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Showing 1–24 of 72 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Intrauterine Contraception Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Intrauterine Lidocaine and Naproxen for Pain Control With Intrauterine Device Insertion

NCT02769247
View directory record Official record
Conditions
Contraception, Pain
Interventions
Naproxen, Lidocaine, placebo
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Controlled Trial of Oral Naproxen and Transdermal Estradiol for Bleeding in LNG-IUC

NCT00789802
View directory record Official record
Conditions
Contraception, Bleeding
Interventions
transdermal estradiol, naproxen, oral placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Phase 4 Interventional Results available

Women With Epilepsy: a Pilot Study of PK and PD Anti-epileptic Drug Effects in Levonorgestrel Intrauterine System Users

NCT02362373
View directory record Official record
Conditions
Epilepsy, Contraception
Interventions
levonorgestrel IUS
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 17, 2016 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacodynamics and Pharmacokinetics Study of Existing DMPA Contraceptive Methods

NCT02456584
View directory record Official record
Conditions
Contraception
Interventions
DMPA 150, DMPA 300, DMPA 104
Drug
Lead sponsor
FHI 360
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Jul 21, 2026, 8:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Postplacental Intrauterine Device Insertion: A Mixed Methods Assessment of Women's Experience

NCT02312726
View directory record Official record
Conditions
Contraception
Interventions
Postplacental IUD insertion
Procedure
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 3, 2016 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Naproxen for Pain Control With Intrauterine Device Insertion

NCT02388191
View directory record Official record
Conditions
Contraception
Interventions
Naproxen sodium, Placebo tablet
Drug · Other
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Early vs. Interval Postpartum IUD Insertion

NCT03462758
View directory record Official record
Conditions
Contraception
Interventions
IUD
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
404 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
4
States / cities
La Jolla, California • San Diego, California • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Jul 21, 2026, 8:20 PM EDT
Withdrawn Phase 2Phase 3 Interventional Accepts healthy volunteers

Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women

NCT04089852
View directory record Official record
Conditions
Contraceptive Devices, Long-Acting Reversible Contraception, Analgesia, Adolescent Health, Gynecology
Interventions
Nitrous oxide gas for inhalation, Oxygen Gas for Inhalation
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
14 Years to 24 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Jul 21, 2026, 8:20 PM EDT
Terminated Not applicable Interventional

Intrauterine Device (IUD) Self Removal

NCT05191238
View directory record Official record
Conditions
IUD Removal
Interventions
IUD self-removal education
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 21, 2023 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Reduction During Intrauterine Device (IUD) Insertion in Outpatient Gynecology

NCT06335823
View directory record Official record
Conditions
IUD Insertion Pain
Interventions
Transcutaneous electrical nerve stimulation (TENS), Placebo Transcutaneous electrical nerve stimulation (TENS)
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jul 21, 2026, 8:20 PM EDT
Withdrawn Not applicable Interventional

Levonorgestrel-Intrauterine System (LNG-IUS) Insertion in the Postpartum Period

NCT01088178
View directory record Official record
Conditions
Contraception
Interventions
Levonorgestrel Intrauterine System (LNG-IUS: Mirena, Bayer)
Device
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
16 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 21, 2026, 8:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Study on Medical Records of Women Using an Intrauterine Device (IUD) to Analyze the Risks That the IUD Will be Expelled or Perforates the Womb in Relation to Breastfeeding, the Point in Time When the IUD Was Inserted After Childbirth and in Relation to Different Types of IUDs

NCT03754556
View directory record Official record
Conditions
Intrauterine Devices
Interventions
Intrauterine device
Device
Lead sponsor
Bayer
Industry
Eligibility
Up to 50 Years · Female only
Enrollment
326,658 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
4
States / cities
Oakland, California • Pasadena, California • Indianapolis, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional

Cluster, Randomized Trial on Long Acting Reversible Contraception (LARC) Education and Training

NCT01360216
View directory record Official record
Conditions
Contraception Behavior
Interventions
LARC education and training
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot #2 of Social Network Intrauterine Contraceptive (IUC) Intervention

NCT02242890
View directory record Official record
Conditions
Attitudes
Interventions
Contraception Information Packet
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
15 Years to 45 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
North Highlands, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2015 · Synced Jul 21, 2026, 8:20 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

A Multicenter Analysis of Levonorgestrel-Intrauterine System (LNG-IUS) Use in the Postpartum Period

NCT01161095
View directory record Official record
Conditions
Contraception, Postpartum Period
Interventions
LNG-IUS
Device
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
2
States / cities
Little Rock, Arkansas • Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 21, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Patient-centered Information on Permanent Contraception

NCT06296797
View directory record Official record
Conditions
Contraception, Reproductive Behavior, Contraception Behavior
Interventions
Control arm: Existing educational website, Advancing Access Website
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
650 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Nitroglycerin on the Intrauterine Device (IUD) Insertion Experience in Nulliparous Women

NCT01490073
View directory record Official record
Conditions
Contraception, Pain
Interventions
Insertion of nitroglycerin ointment, Insertion of placebo ointment
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Maintaining Intrauterine Devices (IUDs) in Teens (MINT): A Randomization Trial

NCT00653159
View directory record Official record
Conditions
Contraception
Interventions
Levonorgestrel-releasing intrauterine device (LNG-IUS), Copper T380A intrauterine device (CuT380A)
Device
Lead sponsor
University of Chicago
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Not applicable Interventional Results available

Immediate Postplacental Insertion of IUDs at Time of Cesarean Delivery: A Randomized Clinical Trial

NCT01539759
View directory record Official record
Conditions
Intrauterine Devices, Cesarean Section
Interventions
Immediate Postplacental Placement of an IUD during cesarean delivery
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Jul 21, 2026, 8:20 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

A Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible Contraception

NCT00995150
View directory record Official record
Conditions
Contraception
Interventions
LNG20, Mirena
Drug
Lead sponsor
Medicines360
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
1,910 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2021
U.S. locations
25
States / cities
Phoenix, Arizona • Palo Alto, California • San Francisco, California + 22 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Jul 21, 2026, 8:20 PM EDT
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

Evaluation of the Efficacy, Safety, and Tolerability of LevoCept

NCT04457076
View directory record Official record
Conditions
Contraception, Women at Risk for Pregnancy
Interventions
LevoCept
Drug
Lead sponsor
Sebela Women's Health Inc.
Industry
Eligibility
Up to 45 Years · Female only
Enrollment
1,525 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2032
U.S. locations
27
States / cities
Berkeley, California • Los Angeles, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Phase 4 Interventional Results available

A Pilot Study of Early Postpartum Intrauterine Contraception

NCT00997932
View directory record Official record
Conditions
Unplanned Pregnancy
Interventions
Levonorgestrel-Releasing Intrauterine Contraceptive System (LNG-IUS), 52 Mg, 5 Year Duration
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Jul 21, 2026, 8:20 PM EDT
Completed No phase listed Observational Results available

Patient Factors Associated With Fragmentation of Copper Intrauterine Device (IUD) Requiring Hysteroscopic Removal

NCT07351084
View directory record Official record
Conditions
Intrauterine Device Complications, Contraceptive Device Failure, IUD Fragmentation, Retained Intrauterine Device, Female Contraception, Women's Health, Reproductive Health
Interventions
Not listed
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
44 participants
Timeline
2025
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 21, 2026, 8:20 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of ContraMed VeraCept Intrauterine Copper Contraceptive for Long Acting Reversible Contraception

NCT02446821
View directory record Official record
Conditions
Contraception
Interventions
VeraCept
Drug
Lead sponsor
Sebela Women's Health Inc.
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
286 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
12
States / cities
Burbank, California • Los Angeles, California • Sacramento, California + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 21, 2026, 8:20 PM EDT