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ClinicalTrials.gov public records Last synced Jun 26, 2026, 10:49 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Interscalene Block Clear all
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty

NCT03663283
View directory record Official record
Conditions
Arthropathy Shoulder
Interventions
Liposomal Bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Liposomal Bupivacaine Plus Bupivacaine Peripheral Nerve Blockade Versus Ropivacaine Plus Dexamethasone Peripheral Nerve Blockade for Arthroscopic Rotator Cuff Repair

NCT04737980
View directory record Official record
Conditions
Rotator Cuff Tears, Shoulder Pain
Interventions
Liposomal bupivacaine, Bupivacaine Hcl 0.5% Inj, Ropivacaine 0.5% Injectable Solution, Dexamethasone
Drug
Lead sponsor
Hospital for Special Surgery Florida
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 7, 2021 · Synced Jun 26, 2026, 10:49 AM EDT
Terminated Not applicable Interventional

The Effect of Systemic or Perineural Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine

NCT01495624
View directory record Official record
Conditions
Duration of Interscalene Block
Interventions
ropivacaine plus dexamethasone anesthetic, ropivacaine plus saline plus dexamethasone anesthetic
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 26, 2016 · Synced Jun 26, 2026, 10:49 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Methadone and Interscalene Block for Shoulder Surgery

NCT03084588
View directory record Official record
Conditions
Pain
Interventions
methadone, Interscalene block
Drug · Procedure
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 24, 2020 · Synced Jun 26, 2026, 10:49 AM EDT
Terminated Phase 4 Interventional

Pain Management After Total Shoulder Arthroplasty

NCT03219983
View directory record Official record
Conditions
Glenohumeral Arthritis, Total Shoulder Arthroplasty
Interventions
Ropivacaine, liposomal bupivacaine
Drug
Lead sponsor
The Christ Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Interscalene Block With and Without Liposomal Bupivacaine in Shoulder Surgery

NCT03728946
View directory record Official record
Conditions
Rotator Cuff Tear, Postoperative Pain
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Orthopaedic & Neurosurgery Specialists
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
6
States / cities
Greenwich, Connecticut • Stamford, Connecticut • Atlantis, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Effective Pain Management of Interscalene Blocks During Shoulder Surgery

NCT02267044
View directory record Official record
Conditions
Primary Osteoarthritis, Unspecified Shoulder
Interventions
Ropivacaine
Drug
Lead sponsor
TriHealth Inc.
Other
Eligibility
Not listed
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 25, 2018 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Results available

Efficacy of Continuous Infusion Ropivacaine Interscalene Blocks

NCT02462382
View directory record Official record
Conditions
Full-thickness Rotator Cuff Tear
Interventions
Arthroscopic Rotator Cuff Repair, Ropivacaine, Saline
Procedure · Drug
Lead sponsor
Orlando Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Dec 21, 2020 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty

NCT04415931
View directory record Official record
Conditions
Shoulder Osteoarthritis, Cuff Tear Arthropathy, Massive Rotator Cuff Tear
Interventions
Local infiltration analgesia, Interscalene block
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 13, 2023 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Prospective RCT Comparing Perioperative Pain

NCT03253198
View directory record Official record
Conditions
Arthroplasty Shoulder
Interventions
Saline, Bupivacaine liposome
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Jun 26, 2026, 10:49 AM EDT
Not yet recruiting Phase 4 Interventional

Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study

NCT07146685
View directory record Official record
Conditions
Rebound Pain, Shoulder Arthroplasty, Interscalene Block
Interventions
Bupivacaine
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week

NCT01881776
View directory record Official record
Conditions
Postoperative Pain, Adverse Effects
Interventions
ISB
Procedure
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 75 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Diaphragm Movement After an Interscalene Block

NCT03636542
View directory record Official record
Conditions
Phrenic Nerve Paralysis
Interventions
liposomal bupivacaine, bupivacaine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 29, 2022 · Synced Jun 26, 2026, 10:49 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Superficial Cervical Plexus Blockade for Clavicle Fracture Analgesia

NCT03187899
View directory record Official record
Conditions
Pain, Postoperative, Satisfaction
Interventions
Ropivacaine, Normal saline
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 24, 2018 · Synced Jun 26, 2026, 10:49 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Total Intravenous Anesthesia With Propofol vs. General Anesthesia in Outpatient Shoulder Arthroscopic Surgeries

NCT04793022
View directory record Official record
Conditions
Rotator Cuff Tears, Rotator Cuff Injuries, Orthopedic Disorder, Sports Injury, Anesthesia
Interventions
TIVA with Propofol, Inhaled Anesthesia
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Jun 26, 2026, 10:49 AM EDT
Completed No phase listed Observational

Effects of Interscalene Brachial Plexus Nerve Blocks on the Hand and Forearm

NCT01229683
View directory record Official record
Conditions
Shoulder Surgery, Interscalene Nerve Block
Interventions
Interscalene Nerve Block
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2012 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty

NCT05005260
View directory record Official record
Conditions
Pain, Postoperative, Brachial Plexus Block
Interventions
Bupivacaine HCl, Liposomal bupivacaine + Bupivacaine Hcl 0.5% Inj
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Not applicable Interventional

Translational Manipulation Under Interscalene Block for Adhesive Capsulitis of the Shoulder (TMACS)

NCT03090555
View directory record Official record
Conditions
Shoulder Adhesive Capsulitis, Frozen Shoulder, Adhesive Capsulitis of Shoulder
Interventions
Translational manipulation, Manual therapy
Procedure
Lead sponsor
Daniel G. Rendeiro
Federal
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Phase 4 Interventional

Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks

NCT05482113
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Liposomal bupivacaine, Bupivacaine Hcl 0.25% Inj
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2022 · Synced Jun 26, 2026, 10:49 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block

NCT04642612
View directory record Official record
Conditions
Regional Anesthesia, Horner Syndrome, Cerebral Blood Flow
Interventions
TCD Measurement
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Liposomal Bupivacaine in Total Shoulder Arthroplasty

NCT02570022
View directory record Official record
Conditions
Pain
Interventions
Liposomal bupivacaine, Inter-scalene nerve block, Ropivacaine
Drug · Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 12, 2016 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery

NCT03822182
View directory record Official record
Conditions
Rotator Cuff Tear, Pain, Postoperative
Interventions
liposomal bupivicaine, Dexamethasone
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Avon, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Jun 26, 2026, 10:49 AM EDT
Completed Not applicable Interventional Results available

A Study Comparing Two Methods of Placing an Interscalene Nerve Catheter for Postoperative Pain Control in Patients Who Undergo Open Shoulder Surgery.

NCT01696188
View directory record Official record
Conditions
Shoulder Pain
Interventions
interscalene nerve catheter
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 15, 2015 · Synced Jun 26, 2026, 10:49 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Effect of Interscalene Block on Obstructive Sleep Apnea in Shoulder Surgery Patients

NCT02034370
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Lung-function spirometry test, Overnight sleep test
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 29, 2016 · Synced Jun 26, 2026, 10:49 AM EDT