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Showing 1–24 of 137 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Insulin Response Clear all
Completed Phase 4 Interventional Results available

Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome

NCT00666848
View directory record Official record
Conditions
Metabolic Syndrome, Hypertension
Interventions
Placebo, Enalapril 5mg, Enalapril 10mg, Sitagliptin
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 10, 2012 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Not applicable Interventional

The Dose-response Effects of High Intensity Functional Training on Metabolic Syndrome Risk Factors

NCT05001126
View directory record Official record
Conditions
Metabolic Syndrome, Atherogenic Dyslipidemia, Insulin Resistance, Endothelial Dysfunction
Interventions
HIFT 1x/week, HIFT 2x/week, HIFT 3x/week
Behavioral
Lead sponsor
Gary Van Guilder
Other
Eligibility
35 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Gunnison, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Jul 23, 2026, 4:25 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Dose Response Study of Transdermal Human Insulin in Patients

NCT05159453
View directory record Official record
Conditions
Glucose, High Blood
Interventions
Human Insulin, Finger-actuated, Metered Pump Sprayer
Biological · Device
Lead sponsor
Transdermal Delivery Solutions Corp
Industry
Eligibility
25 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Palm Beach Gardens, Florida
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Not applicable Interventional Results available

The Effects of Obesity and Obstructive Sleep Apnea on Inflammation and Heart Disease

NCT00371293
View directory record Official record
Conditions
Sleep Apnea Syndromes, Inflammation
Interventions
Weight Loss Program, CPAP therapy
Behavioral · Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Jul 23, 2026, 4:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes

NCT07095426
View directory record Official record
Conditions
Metabolic Syndrome, Healthy Participants, Metabolically Healthy Obesity, Metabolically Abnormal Obesity
Interventions
inulin
Dietary Supplement
Lead sponsor
Ball State University
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jul 23, 2026, 4:25 PM EDT
Not listed No phase listed Observational

A Five-Year Quality of Life Study for Cancer Patients

NCT01539148
View directory record Official record
Conditions
Cancer
Interventions
Not listed
Lead sponsor
Constantine A. Kotsanis
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Grapevine, Texas
Source: ClinicalTrials.gov public record
Updated May 2, 2013 · Synced Jul 23, 2026, 4:25 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adolescents

NCT02499705
View directory record Official record
Conditions
Insulin Resistance, Obesity
Interventions
Sucralose, Sucrose, Sucralose + maltodextrin
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
13 Years to 17 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Cottonseed Oil on Oxidative Stress, Inflammation, and Metabolism

NCT05439590
View directory record Official record
Conditions
Inflammation, Healthy, Oxidative Stress, Metabolic Syndrome
Interventions
High dose CSO, Low dose CSO, Low dose OO, High dose OO
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
18 Years to 55 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study of Strawberries and Disease Risk

NCT01199848
View directory record Official record
Conditions
Nutritional and Metabolic Diseases, Inflammation, Physiological Responses
Interventions
Placebo, 10G, 20G, 40G, Placebonofiber
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 11, 2021 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Phase 3 Interventional

A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes

NCT00312130
View directory record Official record
Conditions
Pre-diabetes
Interventions
Vildagliptin
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 17, 2016 · Synced Jul 23, 2026, 4:25 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Pharmacogenetics of Response to GLP1R Agonists

NCT05071898
View directory record Official record
Conditions
Obesity, Diabetes Type 2
Interventions
Semaglutide Pen Injector [Ozempic]
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 89 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Jul 23, 2026, 4:25 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Effect of EGCG on the Body's Response to Insulin

NCT00434499
View directory record Official record
Conditions
Hypertension, Obesity, Type 2 Diabetes, Insulin Resistance
Interventions
EGCG
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Jul 23, 2026, 4:25 PM EDT
Withdrawn Phase 4 Interventional

Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer

NCT04741204
View directory record Official record
Conditions
Breast Cancer Stage, Insulin Resistance, Racial Bias
Interventions
Metformin Extended Release Oral Tablet
Drug
Lead sponsor
Woman's
Other
Eligibility
18 Years to 80 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 5, 2023 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Phase 4 Interventional Results available

Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis

NCT02078882
View directory record Official record
Conditions
Primary Biliary Cirrhosis
Interventions
abatacept
Biological
Lead sponsor
Christopher Bowlus, MD
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2020 · Synced Jul 23, 2026, 4:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Snack Types on Acute Glucose and Insulin Response

NCT03956602
View directory record Official record
Conditions
Satiety
Interventions
Pretzels, Brazil nuts, Potato chips, Mixed nuts, White bread, Dried mango, Mango fruit
Other
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 55 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jul 23, 2026, 4:25 PM EDT
Not listed Not applicable Interventional

Weight Loss and Abdominal Fat Responses to Different Diet Compositions

NCT01034046
View directory record Official record
Conditions
Obesity, Insulin Resistance, Metabolic Syndrome
Interventions
Low Carbohydrate Diet, Low Fat Diet
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 29, 2010 · Synced Jul 23, 2026, 4:25 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance

NCT04708535
View directory record Official record
Conditions
Insulin Resistance, Insulin Sensitivity, Obesity, Inflammation
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
30 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Not applicable Interventional

The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit

NCT00282594
View directory record Official record
Conditions
Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
Interventions
Novolin R (human recombinant Insulin)
Drug
Lead sponsor
Genesys
Other
Eligibility
18 Years and older
Enrollment
317 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Grand Blanc, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 26, 2006 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

To Evaluate the Hormonal Response to Low Blood Sugar After a Single Oral Dose of AZD1656 Suspension

NCT00790153
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Insulin, AZD1656
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
20 Years to 45 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chula Vista, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2009 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Not applicable Interventional Results available

Physiologic Response to Glucagon at Varying Insulin Levels

NCT01483651
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
Glucagon, Insulin
Drug
Lead sponsor
Legacy Health System
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 28, 2016 · Synced Jul 23, 2026, 4:25 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of the Inclusion of Soybean Flour on Glycemic Responses

NCT06280625
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Replacement of wheat flour by soyflour
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 45 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 23, 2026, 4:25 PM EDT
Withdrawn Phase 2 Interventional

Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI

NCT02585765
View directory record Official record
Conditions
Spinal Cord Injury, Pressure Ulcers
Interventions
Pioglitazone, Placebo
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 79 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2018 · Synced Jul 23, 2026, 4:25 PM EDT
Completed Phase 2 Interventional Results available

Phase II Pharmacokinetics Study of Humalog and Humulin-R With and Without rHuPH20 in Type 1 Diabetes Mellitus

NCT00774800
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
Humalog, Humulin-R, Recombinant human hyaluronidase PH20 (rHuPH20), Liquid meal
Drug · Other
Lead sponsor
Halozyme Therapeutics
Industry
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chula Vista, California
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Jul 23, 2026, 4:25 PM EDT
Terminated Not applicable Interventional Results available

Increasing Cure Rate of Hepatitis C Therapy in Obese Hepatitis C Patients

NCT00871845
View directory record Official record
Conditions
Obesity, Insulin Resistance, Metabolic Syndrome, Hepatitis C
Interventions
Dietary and Lifestyle modification educational sessions
Behavioral
Lead sponsor
Hossam Kandil
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 4, 2018 · Synced Jul 23, 2026, 4:25 PM EDT