasms, Cognitive Dysfunction, Metabolic Syndrome, Frailty, Musculoskeletal Disease, Neurodegenerative Disease, Dementia, Activities of Daily Living, Health Related Quality of Life, Environmental Exposure, Occupational Diseases, Health Equity, Social Determinants of Health, Physical Disability
Interventions
Multi-Domain Ecological and Clinical Data Linkage
Other
Lead sponsor
Longevity Metrics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2099
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 11, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Prolonged Standing Compared to Prolonged Sitting on Postprandial Lipemia

NCT03089437
View directory record Official record
Conditions
Metabolic Syndrome, Atherosclerosis
Interventions
Prolonged Standing, Prolonged Sitting
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 40 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 4, 2018 · Synced Oct 11, 2026, 9:59 AM EDT