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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:09 PM EDT

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Showing 1–24 of 214 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Intraocular Pressure Clear all
Completed Not applicable Interventional Results available

iCare vs Tonopen vs Goldmann Applanation Post-vitrectomy Surgery

NCT01786954
View directory record Official record
Conditions
Intraocular Pressure
Interventions
Icare rebound tonometry, Tonopen applanation, Goldmann applanation
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 23, 2016 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Not applicable Interventional Results available

Safety & Effectiveness Study of the Hydrus Microstent for Lowering IOP in Glaucoma Patients Undergoing Cataract Surgery (HORIZON)

NCT01539239
View directory record Official record
Conditions
Primary Open Angle Glaucoma
Interventions
Hydrus Aqueous Implant, Cataract surgery
Device · Procedure
Lead sponsor
Ivantis, Inc.
Industry
Eligibility
45 Years and older
Enrollment
1,143 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
26
States / cities
Phoenix, Arizona • Tucson, Arizona • Fayetteville, Arkansas + 23 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2021 · Synced Oct 20, 2026, 4:09 PM EDT
Completed No phase listed Observational

Collection of Blood Specimens From Patients in AL-3789 Studies for Elevated Intraocular Pressure (IOP)

NCT00691639
View directory record Official record
Conditions
Open-Angle Glaucoma
Interventions
Blood Collection Only
Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2009 · Synced Oct 20, 2026, 4:09 PM EDT
Completed No phase listed Interventional Accepts healthy volunteers Results available

Comparative Study of the NIDEK TONOREF III and the Haag-Streit Goldmann Manual Tonometer and Comparison of Pachymetry Values for NIDEK TONOREF III With the NIDEK CEM-530

NCT03441477
View directory record Official record
Conditions
Intraocular Pressure
Interventions
Nidek Tonoref III, Haag-Streit Goldmann Manual Tonometer, NIDEK CEM-530
Device
Lead sponsor
Nidek Co. LTD.
Industry
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 20, 2026, 4:09 PM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Eplerenone and IOP in Healthy Adults

NCT07795762
View directory record Official record
Conditions
Intraocular Pressure (IOP), Healthy Adult
Interventions
Eplerenone, Microcrystalline Cellulose NF (placebo)
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 20, 2026, 4:09 PM EDT
Withdrawn No phase listed Observational

The Effect of Omega-3 Fatty Acid Supplementation on Intraocular Pressure & Ocular Surface

NCT02295358
View directory record Official record
Conditions
Open Angle Glaucoma, Ocular Hypertension
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Oct 20, 2026, 4:09 PM EDT
Recruiting No phase listed Observational

A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients

NCT07076303
View directory record Official record
Conditions
Primary Open Angle Glaucoma, Glaucoma, Primary Open Angle Glaucoma or Ocular Hypertension
Interventions
Direct Selective Laser Trabuloplasty
Device
Lead sponsor
Brian Shafer
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2026
U.S. locations
1
States / cities
Plymouth Meeting, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Oct 20, 2026, 4:09 PM EDT
Completed No phase listed Observational

Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens

NCT00001161
View directory record Official record
Conditions
Aniridia, Eye Abnormality, Ocular Hypertension, Open Angle Glaucoma
Interventions
Not listed
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1977 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 20, 2026, 4:09 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Intraocular Pressure (IOP) Changes Associated With Muslim Prayer Postural Changes

NCT00454025
View directory record Official record
Conditions
Glaucoma
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 30, 2013 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Phase 3 Interventional Results available

Study of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

NCT02246764
View directory record Official record
Conditions
Ocular Hypertension, Glaucoma
Interventions
AR-13324 Ophthalmic Solution 0.02%, AR-13324 Ophthalmic Solution 0.02% BID, Timolol maleate Ophthalmic Solution 0.5% BID, Placebo
Drug · Other
Lead sponsor
Aerie Pharmaceuticals
Industry
Eligibility
19 Years to 99 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Bedminster, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 6, 2018 · Synced Oct 20, 2026, 4:09 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Intra-observer and Inter-observer Variability With Dynamic Contour Tonometry.

NCT00818233
View directory record Official record
Conditions
Intraocular Pressure
Interventions
Dynamic contour tonometry
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 20, 2026, 4:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy

NCT04046523
View directory record Official record
Conditions
Intracranial Pressure Increase
Interventions
Video ophthalmoscope
Device
Lead sponsor
University of Minnesota
Other
Eligibility
4 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 20, 2026, 4:09 PM EDT
Recruiting No phase listed Observational

IOP Reduction in Pigmentary Glaucoma Using DSLT

NCT07281391
View directory record Official record
Conditions
Pigmentary Dispersion Syndrome, Pigmentary Dispersion Glaucoma
Interventions
Voyager DSLT
Device
Lead sponsor
Mann Eye Institute
Other
Eligibility
Not listed
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 20, 2026, 4:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices

NCT05523622
View directory record Official record
Conditions
Glaucoma
Interventions
Tono-Vera tonometer, Goldman Applanation Tonometry
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 20, 2026, 4:09 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

External Influences Upon Ocular Homeostasis

NCT00338065
View directory record Official record
Conditions
Intraocular Pressure
Interventions
Postural change, Water drinking
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
10 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Phase 2 Interventional Results available

Ph2 Placebo-Controlled Study for Safety & Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Pts w/ Elevated Eye Pressure

NCT06144918
View directory record Official record
Conditions
Primary Open Angle Glaucoma, Ocular Hypertension
Interventions
SBI-100 Ophthalmic Emulsion, 0.5%, SBI-100 Ophthalmic Emulsion, 1.0%, SBI-100 Ophthalmic Emulsion, Placebo
Drug
Lead sponsor
Skye Bioscience, Inc.
Industry
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
3
States / cities
Glendale, California • Newport Beach, California • Cranberry Township, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 20, 2026, 4:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic

NCT01254149
View directory record Official record
Conditions
Normal Tension Glaucoma
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 1, 2023 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Not applicable Interventional

iCare HOME2 Clinical Trial

NCT05162989
View directory record Official record
Conditions
Intraocular Pressure, Glaucoma
Interventions
iCare HOME2 vs iCare IC200
Device
Lead sponsor
Icare Finland Oy
Industry
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Not applicable Interventional Results available

The Effects of the Water Drinking Test on Intraocular Pressure

NCT01507584
View directory record Official record
Conditions
Glaucoma
Interventions
SENSIMED Triggerfish
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Foot Reflexology in Ocular Hypertensive and Glaucoma Patients

NCT04695314
View directory record Official record
Conditions
Ocular Hypertension, Glaucoma
Interventions
Massage, Experimental insert, Sham insert
Device · Procedure
Lead sponsor
Temple University
Other
Eligibility
30 Years to 90 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2021 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Phase 2 Interventional

A Study to Determine the Safety and Tolerability of 2 Concentrations of QLS-101

NCT04947124
View directory record Official record
Conditions
Sturge-Weber Syndrome (SWS), Glaucoma, Glaucoma Congenital, Ocular Hypertension
Interventions
QLS-101ophthalmic solution 1%, QLS-101ophthalmic solution 2%
Drug
Lead sponsor
Qlaris Bio, Inc.
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2025 · Synced Oct 20, 2026, 4:09 PM EDT
Not listed Phase 4 Interventional

Intraocular Pressure Reduction Efficacy of Rhopressa and Lumigan in Normal Tension Glaucoma

NCT04981886
View directory record Official record
Conditions
Normal Tension Glaucoma
Interventions
Netarsudil Ophthalmic, Bimatoprost Ophthalmic
Drug
Lead sponsor
Salus University
Other
Eligibility
21 Years to 89 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Vestal, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Glaucoma Biomarkers

NCT01677507
View directory record Official record
Conditions
Glaucoma, Healthy
Interventions
Variation in eye pressure response to timolol and latanoprost treatment
Drug
Lead sponsor
University of Michigan
Other
Eligibility
40 Years and older
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
3
States / cities
Ann Arbor, Michigan • Rochester, Minnesota • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 13, 2017 · Synced Oct 20, 2026, 4:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Quick Measure Study for iCare ST500 and iCare IC200

NCT07156630
View directory record Official record
Conditions
Intraocular Pressure
Interventions
iCare ST500, iCare IC200, GAT, Tonovera
Device
Lead sponsor
Icare Finland Oy
Industry
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 20, 2026, 4:09 PM EDT