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ClinicalTrials.gov public records Last synced Oct 7, 2026, 3:34 AM EDT

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Showing 145–168 of 320 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Insulin Sensitivity/Resistance Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Replacing Refined Carbohydrates With Healthy Fats on Cardio-metabolic Markers

NCT02695433
View directory record Official record
Conditions
Pre-diabetes, Metabolic Syndrome
Interventions
Active, Control
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
25 Years to 60 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Oct 7, 2026, 3:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Milk Fat Intake and Metabolic Health Markers

NCT02659748
View directory record Official record
Conditions
Insulin Sensitivity, Type 2 Diabetes
Interventions
Milk Fat, Control Fat
Dietary Supplement
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years to 40 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Oct 7, 2026, 3:34 AM EDT
Completed No phase listed Observational

Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus

NCT01663220
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Not listed
Lead sponsor
Foundation for the National Institutes of Health
Other
Eligibility
30 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2013 · Synced Oct 7, 2026, 3:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Changes in Insulin Sensitivity After Weight Loss

NCT00627484
View directory record Official record
Conditions
Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
Interventions
Gastric bypass, Gastric banding, Sleeve gastrectomy, Very low calorie diet
Procedure · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 75 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2019 · Synced Oct 7, 2026, 3:34 AM EDT
Completed Not applicable Interventional Results available

Metabolic Effects of Switching Kaletra to Boosted Reyataz

NCT00413153
View directory record Official record
Conditions
HIV Infections
Interventions
atazanavir/ritonavir, lopinavir/ritonavir
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2010 · Synced Oct 7, 2026, 3:34 AM EDT
Terminated Not applicable Interventional

The Effect of Time-Restricted Eating in Cardiometabolic Health

NCT04484987
View directory record Official record
Conditions
Obesity, Pre-diabetes
Interventions
9 hours daily eating window, 15 hours daily eating window
Other
Lead sponsor
University of California, Davis
Other
Eligibility
21 Years to 70 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 7, 2026, 3:34 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Pharmacogenetics of Response to GLP1R Agonists

NCT05071898
View directory record Official record
Conditions
Obesity, Diabetes Type 2
Interventions
Semaglutide Pen Injector [Ozempic]
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 89 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 7, 2026, 3:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comprehensive Postpartum Screening Strategies for Women With Gestational Diabetes Mellitus (GDM)

NCT00849849
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Not listed
Lead sponsor
Woman's
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
214 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Oct 7, 2026, 3:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Hi-maize Resistant Starch on Insulin Sensitivity

NCT01058135
View directory record Official record
Conditions
Insulin Resistance
Interventions
Hi-maize starch (Low dose), Hi-maize starch (High-dose), Control (starch)
Other
Lead sponsor
Ingredion Incorporated
Industry
Eligibility
18 Years to 69 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Glen Ellyn, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2016 · Synced Oct 7, 2026, 3:34 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity

NCT07128368
View directory record Official record
Conditions
Resistance Training
Interventions
Resistance Exercise Training
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 12, 2025 · Synced Oct 7, 2026, 3:34 AM EDT
Completed No phase listed Observational

Association Between Vitamin D and Inflammation and Diabetes Risk in Morbidly Obese Pre-Menopausal Women

NCT02169050
View directory record Official record
Conditions
Insulin Sensitivity
Interventions
Not listed
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years to 49 Years · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 7, 2026, 3:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep, Exercise and Insulin Sensitivity

NCT03556410
View directory record Official record
Conditions
Obesity
Interventions
sleep, exercise
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
21 Years to 40 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 7, 2026, 3:34 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)

NCT02366481
View directory record Official record
Conditions
Obesity, Insulin Resistance, Insulin Sensitivity, Beta-Cell Dysfunction, Prediabetes
Interventions
Placebo, Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
Dietary Supplement
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2019 · Synced Oct 7, 2026, 3:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Orange Juice And Sugar Intervention Study

NCT03527277
View directory record Official record
Conditions
Cardiovascular Risk Factor, Type2 Diabetes Mellitus, Insulin Sensitivity, Metabolic Syndrome
Interventions
Naturally-sweetened orange juice, Sugar-sweetened beverage
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 50 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 7, 2026, 3:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Red Raspberries on Insulin Action and Oxidative Stress

NCT02479035
View directory record Official record
Conditions
Insulin Resistant
Interventions
Red raspberry meal 1, Red raspberry meal 2, Control meal
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 5, 2021 · Synced Oct 7, 2026, 3:34 AM EDT
Active, not recruiting No phase listed Observational

MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus

NCT03945747
View directory record Official record
Conditions
Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1, Autoimmune Diabetes, Juvenile Diabetes, Diabetes Mellitus Complication, Diabetic Nephropathies, Metabolic Disease, Diabetic Kidney Disease
Interventions
Blood draw, Urine sample collection, DXA scan
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
7 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 7, 2026, 3:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding Dose Related Effects of Strawberry

NCT06173765
View directory record Official record
Conditions
Pre-diabetes, Insulin Sensitivity, Insulin Resistance, Inflammation
Interventions
freeze-dried whole strawberry powder 36 g powder, freeze-dried whole strawberry powder 12 g, freeze-dried control powder 0 g strawberry
Other
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 60 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 7, 2026, 3:34 AM EDT
Completed No phase listed Observational

Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity

NCT00936130
View directory record Official record
Conditions
Obesity, Protein-energy; Imbalance, Insulin Sensitivity, Gastrointestinal Complication
Interventions
Laparoscopic Roux-en-Y gastric bypass, Laparoscopic gastric banding, Laparoscopic sleeve gastrectomy, Low Calorie Diet
Procedure · Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 4, 2015 · Synced Oct 7, 2026, 3:34 AM EDT
Completed Not applicable Interventional

Trial of Aerobic Exercise Training in Stroke Survivors

NCT00891514
View directory record Official record
Conditions
Stroke, Insulin Resistance, Sedentary Lifestyle
Interventions
Aerobic Exercise, Stretching
Behavioral
Lead sponsor
Baltimore VA Medical Center
Federal
Eligibility
40 Years to 75 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 7, 2026, 3:34 AM EDT
Completed No phase listed Observational Results available

Activity, Adiposity, and Appetite in Adolescents 2

NCT04028921
View directory record Official record
Conditions
Obesity, Metabolic Disease, Insulin Sensitivity
Interventions
No intervention
Other
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
14 Years to 17 Years
Enrollment
46 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 7, 2026, 3:34 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

NCT04055428
View directory record Official record
Conditions
Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease, Natriuretic Peptides, Metabolism, Energy Expenditure
Interventions
Sacubitril, Valsartan 97-103 mg Oral Tablet, Valsartan 160 mg, Intravenous Glucose Tolerance Test, Standardized Meals, Exercise capacity VO2 maximum determination
Drug · Other · Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 7, 2026, 3:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women

NCT04066283
View directory record Official record
Conditions
Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation, Insulin Sensitivity, Blood Pressure, Lipid Disorder, Appetitive Behavior
Interventions
No intervention
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 7, 2026, 3:34 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects

NCT02267317
View directory record Official record
Conditions
Insulin Sensitivity
Interventions
Eritoran, D5W
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 4, 2020 · Synced Oct 7, 2026, 3:34 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Preoperative Oral Carbohydrate Drink for Elective Cesarean Delivery and the Effect on Insulin Sensitivity

NCT03494868
View directory record Official record
Conditions
Insulin Sensitivity
Interventions
Carbohydrate Drink
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Oct 7, 2026, 3:34 AM EDT