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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Intensive Care Neurological Disorder Clear all
Recruiting Not applicable Interventional

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

NCT06411561
View directory record Official record
Conditions
Critical Illness, Delirium, Cognitive Impairment, Cognitive Decline, Alzheimer's Disease, Dementia, Circadian Dysrhythmia, Sleep Disturbance
Interventions
SLEEP + COG, COG, SLEEP, AC
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 22, 2026, 11:57 AM EDT
Completed No phase listed Observational

Effects Of Invasive And Noninvasive Mechanical Ventilation On Sleep In The Intensive Care Unit (ICU)

NCT00638339
View directory record Official record
Conditions
Respiratory Insufficiency, Respiration, Artificial, Sleep Deprivation
Interventions
Not listed
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2019 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Not applicable Interventional Results available

A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU.

NCT00766051
View directory record Official record
Conditions
Cerebral Palsy, Sensorimotor Deficits, Sensory Processing Disorder, Feeding Problems, Developmental Coordination Disorder, Picky Eaters, NICU
Interventions
The intervention group: Neurophysiologically Based Occupational Therapy Intervention (NBOTI)
Other
Lead sponsor
University of Utah
Other
Eligibility
29 Weeks to 44 Weeks
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 1, 2017 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Phase 4 Interventional

Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?

NCT01791296
View directory record Official record
Conditions
Sleep Deprivation, Delirium
Interventions
Dexmedetomidine, Placebo
Drug · Other
Lead sponsor
Maisonneuve-Rosemont Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Jul 22, 2026, 11:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient and Caregiver Psychological Functioning Following Neuro-ICU Admission: A Prospective Investigation

NCT02435641
View directory record Official record
Conditions
Intensive Care Neurological Disorder
Interventions
Questionnaires
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Jul 22, 2026, 11:57 AM EDT
Recruiting Not applicable Interventional

Neurosteer Bedside Monitoring System

NCT06718764
View directory record Official record
Conditions
Delirium, Sedation, Agitation
Interventions
Neurosteer's single-channel EEG monitoring device
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

White Noise to Improve Sleep in the Medical Intensive Care Unit (MICU): a Pilot and Feasibility Study

NCT03755011
View directory record Official record
Conditions
Sleep Deprivation
Interventions
white noise, usual care
Device · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 31, 2019 · Synced Jul 22, 2026, 11:57 AM EDT
Active, not recruiting Not applicable Interventional

Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers

NCT05157880
View directory record Official record
Conditions
Acute Neurological Injury, Emotional Distress
Interventions
Recovering Together
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
388 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Not applicable Interventional Results available

Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness

NCT00709124
View directory record Official record
Conditions
Intensive Care Unit, Muscle Weakness
Interventions
Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA), Sham
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jul 22, 2026, 11:57 AM EDT
Completed No phase listed Observational

Actigraphy to MEasuRe Intensive Care Unit Activity

NCT02263716
View directory record Official record
Conditions
Disability, Physical Activity, Aging, Critical Illness
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 5, 2017 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Not applicable Interventional Results available

Neurosciences-Intensive Care Unit Electrical Stimulation

NCT03547687
View directory record Official record
Conditions
Intensive Care (ICU) Myopathy
Interventions
Electrical Stimulation Treatment, Neuromuscular Electrical Stimulation Treatment
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Phase 2 Interventional Results available

The Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage

NCT01095731
View directory record Official record
Conditions
Aneurysmal Subarachnoid Hemorrhage
Interventions
Tiopronin, Placebo
Drug
Lead sponsor
E. Sander Connolly
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Gainesville, Florida • New York, New York • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Not applicable Interventional Results available

Vanderbilt ICU Recovery Program Pilot Trial

NCT03124342
View directory record Official record
Conditions
Intensive Care Unit Syndrome, Intensive Care Neurological Disorder, Intensive Care (ICU) Myopathy, Intensive Care Psychiatric Disorder (Diagnosis)
Interventions
VANDERBILT ICU RECOVERY PROGRAM
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Jul 22, 2026, 11:57 AM EDT
Not yet recruiting No phase listed Observational

Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients

NCT07577713
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke, Delayed Emergence From Anesthesia, Encephalopathy
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Not applicable Interventional

Reiki Intervention for Seriously Ill Elders Intensive Care Unit (RISE-ICU)

NCT03685760
View directory record Official record
Conditions
Mechanical Ventilation Complication, Complementary Health Approach
Interventions
Reiki therapy, Sham Reiki
Other
Lead sponsor
Ohio State University
Other
Eligibility
55 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Phase 4 Interventional Results available

Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention

NCT00618436
View directory record Official record
Conditions
Traumatic Brain Injury, Subarachnoid Hemorrhage
Interventions
Levetiracetam, Phenytoin
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 6, 2014 · Synced Jul 22, 2026, 11:57 AM EDT
Active, not recruiting No phase listed Observational

The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors

NCT00392795
View directory record Official record
Conditions
Delirium, Cognition Disorders, Dementia
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
826 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2026
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 22, 2026, 11:57 AM EDT
Completed Not applicable Interventional Results available

Building Resiliency in Patients Admitted to the Neuroscience Intensive Care Unit and Their Caregivers

NCT03694678
View directory record Official record
Conditions
Acute Brain Injuries
Interventions
Recovering Together
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Jul 22, 2026, 11:57 AM EDT
Completed No phase listed Observational

Pain Assessment in the Intensive Care Unit

NCT01628185
View directory record Official record
Conditions
Delirium, Critical Illness
Interventions
Repositioning
Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 16, 2015 · Synced Jul 22, 2026, 11:57 AM EDT
Completed No phase listed Observational Results available

Validity and Feasibility of the CRSR-FAST

NCT03549572
View directory record Official record
Conditions
Disorder of Consciousness, Traumatic Brain Injury
Interventions
Coma Recovery Scale-Revised
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jul 22, 2026, 11:57 AM EDT
Recruiting Not applicable Interventional

PICU-related Sleep and Circadian Dysregulation Pilot Study

NCT06505447
View directory record Official record
Conditions
Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
Interventions
Daytime light exposure, Daytime restricted feeding
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
3 Years to 6 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Jul 22, 2026, 11:57 AM EDT
Not listed No phase listed Observational

Predictors of Respiratory Failure Following Extubation in the SICU

NCT01967056
View directory record Official record
Conditions
Muscle Weakness, Renal Failure, Respiratory Comorbidities
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2013 · Synced Jul 22, 2026, 11:57 AM EDT
Not listed Phase 4 Interventional

Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit

NCT04156464
View directory record Official record
Conditions
Alcohol Withdrawal, Alcohol Withdrawal Delirium
Interventions
Phenobarbital, Lorazepam
Drug
Lead sponsor
OSF Healthcare System
Other
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Jul 22, 2026, 11:57 AM EDT
Not listed Not applicable Interventional

Systematic Team Approach to Guide Early Mobilization in Surgical Intensive Care Unit Patients

NCT01363102
View directory record Official record
Conditions
Muscle Weakness, Critical Illness, Respiratory Insufficiency
Interventions
SOMS
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
3
States / cities
Boston, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Jul 22, 2026, 11:57 AM EDT