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ClinicalTrials.gov public records Last synced Oct 29, 2026, 4:26 AM EDT

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Showing 1–24 of 51 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Intensive Care Unit Delirium Clear all
Withdrawn No phase listed Observational

Brief Delirium Assessments in Non-Intensive Care Unit (ICU) Patients

NCT01162369
View directory record Official record
Conditions
Delirium
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
65 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Oct 29, 2026, 4:26 AM EDT
Recruiting Not applicable Interventional

Simultaneous Recumbent Cycling and Cognitive Training

NCT04556227
View directory record Official record
Conditions
Delirium, Impaired Cognition
Interventions
Simultaneous Cycle/Cognitive Training
Behavioral
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
45 Years to 64 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 29, 2026, 4:26 AM EDT
Completed No phase listed Observational

Helping Older Persons Emerge Stronger

NCT02863081
View directory record Official record
Conditions
Delirium, Ventilators, Pain, Agitation, Anxiety
Interventions
Survey, interview
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 19, 2017 · Synced Oct 29, 2026, 4:26 AM EDT
Terminated Phase 4 Interventional Results available

Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU

NCT02903407
View directory record Official record
Conditions
Deep Sedation, Ventilators, Mechanical, Critical Illness
Interventions
Midazolam, Propofol, Dexmedetomidine
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Oct 29, 2026, 4:26 AM EDT
Recruiting Not applicable Interventional

Neurosteer Bedside Monitoring System

NCT06718764
View directory record Official record
Conditions
Delirium, Sedation, Agitation
Interventions
Neurosteer's single-channel EEG monitoring device
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Recruiting No phase listed Observational

Digital and Plasma Biomarkers in Delirium

NCT07694206
View directory record Official record
Conditions
Critical Illness, Delirium in the Intensive Care Unit, Sleep Quality
Interventions
Not listed
Lead sponsor
Scripps Health
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Reducing Delirium in the Surgical Intensive Care Unit

NCT02856737
View directory record Official record
Conditions
Delirium
Interventions
eye masks and earplugs
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Oct 29, 2026, 4:26 AM EDT
Not yet recruiting Phase 3 Interventional

Phenobarbital for Agitated Delirium

NCT07548489
View directory record Official record
Conditions
Agitated Delirium, Delirium Confusional State, Delirium in the Intensive Care Unit, Hyperactive Delirium
Interventions
Phenobarbital, Conventional therapy group
Drug
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Terminated Not applicable Interventional Results available

Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones

NCT01343095
View directory record Official record
Conditions
Delirium, Sleep Fragmentation
Interventions
Foam Earplugs, Noise Canceling Headphones
Device
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Oct 29, 2026, 4:26 AM EDT
Completed No phase listed Observational

Ketamine Infusion as Sedative Analgesic in Severe ARDS

NCT04818827
View directory record Official record
Conditions
Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
Interventions
Not listed
Lead sponsor
Interfaith Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 26, 2021 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Not applicable Interventional Results available

Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

NCT04989790
View directory record Official record
Conditions
Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
Interventions
PICU Up!
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
1,470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
11
States / cities
Madera, California • Orlando, Florida • Louisville, Kentucky + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Not applicable Interventional

A Multidisciplinary Delirium Prevention Strategy Involving Psychiatry in the ICU

NCT03550495
View directory record Official record
Conditions
Delirium
Interventions
psychiatry involvement
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Not applicable Interventional Results available

Family Automated Voice Reorientation Study

NCT03128671
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Health, Subjective, Sleep
Interventions
FAVoR Intervention
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
3
States / cities
Miami, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 3, 2021 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Not applicable Interventional Results available

Decreasing Delirium Through Music in Critically Ill Older Adults

NCT04182334
View directory record Official record
Conditions
Intensive Care Unit Delirium, Pain, Anxiety, Intensive Care Acquired Cognitive Impairment
Interventions
Slow Tempo Music, Attention Control
Other
Lead sponsor
Indiana University
Other
Eligibility
50 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
5
States / cities
Avon, Indiana • Indianapolis, Indiana • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Phase 2 Interventional

Investigation of Sleep in the Intensive Care Unit

NCT03355053
View directory record Official record
Conditions
Delirium, Sleep
Interventions
Dexmedetomidine, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
522 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Oct 29, 2026, 4:26 AM EDT
Recruiting Not applicable Interventional

Behavioral Economic & Staffing Strategies in the ICU

NCT06184945
View directory record Official record
Conditions
Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication, ICU Acquired Weakness, Pain
Interventions
Realtime audit and feedback, RN Implementation Facilitator
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
16,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
Iowa City, Iowa • Omaha, Nebraska • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Phase 2 Interventional Results available

Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium

NCT00351299
View directory record Official record
Conditions
Delirium, Agitation
Interventions
Dexmedetomidine, Standard of Care
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Not applicable Interventional Results available

Acupuncture for Sedation in the Intensive Care Unit (ICU)

NCT01362270
View directory record Official record
Conditions
Delirium, Respiratory Depression, Overmedication
Interventions
Verum Acupuncture, Sham Acupuncture
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 20, 2020 · Synced Oct 29, 2026, 4:26 AM EDT
Active, not recruiting No phase listed Observational

The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors

NCT00392795
View directory record Official record
Conditions
Delirium, Cognition Disorders, Dementia
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
826 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2026
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Recruiting Not applicable Interventional

Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (VR-Cog)

NCT07496255
View directory record Official record
Conditions
Intensive Care Unit Delirium, Intensive Care Acquired Cognitive Impairment, Post Intensive Care Unit Syndrome, Virtual Reality Cognitive Training
Interventions
VR-based cognitive training program, VR-based attention control
Device
Lead sponsor
Indiana University
Other
Eligibility
50 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients

NCT07649876
View directory record Official record
Conditions
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
Interventions
Virtual reality (VR) therapy
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Completed No phase listed Observational

Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use

NCT04263662
View directory record Official record
Conditions
Mechanical Ventilation, Sedation
Interventions
Analgesia-Sedation algorithm
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 25 Years
Enrollment
680 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Oct 29, 2026, 4:26 AM EDT
Active, not recruiting No phase listed Observational

Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction in ICU Survivors, 2nd Study

NCT04305600
View directory record Official record
Conditions
Critical Illness, Intensive Care Unit Delirium
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
567 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
2
States / cities
Chicago, Illinois • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 29, 2026, 4:26 AM EDT
Recruiting Not applicable Interventional

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

NCT06411561
View directory record Official record
Conditions
Critical Illness, Delirium, Cognitive Impairment, Cognitive Decline, Alzheimer's Disease, Dementia, Circadian Dysrhythmia, Sleep Disturbance
Interventions
SLEEP + COG, COG, SLEEP, AC
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 29, 2026, 4:26 AM EDT